On the Beautiful and the Ugly

Classical aesthetics sees the experience of the beautiful as an anthropological necessity. But, in fact, the beautiful is rather the central category designating classical art, and one can question the relevance of this category considering contemporary art. The reference term most frequently used for contemporary art is interesting: works of art solicit the interests of my faculties (the cognitive-intellectual, the pragmatic community-oriented moral, the affective aesthetic faculties). It is interesting to notice that the categories of the beautiful and the ugly have an axiological-moral value. It looks as if the qualities of contemporary art works are judged according to the intensity of the impact on the interests of our faculties. It reveals important, in this respect, to distinguish the ugly from the sublime and the monstrous. Kant’s Third Critique is of some importance in defining these categories.

Gender equality, poverty and achievement of the Millennium Development Goals (MDGs) in the Caribbean subregion

The Millennium Development Goals (MDGs) are fundamentally a set of eight global goals for the achievement of basic economic and social rights for all, with time-bound targets to be achieved by the year 2015. In adopting the Millennium Declaration in 2000, the member States of the United Nations pledged to “spare no effort to free our fellow men, women and children from the abject and dehumanizing conditions of extreme poverty.”1 The focus of this report is on the progress made by Caribbean countries towards the achievement of Goal 1: the eradication of extreme poverty and hunger; and Goal 3: the promotion of gender equality and the empowerment of women, and identifies linkages between the two goals.

L’abjection dans les récits de Nelly Arcan

Comment comprendre l’abjection qui travaille les textes littéraires de femmes auteures contemporaines ? Quelle abjection habite les récits Putain (2001), Folle (2004) et À ciel ouvert (2007) de la Québécoise Nelly Arcan? D’abord, sont esquissées une synthèse des multiples acceptions théoriques de l’abjection et une liste d’« objets » à l’abjection archétypale, avant de montrer comment l’abject est susceptible d’être dialectiquement relevé en son contraire, notamment dans l’œuvre littéraire. Une carte de l’imaginaire de l’abjection arcanienne est ensuite dressée : les représentations abjectes du féminin donnent naissance à plusieurs topos spécifiques, et des mécanismes abjects dé-forment le corps du texte, entraîné dans la logique tragique de l’éternel retour. Puis les effets performatifs du texte arcanien sont examinés : sur le plan affectif, il permettent une purification de l’abjection et, sur le plan discursif et énonciatif, une critique de celle-ci. Enfin, le corpus arcanien, à la fois poétiquement, esthétiquement et performativement, s’inscrit dans le sillage des grands écrivains de l’abjection du XXe siècle. C’est, en tout cas, ce que les résultats de cette étude permettent de conclure.

Encountering Anthropomorphism (Editorial)

On Anthropomorphism concerns itself with performances and artworks that explore the complex of interesting and mutually contradictory ideas located under the umbrella term, ‘anthropomorphism’. On the one hand, it is used to refer to something that resembles a human, and on the other hand it refers to our natural tendency to read human characteristics in the non-human object or animal. Moreover, an interrogation of the concept of anthropomorphism, especially as it is found in contemporary performance, suggests that there is not a singular line dividing the human from the non-human but a vast terrain that houses the comical, the uncanny and the abject. The aim of this issue is to elucidate anthropomorphism in its multitude of aspects, thereby shedding light on discourses around object theatre and ecological performance that attempt to understand the more-than-human world in a way that goes beyond ‘mere’ anthropomorphism.

'Freakish Fat', 'Wretched Black': Female abject beings in contemporary Colombian media and culture

This paper explores the construction of female abject beings in Colombian contemporary media and culture comparing a character in the 2010 telenovela Chepe Fortuna named Venezuela, and the cultural representation of Piedad Córdoba. I argue that the construction of these two characters as abject beings is coherent with the dominant discourse of Alvaro Uribe's national project, which relied on a strong nationalist rhetoric based on binary oppositions of the type "we/other." In this context both Chepe Fortuna's Venezuela and Piedad Córdoba are constructed as "other." While Venezuela's abjection is partly effected on the basis of her being fat and black, Córdoba's is on the basis of her being a left-wing politician, and mediated through her being a black female. These two instances evidence an approach to femaleness that goes hand-in-hand with particular understandings of female subjectivity within current post-feminist paradigms.

Aleatory Sovereignty and the Rule of Sensitive Spaces

Addressing life in borders and refugee camps requires understanding the way these spaces are ruled, the kinds of problems rule poses for the people who live there, and the abilities of inhabitants to remake their own lives. Recent literature on such spaces has been influenced by Agamben's notion of sovereignty, which reduces these spaces and their residents to abstractions. We propose an alternate framework focused on what we call aleatory sovereignty, or rule by chance. This allows us to see camps and borders not only as the outcomes of humanitarian projects but also of anxieties about governance and rule; to see their inhabitants not only as abject recipients of aid, but also as individuals who make decisions and choices in complex conditions; and to show that while the outcome of projects within such spaces is often unpredictable, the assumptions that undergird such projects create regular cycles of implementation and failure.

