RFID together with multi-agent systems to control global value chains

Nowadays, the cooperative intelligent transport systems are part of a largest system. Transportations are modal operations integrated in logistics and, logistics is the main process of the supply chain management. The supply chain strategic management as a simultaneous local and global value chain is a collaborative/cooperative organization of stakeholders, many times in co-opetition, to perform a service to the customers respecting the time, place, price and quality levels. The transportation, like other logistics operations must add value, which is achieved in this case through compression lead times and order fulfillments. The complex supplier's network and the distribution channels must be efficient and the integral visibility (monitoring and tracing) of supply chain is a significant source of competitive advantage. Nowadays, the competition is not discussed between companies but among supply chains. This paper aims to evidence the current and emerging manufacturing and logistics system challenges as a new field of opportunities for the automation and control systems research community. Furthermore, the paper forecasts the use of radio frequency identification (RFID) technologies integrated into an information and communication technologies (ICT) framework based on distributed artificial intelligence (DAI) supported by a multi-agent system (MAS), as the most value advantage of supply chain management (SCM) in a cooperative intelligent logistics systems. Logistical platforms (production or distribution) as nodes of added value of supplying and distribution networks are proposed as critical points of the visibility of the inventory, where these technological needs are more evident.

Determinantes da separação entre propriedade e gestão nas cooperativas agropecuárias brasileiras

As cooperativas agropecuárias brasileiras geralmente são organizações complexas e de propriedade difusa. Entretanto, 48% dessas organizações não promovem a desvinculação dos proprietários das decisões de gestão, contrariando o que é estabelecido pelo preceito teórico dominante para empresas - cooperativas e não cooperativas - similares. Diante desse desalinhamento, neste artigo investigaram-se os possíveis determinantes da separação entre propriedade e gestão nessas organizações. Na medida em que o processo de separação compreende diferentes relações de agência, foram utilizados respectivamente os modelos logit e tobit para estudar o que determina a delegação do direito de controle formal pelos proprietários ao conselho de administração e a divisão do processo decisório entre os membros do conselho e o executivo responsável pela gestão. Dentre os resultados encontrados, destaca-se o fato de complexidade e propriedade difusa não terem se mostrado relevantes para explicar a separação entre propriedade e gestão, diferentemente do que ocorre em sociedades anônimas. Em contrapartida, características do conselho de administração (tamanho, alocação de autoridade formal, limites à reeleição, reputação e esforço) têm importante papel na determinação da ocorrência de separação. Por tratar-se do primeiro trabalho a abordar o problema do controle em cooperativas agropecuárias, novas pesquisas empíricas são desejáveis.

CASO COCAMAR/PR UMA ANÁLISE DA DISSEMINAÇÃO DO CONHECIMENTO

A presente pesquisa propõe um estudo teórico-empírico em torno da gestão do conhecimento, tendo como recorte o processo de disseminação do conhecimento e a coerência entre o discurso e a prática do princípio cooperativista (educação, formação e informação) como diferenciador na gestão do conhecimento e no modelo organizacional cooperativista. O estudo destina-se a responder três questões: a) como ocorre o processo de disseminação do conhecimento em organizações cooperativas; b) qual a percepção dos colaboradores em relação ao processo de disseminação do conhecimento; e c) como a organização cooperativa investe no desenvolvimento de seu capital intelectual a partir do princípio cooperativista: educação, formação e informação. Assim, o objetivo geral é verificar o processo do conhecimento gestado na cooperativa COCAMAR- PR a partir do princípio cooperativista: educação, formação e informação, enquanto os objetivos específicos foram: levantar como ocorre o processo de disseminação do conhecimento a partir do princípio cooperativista educação, formação e informação ; identificar a percepção dos colabores em relação ao processo de disseminação do conhecimento; e verificar como o processo de disseminação do conhecimento atende às prerrogativas do princípio cooperativista educação, formação e informação . A metodologia escolhida é o estudo de caso, em que se estuda uma organização cooperativa localizada na cidade de Maringá, Estado Paraná. A pesquisa realizada caracteriza-se como um estudo de caso, exploratória e descritiva. Os resultados auferidos na pesquisa pretendem demonstrar o distanciamento da cooperativa em estudo de um de seus princípios fundamentais, embora possua um programa intensivo de capacitação profissional.(AU)

CASO COCAMAR/PR UMA ANÁLISE DA DISSEMINAÇÃO DO CONHECIMENTO

A presente pesquisa propõe um estudo teórico-empírico em torno da gestão do conhecimento, tendo como recorte o processo de disseminação do conhecimento e a coerência entre o discurso e a prática do princípio cooperativista (educação, formação e informação) como diferenciador na gestão do conhecimento e no modelo organizacional cooperativista. O estudo destina-se a responder três questões: a) como ocorre o processo de disseminação do conhecimento em organizações cooperativas; b) qual a percepção dos colaboradores em relação ao processo de disseminação do conhecimento; e c) como a organização cooperativa investe no desenvolvimento de seu capital intelectual a partir do princípio cooperativista: educação, formação e informação. Assim, o objetivo geral é verificar o processo do conhecimento gestado na cooperativa COCAMAR- PR a partir do princípio cooperativista: educação, formação e informação, enquanto os objetivos específicos foram: levantar como ocorre o processo de disseminação do conhecimento a partir do princípio cooperativista educação, formação e informação ; identificar a percepção dos colabores em relação ao processo de disseminação do conhecimento; e verificar como o processo de disseminação do conhecimento atende às prerrogativas do princípio cooperativista educação, formação e informação . A metodologia escolhida é o estudo de caso, em que se estuda uma organização cooperativa localizada na cidade de Maringá, Estado Paraná. A pesquisa realizada caracteriza-se como um estudo de caso, exploratória e descritiva. Os resultados auferidos na pesquisa pretendem demonstrar o distanciamento da cooperativa em estudo de um de seus princípios fundamentais, embora possua um programa intensivo de capacitação profissional.(AU)

