22 resultados para scribes


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The immune system plays an important role in defending the body against tumours and other threats. Currently, mechanisms involved in immune system interactions with tumour cells are not fully understood. Here we develop a mathematical tool that can be used in aiding to address this shortfall in understanding. This paper de- scribes a hybrid cellular automata model of the interaction between a growing tumour and cells of the innate and specific immune system including the effects of chemokines that builds on previous models of tumour-immune system interactions. In particular, the model is focused on the response of immune cells to tumour cells and how the dynamics of the tumour cells change due to the immune system of the host. We present results and predictions of in silico experiments including simulations of Kaplan-Meier survival-like curves.

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This paper discusses a model of the civil aviation reg- ulation framework and shows how the current assess- ment of reliability and risk for piloted aircraft has limited applicability for Unmanned Aircraft Systems (UAS) with high levels of autonomous decision mak- ing. Then, a new framework for risk management of robust autonomy is proposed, which arises from combining quantified measures of risk with normative decision making. The term Robust Autonomy de- scribes the ability of an autonomous system to either continue or abort its operation whilst not breaching a minimum level of acceptable safety in the presence of anomalous conditions. The decision making associ- ated with risk management requires quantifying prob- abilities associated with the measures of risk and also consequences of outcomes related to the behaviour of autonomy. The probabilities are computed from an assessment under both nominal and anomalous sce- narios described by faults, which can be associated with the aircraft’s actuators, sensors, communication link, changes in dynamics, and the presence of other aircraft in the operational space. The consequences of outcomes are characterised by a loss function which rewards the certification decision

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Resumen: La muerte de Alfonso X no significó el cese total de la actividad historiográfica castellana, sino más bien su continuación en una diversidad mayor de centros de producción, no necesariamente impulsados por una figura regia. Si bien hoy no existen testimonios de trabajos cronísticos del período que va desde 1284 hasta mediados del siglo XIII en donde se haga referencia a los reinados de Alfonso X, Sancho IV y Fernando IV, tenemos al menos cuatro crónicas distintas que refieren los hechos ocurridos en esos años, cuyas fuentes deberían haberse redactado en el lapso de tiempo mencionado: la Crónica de tres reyes, la Crónica de los reyes de Castilla de Jofré de Loaysa, la *Historia hasta 1288 dialogada, y la versión que transmite el manuscrito 1342 de la Biblioteca Nacional de Madrid (N3) que Catalán llama Historia en décadas. La enorme diferencia que existe entre estas obras vuelve discutible cualquier aseveración que pretenda establecer una relación genealógica entre unas y otras, lo cual nos obliga a pensar en la existencia de una abundante documentación preexistente en la que los autores se habrían basado para redactar textos que ostensiblemente develan, en un trabajo comparativo que el presente trabajo pretende realizar, orientaciones políticas diversas

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Stair na Gaeilge i gCo. Thiobraid Árann i rith na tréimhse 1700-1901 atá á ríomhadh sa tráchtas seo. Tar éis a cúlra agus a comhthéacs a shuíomh i gCaibidil a hAon, déantar scríobhaithe an cheantair a áireamh, fara tráchtaireacht orthu, i gCaibidil a Dó. I gCaibidlí a Trí agus a Ceathair, féachtar ar thionchar na hEaglaisí Caitlicí agus Eaglais na hÉireann (i measc eaglaisí Protastúnacha eile) ar an dteangain. I gCaibidil a Cúig, faightear spléachadh ar ghnéithe éagsúla de shaíocht an chontae, ag tabhairt léargais ar tháirgí na scríobhaithe, ar leabhair a clóbhualadh sa réigiún, agus ar fhilí móra na háite, leithéidí Liam Daill Uí Ifearnáin, ag sonrú limistéir faoi leith, an t-oirdheisceart, mar shampla. Léirítear éifeacht na gcumann Gaelach agus na ndíograiseoirí iomadúla a bhain leo. Ábhar suime, leis, feidhm na Gaeilge sna cúirteanna dlí. Tugtar faisnéis i gCaibidil a Sé ar fhianaise cuairteoirí ar an Ghaeilge mar urlabhra i dTiobraid Árann. Is anseo chomh maith a deintear anailís ar Dhaonáirimh na mblianta 1861-1901, le mórchuid adhmaid á baint as ceann 1901 go háirithe. Breactar as ainmneacha sagart agus múinteoirí le Gaeilge, agus tráchtar ar aicmí suntasacha eile, na póilíní agus na saighdiúirí a raibh an teanga sin ina mbéal acu. Tugtar le chéile dá réir na snáithíní difriúla eolais ar an dúiche ar bhealach nár tharla cheana don gcontae casta fairsing seo le haghaidh na tréimhse atá idir lámha ag an saothar.

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This chapter argues that the scribes of Lebor na hUidre show a persistent concern with eschatology, and in particular with the salvation of souls and the Last Judgement. In some cases the texts are overtly religious, but in a substantial number of cases they are explicitly or implicitly historical. The pivotal event is the mission of St Patrick, which is identified in several of the texts examined here as the origin of Christianity in Ireland. Pagans are repeatedly brought into contact with Christians/saints or other representatives of God, revealing the victory of Christianity and the subjugation of paganism. It is argued that the stories are to be placed within the medieval western theory of history according to which God’s plan for humanity was revealed through a study of the events of the past.