Street-Ball: The Myth of the Ghetto Basketball Star

In recent decades, countless scholars have examined the developing trend of African American dominance in United States’ professional sports. Many have hypothesized that this over-representation is caused by the presumed reliance on sports as an avenue out of poverty for the African American youths. This trend, it is believed, has a highly detrimental effect the African American community. In actuality, this argument is flawed because it works under the stereotypical assumption that the overwhelming majority of African Americans come from abject poverty. To dispel this fallacy, the author has analyzed the upbringings of each All-National Basketball League First Team player over the past thirty years. The author discovered that while the majority of the players selected were African American, only a small percentage of these athletes were raised in a poverty-stricken environment. Logically, this would not be the case if poor African Americans relied more heavily on sports than middle-class African Americans. This data proves that stereotypes, not empirical evidence, are the substance of nearly every previous study conducted on the topic.

Public attitudes on the ethics of deceptively planting false memories to motivate healthy behavior

Researchers have proposed that planting false memories could have positive behavioral consequences. The idea of deceptively planting “beneficial” false memories outside of the laboratory raises important ethical questions, but how might the general public appraise this moral dilemma? In two studies, participants from the USA and UK read about a fictional “false-memory therapy” that led people to adopt healthy behaviors. Participants then reported their attitudes toward the acceptability of this therapy, via scale-rating (both studies) and open-text (Study 2) responses. The data revealed highly divergent responses to this contentious issue, ranging from abject horror to unqualified enthusiasm. Moreover, the responses shed light on conditions that participants believed would make the therapy less or more ethical. Whether or not deceptively planting memories outside the lab could ever be justifiable, these studies add valuable evidence to scientific and societal debates on neuroethics, whose relevance to memory science is increasingly acute.

Economic Development and Mass Poverty in Africa: Assessment of the Nigerian Experience

The forces surrounding the emerging economies of underdeveloped world, especially Africa has practically stifled its economic progress, growth, development and sustainability. This economic condition brings to the fore the massive onslaught of rural/urban poverty which the African continent grapples with since the post-world war II era to date. The economic misfortunes and incidence of mass poverty in Africa, vis-à-vis Nigeria is used as a point of departure in this study. The paper underscores the ideological and philosophical undertone of international capital manifesting in form of colonialism and imperialism as a major character in the historical process of underdevelopment and mass poverty in peripheral states of Africa, Asia and Latin America, respectively. Of particular interest in this study is the activities of domestic bourgeoisie elite class who have vigorously displayed some degree of lack of much needed vision and abject lack of desires to draw up workable plans to redeem the battered image of African/ Nigerian economic misfortunes. This state of affairs has practically engendered economic underdevelopment, misery and disturbing levels of poverty in the nation-state system. The paper concludes with the forward towards realizing the vision 20-20-20 objectives in the 21t century and beyond.

Devotional reading and dissolving the self: a critical reading of the late medieval Scottish Legendary using Kristevan theory

The Scottish Legendary is a fourteenth century collection of saints’ lives in Older Scots. The prologue describes the lives as ‘merroure’ (mirror) to readers from which ‘men ma ensample ta’ (people may take example). Thus, the Legendary sets out to reveal how the reader is (mirror) thereby moving her to wish to become how she should be (exemplarity). This dissertation argues that, rather than encouraging devotion to saints along purely dogmatic lines, the Legendary transforms the reader’s selfhood by engaging her affectively, i.e. on an emotional and somatic level. By provoking the reader affectively, the text puts the reader into what Julia Kristeva has described as a ‘semiotic state’ which harks back to the reader’s or listener’s pre-cultural, pre-subjective self (Kristeva, 1984). Thus, the text disrupts the reader’s conception of herself as a complete, hermetic subjectivity, thereby dissolving the boundaries of the reader’s self. The Legendary most powerfully infiltrates the reader’s sense of self along these lines in the moments in which female saints’ bodies are tortured and dismembered. These scenes foreground the permeability of human flesh as well as its powerful influence over selfhood. Such images of abjection are, in Kristeva’s words, ‘opposed to I’; by confronting the reader with the disintegration of subjectivity in abjection, the text incites the reader to likewise experience herself as abject, i.e. disintegrable and permeable (Kristeva 1982). As I shall demonstrate, Kristeva’s psychoanalytic theory of the formation of the self offers a fruitful framework for understanding the processes of self-knowledge through reading that these saints’ lives inspire.

