Influência de uma fenda na dinâmica de vórtices utilizando a teoria de Ginzburg-Landau dependente do temp

Pós-graduação em Ciência dos Materiais - FEIS

Shakespearean extracts from "Edward Pudsey's booke", temp. Q. Elizabeth & K. James I. which include some from an unknown play by William Shakespeare [or rather from Chapman's "Blind beggar of Alexander"] Also a few unpublished records of the Shakespeare of Snitterfield and Wroxall preserved in the Public Record Office.

Mode of access: Internet.

Explanatory notes of a pack of Cavalier playing cards, temp. Charles II. : forming a complete political satire of the commonwealth /

Mode of access: Internet.

The history and life of the Reverend Doctor John Tauler of Strasbourg. With twenty-five of his sermons (temp. 1340)

Mode of access: Internet.

Verney papers. Notes of proceedings in the Long parliament, temp. Charles I. printed from the original pencil memoranda taken in the House of Sir Ralph Verney, knight, member for the borough of Aylesbury, and now in the possession of Sir Harry Verney, Bart.

Camden society reports, list of members, etc.: 35 p. at end.

The aldermen of the city of London temp. Henry III.-1908. With notes on the parliamentary representation of the city, the aldermen and the livery companies, the aldermanic veto, aldermanic baronets and knights, etc.,

Vol. II has title: The aldermen of the city of London temp. Henry III.-1912.

Fragm. lat. I 45 - Epistolarium (Fer.V p.Dom.I Quadr., Fer.VI et Sabb. VI temp. Quadr.)

Trägerband: 'Questiones magistri Johannis Versoris super Metaphisicam... De generacione et corruptione Arestotilis'; Vorbesitzer: Dominikanerkloster Frankfurt am Main

Fragm. lat. I 70 - Missale (Dom.Pent. - Sabb. IV temp.Pent.)

Trägerband: 'Misc.var. 294'; Vorbesitzer: Dominikanerkloster Frankfurt am Main

An integer programming framework for sequencing cutting patterns based on interval graph completion

We derived a framework in integer programming, based on the properties of a linear ordering of the vertices in interval graphs, that acts as an edge completion model for obtaining interval graphs. This model can be applied to problems of sequencing cutting patterns, namely the minimization of open stacks problem (MOSP). By making small modifications in the objective function and using only some of the inequalities, the MOSP model is applied to another pattern sequencing problem that aims to minimize, not only the number of stacks, but also the order spread (the minimization of the stack occupation problem), and the model is tested.

Stable transmission of targeted gene modification using single-stranded oligonucleotides with flanking LNAs.

Targeted mutagenesis directed by oligonucleotides (ONs) is a promising method for manipulating the genome in higher eukaryotes. In this study, we have compared gene editing by different ONs on two new target sequences, the eBFP and the rd1 mutant photoreceptor betaPDE cDNAs, which were integrated as single copy transgenes at the same genomic site in 293T cells. Interestingly, antisense ONs were superior to sense ONs for one target only, showing that target sequence can by itself impart strand-bias in gene editing. The most efficient ONs were short 25 nt ONs with flanking locked nucleic acids (LNAs), a chemistry that had only been tested for targeted nucleotide mutagenesis in yeast, and 25 nt ONs with phosphorothioate linkages. We showed that LNA-modified ONs mediate dose-dependent target modification and analyzed the importance of LNA position and content. Importantly, when using ONs with flanking LNAs, targeted gene modification was stably transmitted during cell division, which allowed reliable cloning of modified cells, a feature essential for further applications in functional genomics and gene therapy. Finally, we showed that ONs with flanking LNAs aimed at correcting the rd1 stop mutation could promote survival of photoreceptors in retinas of rd1 mutant mice, suggesting that they are also active in vivo.

Increased blood glucose variability during therapeutic hypothermia and neurological recovery after cardiac arrest