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When the scribes of ancient Mesopotamia rewrote the Epic of Gilgamesh over a period of over two thousand years, the modifications made reflected the social transformations occurring during the same era. The dethroning of the goddess Inanna-Ishtar and the devaluation of other female characters in the evolving Epic of Gilgamesh coincided with the declining status of women in society. Since the 1960s, translations into modern languages have been readily available. The Mesopotamian myth has been reused in a wide variety of mythic and mythological texts by Quebecois, Canadian and American authors. Our analysis of the first group of mythic texts, written in the 1960s and 1970s, shows a reversal of the tendency of the Mesopotamian texts. Written at a time when the feminist movement was transforming North American society, these retellings feature a goddess with her high status restored and her ancient attributes re-established. Another group of writers, publishing in the 1980s and 1990s, makes a radical shift away from these feminist tendencies while still basically rewriting the Epic. In this group of mythic texts, the goddess and other female characters find their roles reduced while the male gods and characters have expanded and glorified roles. The third group of texts analysed does not rewrite the Epic. The Epic is reused here intertextually to give depth to mythological works set in the twentieth century or later. The dialogue created between the contemporary text and the Epic emphasises the role that the individual has in society. A large-scale comparative mythotextual study of texts that share a common hypotext can, especially when socio-historical factors are considered, provide a window onto the relationship between text and society. A comparative study of how the Epic of Gilgamesh is rewritten and referred to intertextually through time can help us relativize the understanding of our own time and culture.

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Although originally an academic and research product, the WS-PGRADE/gUSE framework is increasingly applied by commercial institutions too. Within the SCI-BUS project, several commercial gateways have been developed by various companies. WS-PGRADE/gUSE is also intensively used within another European research project, CloudSME (Cloud-based Simulation Platform for Manufacturing and Engineering). This chapter provides an overview and de-scribes in detail some commercial WS-PGRADE/gUSE based gateway implemen-tations. Two representative case studies from the SCI-BUS project, the Build and Test portal and the eDOX Archiver Gateway are introduced. An overview of WS-PGRADE/gUSE based gateways for running simulation applications in the cloud within the CloudSME project is also provided.

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Dès ses plus anciennes manifestations, la littérature narrative qui prend le nom de « roman » se donne comme un jeu d’échos et de réponses entre les textes. L’étude des collections de manuscrits permet de saisir ces jeux intertextuels en contexte, notamment à travers l’organisation de codex qui témoignent de la réception du roman médiéval par les copistes médiévaux eux-mêmes. La composition du manuscrit de Chantilly (Condé 472), où se côtoient romans parodiques et romans canoniques (notamment Érec, Yvain et Lancelot de Chrétien de Troyes), illustre le travail de scribes de toute évidence parfaitement conscients du ludisme des textes qu’ils recopiaient et qui s’assuraient, à travers la mise en recueil, de mettre en regard ce que l’on appellerait, en termes genettiens, le texte parodique et sa source hypotextuelle. La mise en recueil donne cependant un sens positif à cette réflexion critique sur l’art du roman : elle ne se contente pas d’organiser la série de romans parodiques de façon à miner la crédibilité du monde arthurien et, ce faisant, de réorienter l’éclairage jeté sur les romans de Chrétien de Troyes, elle propose la lecture allégorique comme voie de renouvellement. Avec les premières branches du Perlesvaus, elle explore les possibilités d’une lecture édifiante de la légende arthurienne, dans un monde où l’humour le cède à l’horreur. Cette voie, abandonnée avant l’heureuse conclusion, est reprise dans un tout autre registre avec le Roman de Renart. La position finale attribuée aux branches du Roman de Renart et le choix de branches où l’enjeu rhétorique et herméneutique est clairement exprimé laissent croire que le scribe qui est derrière l’agencement du manuscrit a trouvé dans les aventures du goupil le juste équilibre entre parodie et allégorie capable de justifier pleinement l’aventure paradoxale du roman antiromanesque.

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Alverata: a typeface design for Europe This typeface is a response to the extraordinarily diverse forms of letters of the Latin alphabet in manuscripts and inscriptions in the Romanesque period (c. 1000–1200). While the Romanesque did provide inspiration for architectural lettering in the nineteenth century, these letterforms have not until now been systematically considered and redrawn as a working typeface. The defining characteristic of the Romanesque letterform is variety: within an individual inscription or written text, letters such as A, C, E and G might appear with different forms at each appearance. Some of these forms relate to earlier Roman inscriptional forms and are therefore familiar to us, but others are highly geometric and resemble insular and uncial forms. The research underlying the typeface involved the collection of a large number of references for lettering of this period, from library research and direct on-site ivestigation. This investigation traced the wide dispersal of the Romanesque lettering tradition across the whole of Europe. The variety of letter widths and weights encountered, as well as variant shapes for individual letters, offered both direct models and stylistic inspiration for the characters and for the widths and weight variants of the typeface. The ability of the OpenType format to handle multiple stylistic variants of any one character has been exploited to reflect the multiplicity of forms available to stonecutters and scribes of the period. To make a typeface that functions in a contemporary environment, a lower case has been added, and formal and informal variants supported. The pan-European nature of the Romanesque design tradition has inspired an pan-European approach to the character set of the typeface, allowing for text composition in all European languages, and the typeface has been extended into Greek and Cyrillic, so that the broadest representation of European languages can be achieved.

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This article examines a common petition presented in the English parliament of 1425 requesting that those imprisoned for long periods for the crimes of treason, felony and Lollardy might be brought to trial. On the basis of palaeographical and orthographical evidence, this petition is demonstrated to be written by Richard Osbarn, clerk of the chamber of the London Guildhall between 1400 and 1437. The implications of this discovery throw new light on the way petitions were formulated, suggesting that the scribes of petitions played a greater role than previously thought, and in some cases identified with the complaint itself.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)