CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa

Chlamydia trachomatis is a significant human pathogen with potentially severe disease sequelae in the genital tract, including infertility. A successful vaccine will need to effectively target immunity to the genital mucosa. Intranasal immunisation with cholera toxin (CT) can target immunity to the genital tract, but has the potential to cause neurological side effects. CTA1-DD is a non-toxic potent mucosal adjuvant which combines the enzymatic properties of CT, with a B cell targeting moiety. Here, we demonstrate that intranasal immunisation with CTA1-DD and chlamydial Major Outer Membrane Protein (MOMP) results in the induction of neutralising systemic and mucosal antibodies, and reduces the level of chlamydial shedding following intravaginal challenge with Chlamydia muridarum. Thus, CTA1-DD is an effective adjuvant for vaccine development against Chlamydia trachomatis, and possibly also a range of other genital pathogens.

Luminosity determination for the dd→αK+K-experiment atANKE/COSY

High resolution studies of a0/f0(980) decays into channels involving open strangeness are currently being performed at COSY-Jülich. As a “filter” for isospin-zero intermediate states, i.e. to selectively produce the f0(980) resonance, the dd→αK+K− reaction was measured with the magnetic ANKE spectrometer. In order to determine the luminosity of this experiment, the elastically and quasi-elastically scattered deuterons were recorded simultaneously with the αK+K− events. Here we report about the luminosity determination via investigating the (quasi-) elastic deuterons at ANKE.

Measurement of the isospin-filtering dd → 4He K+K- reaction at Q = 39 MeV

The total cross-section for the dd → 4HeK+K− reaction has been measured at a beam momentum of 3.7GeV/c, corresponding to an excess energy of 39MeV, which is the maximum possible atthe Cooler Synchrotron COSY-Jülich. A deuterium cluster-jet target and the ANKE forward magnetic spectrometer, placed inside the storage ring, have been employed in this investigation. We find a total cross-section of σtot < 14 pb, which brings into question the viability of investigating the dd → 4He a0(980)reaction as a means of studying isospin violation.

dd→αK+K-反应截面在ANKE/COSY上的测量

ANKE谱仪是位于冷却储存环COSY上的一个内靶实验终端，在它的针对物理目标中，研究靠近 产生阈的共振态a0(980)/f0(980)是一个主要的内容。在通过强相互作用反应对a0/f0进行测量时，初态会选择使用不同的同位旋组合，也就是使用pp、 pn、pd和dd反应。本实验完成于2006年的4、5月间，是一个使用COSY所能提供的最大束流动能Td = 2.273 GeV的dd道反应，它比 产生阈高Q = 39 MeV。在实验中探测了αK+符合事件，结合使用丢失质量分析方法就可以对反应链dd → αf0 → αK+K- 以及其中的f0(980)共振态进行研究。 作为本文的主要内容这个实验，是在Monte - Carlo模拟的帮助下准备后，在4个星期的束流时间里完成的。在实验完成后，数据分析主要集中在对稀有的αK+事件进行鉴别。 ANKE的射程望远镜阵列针对K+介子的鉴别做过优化，在它的帮助下K+就可以通过飞行时间、能量损失方法，以及探测延迟发射的K+衰变产物而被挑选出来。而与之关联的α粒子则是通过它们相对于K+介子的定时点进行鉴别的，α和K+的动量及轨迹由在相应多丝正比室上测量到的径迹信息重建。由此，就可以通过使用丢失质量方法鉴别出实验中没有测量的K-介子。最终所得的αK+丢失质量谱在K-介子质量区域内呈现一个峰，其中包含大约15个事件。由这些αK+K-事件可以得到总的反应截面σtot = (9 ± 3sta ± 5sys) pb。 同位旋破缺反应dd → α(π0η) 的截面由测量得到的σtot (dd → αK+K-)值推出，进而它也给出了在WASA-at-COSY上观察这个过程所要求的最短束流时间。因为这个反应被认为主要是源于通过KK中间态的f0 → a0转化，所以它对于确定出轻标量介子a0(980)/f0(980)的结构扮演着格外重要的角色

1.° Tractatus universalis omnium donationum : authore Mareto, Doctore Tholosano. — 2.° Ejusdem tractatus de testamentis. — 3.° Tractatus Quartarum : eodem authore. — 4.° DD. Cabot ad titulum de impub. et aliis substitutionibus, commentarius. — 5.° Anonymi tractatus de gradibus affinitatis : finis desideratur

Mazarinaeus

1.° Apologia Thomae Basin, Archiepiscopi Caesareensis, anteà Episcopi Lexoviensis, edita anno 1475. ibi multa reperias ad regnum Ludovici XI. Francorum Regis, pertinentia. — 2.° Breviloquium peregrinationis et mansionum XLII. quas in deserto hujus saeculi nequam, habuit Thomas Basin, ambulans per fidem ad speciem et veram terram promissionis : ab eodem editum anno 1488. — 3.° Ejusdem epistola ad Davidem, Episcopum Trajectensem, contra libellum cujusdam Cartusiensis de Remonda, scripta anno 1486. — 4.° Ejusdem libellus de optimo ordine forenses lites audiendi et diffiniendi, ad DD. Petrum de Brezé, magnum Senescallum Normanniae : editus anno 1455.

Colbertinus

1.° Flores chronicorum fusiores ; sive catalogus summorum Pontificum à Christo ad Joannem XXII. authore Bernardo Guidonis. — 2.° Excerpta è collectaneis DD. Nicolai Cardinalis de Aragonia, de aliquorum Pontificum, sive eorum temporum gestis, quae Platina in eorumdem vitis omisit.

Petavianus

Theologia moralis ad mentem DD. Seraphici, & Subtilis concinnata, etin disputationes vigintiocto distributa

UANL