The Legacy of Frankenstein’s Creature: Monstrosity and Female Grotesque in Mary Shelley, Angela Carter and Jeanette Winterson

This English Literature thesis (European PhD EDGES – Women’s and Gender Studies – 34th cycle) is an investigation into the representation of the monstrous body according to the British writers Mary Shelley, Angela Carter and Jeanette Winterson. The main objective is to observe how the representation of the categories of monstrous, abject and grotesque in Western cultural imagination have been influenced across time and literary genres. In the novels of Shelley, Carter and Winterson, the monstrous subject is configured as an alternative to the anthropocentric ideal embodied by the normative subject, of which Victor Frankenstein is the paradigmatic exponent. Plus, there are places considered anti-topoi within which the monster acquires a situatedness and claims a voice, generating an opposed counter-narrative to the imaginary conveyed by the normative subject. Monstrosity outlined by Shelley in the novels Frankenstein and The Last Man constitutes the starting point of my research, aiming to observe how the discourse of the normative body vs. the anti-normative body intersects with the discourse of the spaces of the centre vs. the spaces of the margin. In Carter's novels The Passion of New Eve and Nights at the Circus, the monstrous female constitutes the embodiment of wills, desires and claims challenging the heteronormative system. The space of otherness in which Carter's monster-woman is confined becomes a possibility of reshaping identity for the Subject, deconstructing the logic of power that moulded her within society. Finally, Winterson creates two monstrous women in Sexing the Cherry and The Passion who move through urban spaces, going from the centre to the margins and testifying to the arbitrariness of the system and its weaknesses. Similarly, in Frankissstein, Winterson recovers Shelley's original novel and transforms it into a parodic and intertextual speculation on the fluidity of identity and the limits of transhumanism.

Pipkiiα Is Widely Expressed In Hematopoietic-derived Cells And May Play A Role In The Expression Of Alpha- And Gamma-globins In K562 Cells.

Characterized for the first time in erythrocytes, phosphatidylinositol phosphate kinases (PIP kinases) belong to a family of enzymes that generate various lipid messengers and participate in several cellular processes, including gene expression regulation. Recently, the PIPKIIα gene was found to be differentially expressed in reticulocytes from two siblings with hemoglobin H disease, suggesting a possible relationship between PIPKIIα and the production of globins. Here, we investigated PIPKIIα gene and protein expression and protein localization in hematopoietic-derived cells during their differentiation, and the effects of PIPKIIα silencing on K562 cells. PIPKIIα silencing resulted in an increase in α and γ globins and a decrease in the proliferation of K562 cells without affecting cell cycle progression and apoptosis. In conclusion, using a cell line model, we showed that PIPKIIα is widely expressed in hematopoietic-derived cells, is localized in their cytoplasm and nucleus, and is upregulated during erythroid differentiation. We also showed that PIPKIIα silencing can induce α and γ globin expression and decrease cell proliferation in K562 cells.

The Clinical Impact Of Cerebellar Grey Matter Pathology In Multiple Sclerosis.

The cerebellum is an important site for cortical demyelination in multiple sclerosis, but the functional significance of this finding is not fully understood. To evaluate the clinical and cognitive impact of cerebellar grey-matter pathology in multiple sclerosis patients. Forty-two relapsing-remitting multiple sclerosis patients and 30 controls underwent clinical assessment including the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale (EDSS) and cerebellar functional system (FS) score, and cognitive evaluation, including the Paced Auditory Serial Addition Test (PASAT) and the Symbol-Digit Modalities Test (SDMT). Magnetic resonance imaging was performed with a 3T scanner and variables of interest were: brain white-matter and cortical lesion load, cerebellar intracortical and leukocortical lesion volumes, and brain cortical and cerebellar white-matter and grey-matter volumes. After multivariate analysis high burden of cerebellar intracortical lesions was the only predictor for the EDSS (p<0.001), cerebellar FS (p = 0.002), arm function (p = 0.049), and for leg function (p<0.001). Patients with high burden of cerebellar leukocortical lesions had lower PASAT scores (p = 0.013), while patients with greater volumes of cerebellar intracortical lesions had worse SDMT scores (p = 0.015). Cerebellar grey-matter pathology is widely present and contributes to clinical dysfunction in relapsing-remitting multiple sclerosis patients, independently of brain grey-matter damage.

Obesity And Inflammation And The Effect On The Hematopoietic System.

Bone marrow is organized in specialized microenvironments known as 'marrow niches'. These are important for the maintenance of stem cells and their hematopoietic progenitors whose homeostasis also depends on other cell types present in the tissue. Extrinsic factors, such as infection and inflammatory states, may affect this system by causing cytokine dysregulation (imbalance in cytokine production) and changes in cell proliferation and self-renewal rates, and may also induce changes in the metabolism and cell cycle. Known to relate to chronic inflammation, obesity is responsible for systemic changes that are best studied in the cardiovascular system. Little is known regarding the changes in the hematopoietic system induced by the inflammatory state carried by obesity or the cell and molecular mechanisms involved. The understanding of the biological behavior of hematopoietic stem cells under obesity-induced chronic inflammation could help elucidate the pathophysiological mechanisms involved in other inflammatory processes, such as neoplastic diseases and bone marrow failure syndromes.