Geographic note on species of the genus Upa Kimsey, 1991 (Hymenoptera: Tiphiidae, Thynninae) in the Atlantic Forest, Brazil

Upa Kimsey is a poorly known genus of Tiphiidae with seven species. This genus has records in forest areas and in this paper we present new records to four species. All specimens were collected by malaise traps in four areas of Atlantic Rain Forest and three of Atlantic Semi-deciduous forest, mainly from high and mid-elevations. The new records indicate that species of Upa are not as rare as others genera of Tiphiidae, which are virtually unknown in many Neotropical regions.

Evaluación de variables lineales y de crecimiento en becerros y becerras de la raza brahman y sus cruces en la finca San Miguel, Barranca de Upía, Meta

Tesis (Zootecnista). -- Universidad de La Salle. Facultad de Ciencias Agropecuarias. Programa de Zootecnia, 2014

Plano de intervenção: educação preventiva para a qualidade de vida de pacientes com hipertensão arterial sistêmica na UPA Homero Gil, em Betim - Minas Gerais

As doenças crônicas não transmissíveis são hoje responsáveis pela maioria das doenças e mortes em muitos países, entre elas, a hipertensão arterial sistêmica. Os desafios do controle e prevenção da hipertensão arterial sistêmica e suas complicações fazem parte da rotina das equipes de atenção básica, buscando assim, um vínculo entre a comunidade e a clientela registrada, observando-se a diversidade cultural, racial, religiosa e diversos fatores sociais envolvidos. Desta maneira, o projeto de intervenção tem como finalidade orientar os portadores de hipertensão arterial sistêmica sobre as modificações no cotidiano de vida, principalmente, no processo terapêutico e preventivo, destacando aspectos, como a alimentação adequada, sobretudo quanto ao consumo de sal e o controle do peso. A prática de atividades físicas, abandono do tabagismo, diminuição do uso de álcool, pois estes são fatores que necessitam ser abordados e controlados para que os níveis desejados da pressão arterial sejam atingidos. Assim, a criação de projetos que visem sanar esse problema é de suma importância para promover a qualidade de vida do portador de Hipertensão Arterial Sistêmica.

In Vitro Identification of Novel Plasminogen-Binding Receptors of the Pathogen Leptospira interrogans

Background: Leptospirosis is a multisystem disease caused by pathogenic strains of the genus Leptospira. We have reported that Leptospira are able to bind plasminogen (PLG), to generate active plasmin in the presence of activator, and to degrade purified extracellular matrix fibronectin. Methodology/Principal Findings: We have now cloned, expressed and purified 14 leptospiral recombinant proteins. The proteins were confirmed to be surface exposed by immunofluorescence microscopy and were evaluated for their ability to bind plasminogen (PLG). We identified eight as PLG-binding proteins, including the major outer membrane protein LipL32, the previously published rLIC12730, rLIC10494, Lp29, Lp49, LipL40 and MPL36, and one novel leptospiral protein, rLIC12238. Bound PLG could be converted to plasmin by the addition of urokinase-type PLG activator (uPA), showing specific proteolytic activity, as assessed by its reaction with the chromogenic plasmin substrate, D-Val-Leu-Lys 4-nitroanilide dihydrochloride. The addition of the lysine analog 6-aminocaproic acid (ACA) inhibited the protein-PLG interaction, thus strongly suggesting the involvement of lysine residues in plasminogen binding. The binding of leptospiral surface proteins to PLG was specific, dose-dependent and saturable. PLG and collagen type IV competed with LipL32 protein for the same binding site, whereas separate binding sites were observed for plasma fibronectin. Conclusions/Significance: PLG-binding/activation through the proteins/receptors on the surface of Leptospira could help the bacteria to specifically overcome tissue barriers, facilitating its spread throughout the host.