INTRODUCTION. Recent studies suggest that increased blood glucose variability (BGV) is associated with ICU mortality1. Hypothermia is known to induce insulin resistance, thus potentially increasing BGV. No studies however have examined the effect of therapeutic hypothermia (TH) on insulin requirements and BGV. OBJECTIVES. To examine the effect of TH on BGV and its relationship to outcome in patients with coma after cardiac arrest (CA). METHODS. We prospectively studied 132 consecutive comatose CA patients treated with TH (target core temp 33_C for 24 h, using surface cooling). All patients were treated with intravenous insulin (blood glucose target 6-8 mM), according to a written algorithm, with nurse-driven adjustment of insulin dose. For each patient, standard deviation of repeated blood glucose samples was used to calculate BGV. Two time-points, comparable in duration, were studied: TH (stable maintenance phase, i.e. 6-24 h, core temp ± 33_C) vs. Normothermia (NT, i.e. after rewarming, stable normothermic phase, core temp ± 37_C). Mortality and neurological recovery (Glasgow-Pittsburgh Cerebral Performance Categories, CPC, dichotomized as good = CPC 1-2 vs. poor = CPC 3-5) were assessed at hospital discharge. Statistical analysis was performed with ANOVA for repeated measures. RESULTS. Compared to NT, TH was associated with increased intravenous insulin dose (0.8 ± 1.1 vs. 1.6 ± 2 U/h, P\0.0001), higher mean (6.9 ± 1.3 vs. 7.7 ± 1.8 mM, P\0.0001) and maximum (9.1 ± 3.7 vs. 10.9 ± 3.6 mM, P\0.0001) blood glucose, and increased BGV (1.3 ± 1.2 vs. 1.7 ± 1.1 mM, P = 0.004). Increased BGV was strongly associated with mortality (2.5 ± 1.5 mM in non-survivors vs. 1.6 ± 1 mM in survivors, P\0.001) and worse outcome (2.3 ± 1.4 mM in patients with poor vs. 1.5 ± 0.8 mM in those with good neurological recovery, P\0.0001). CONCLUSIONS. Therapeutic hypothermia is associated with increased insulin requirements and higher blood glucose variability,which in turn correlateswithworse prognosis in patientswith post- CA coma. Strategies aimed to maintain stable glycemic profile and avoid blood glucose variability might contribute to optimize the management of TH and may translate into better outcome.

Na rota dos Judeus uma análise histórica e potencialidades para o desenvolvimento do Turismo em Santo Antão

Tendo como ponto de partida a antiga presença judaica na cidade de Ponta do Sol, e o relevante património histórica deixado, neste trabalho fizemos um levantamento histórico patrimonial como forma de mostrar o potencial turístico a nível de turismo cultural/religioso da cidade de Ponta do Sol, assim como da ilha de Santo Antão por onde os judeus deixaram marcas da presença ou passagem. Para a concretização deste estudo recorreu-se à revisão da literatura referente ao turismo cultural e religioso, nomeadamente ao turismo judaico, assim como patrimónios tangíveis e intangíveis. Fez-se entrevistas e utilizou-se o método de observação directa, de forma a colher subsídios que nos permitisse a elaboração do corpo do trabalho e citar algumas propostas e recomendações. Os dados colhidos permitiram a elaboração de algumas propostas como a revitalização dos edifícios, revitalização das ruas e dos cemitérios e a sinagoga, definindo no final propostas gerais. Por fim, propôs-se a criação de duas rotas (Culto e Morte, Ne kel temp de Judeu – No tempo dos Judeus) na cidade/ilha de forma que o visitante possa conhecer e desfrutar tanto a visita na cidade como toda a sua história.

Statistical analysis and modelling of weather radar beam propagation conditions in the Po Valley (Italy)

Ground clutter caused by anomalous propagation (anaprop) can affect seriously radar rain rate estimates, particularly in fully automatic radar processing systems, and, if not filtered, can produce frequent false alarms. A statistical study of anomalous propagation detected from two operational C-band radars in the northern Italian region of Emilia Romagna is discussed, paying particular attention to its diurnal and seasonal variability. The analysis shows a high incidence of anaprop in summer, mainly in the morning and evening, due to the humid and hot summer climate of the Po Valley, particularly in the coastal zone. Thereafter, a comparison between different techniques and datasets to retrieve the vertical profile of the refractive index gradient in the boundary layer is also presented. In particular, their capability to detect anomalous propagation conditions is compared. Furthermore, beam path trajectories are simulated using a multilayer ray-tracing model and the influence of the propagation conditions on the beam trajectory and shape is examined. High resolution radiosounding data are identified as the best available dataset to reproduce accurately the local propagation conditions, while lower resolution standard TEMP data suffers from interpolation degradation and Numerical Weather Prediction model data (Lokal Model) are able to retrieve a tendency to superrefraction but not to detect ducting conditions. Observing the ray tracing of the centre, lower and upper limits of the radar antenna 3-dB half-power main beam lobe it is concluded that ducting layers produce a change in the measured volume and in the power distribution that can lead to an additional error in the reflectivity estimate and, subsequently, in the estimated rainfall rate.