CASO COCAMAR/PR UMA ANÁLISE DA DISSEMINAÇÃO DO CONHECIMENTO

A presente pesquisa propõe um estudo teórico-empírico em torno da gestão do conhecimento, tendo como recorte o processo de disseminação do conhecimento e a coerência entre o discurso e a prática do princípio cooperativista (educação, formação e informação) como diferenciador na gestão do conhecimento e no modelo organizacional cooperativista. O estudo destina-se a responder três questões: a) como ocorre o processo de disseminação do conhecimento em organizações cooperativas; b) qual a percepção dos colaboradores em relação ao processo de disseminação do conhecimento; e c) como a organização cooperativa investe no desenvolvimento de seu capital intelectual a partir do princípio cooperativista: educação, formação e informação. Assim, o objetivo geral é verificar o processo do conhecimento gestado na cooperativa COCAMAR- PR a partir do princípio cooperativista: educação, formação e informação, enquanto os objetivos específicos foram: levantar como ocorre o processo de disseminação do conhecimento a partir do princípio cooperativista educação, formação e informação ; identificar a percepção dos colabores em relação ao processo de disseminação do conhecimento; e verificar como o processo de disseminação do conhecimento atende às prerrogativas do princípio cooperativista educação, formação e informação . A metodologia escolhida é o estudo de caso, em que se estuda uma organização cooperativa localizada na cidade de Maringá, Estado Paraná. A pesquisa realizada caracteriza-se como um estudo de caso, exploratória e descritiva. Os resultados auferidos na pesquisa pretendem demonstrar o distanciamento da cooperativa em estudo de um de seus princípios fundamentais, embora possua um programa intensivo de capacitação profissional.(AU)

Prophylactic isolated limb perfusion for localized, high-risk limb melanoma: results of a multicenter randomized phase III trial. European Organization for Research and Treatment of Cancer Malignant Melanoma Cooperative Group Protocol 18832, the World Health Organization Melanoma Program Trial 15, and the North American Perfusion Group Southwest Oncology Group-8593.

PURPOSE: Patients with primary cutaneous melanoma > or = 1.5 mm in thickness are at high risk of having regional micrometastases at the time of initial surgical treatment. A phase III international study was designed to evaluate whether prophylactic isolated limb perfusion (ILP) could prevent regional recurrence and influence survival. PATIENTS AND METHODS: A total of 832 assessable patients from 16 centers entered the study; 412 were randomized to wide excision (WE) only and 420 to WE plus ILP with melphalan and mild hyperthermia. Median age was 50 years, 68% of patients were female, 79% of melanomas were located on a lower limb, and 47% had a thickness > or = 3 mm. RESULTS: Median follow-up duration is 6.4 years. There was a trend for a longer disease-free interval (DFI) after ILP. The difference was significant for patients who did not undergo elective lymph node dissection (ELND). The impact of ILP was clearly on the occurrence-as first site of progression - of in-transit metastases (ITM), which were reduced from 6.6% to 3.3%, and of regional lymph node (RLN) metastases, with a reduction from 16.7% to 12.6%. There was no benefit from ILP in terms of time to distant metastasis or survival. Side effects were higher after ILP, but transient in most patients. There were two amputations for limb toxicity after ILP. CONCLUSION: Prophylactic ILP with melphalan cannot be recommended as an adjunct to standard surgery in high-risk primary limb melanoma.

Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group.

BACKGROUND: Invasive fungal diseases are important causes of morbidity and mortality. Clarity and uniformity in defining these infections are important factors in improving the quality of clinical studies. A standard set of definitions strengthens the consistency and reproducibility of such studies. METHODS: After the introduction of the original European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group definitions, advances in diagnostic technology and the recognition of areas in need of improvement led to a revision of this document. The revision process started with a meeting of participants in 2003, to decide on the process and to draft the proposal. This was followed by several rounds of consultation until a final draft was approved in 2005. This was made available for 6 months to allow public comment, and then the manuscript was prepared and approved. RESULTS: The revised definitions retain the original classifications of "proven," "probable," and "possible" invasive fungal disease, but the definition of "probable" has been expanded, whereas the scope of the category "possible" has been diminished. The category of proven invasive fungal disease can apply to any patient, regardless of whether the patient is immunocompromised, whereas the probable and possible categories are proposed for immunocompromised patients only. CONCLUSIONS: These revised definitions of invasive fungal disease are intended to advance clinical and epidemiological research and may serve as a useful model for defining other infections in high-risk patients.

Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer.

BACKGROUND: Intravenously administered antimicrobial agents have been the standard choice for the empirical management of fever in patients with cancer and granulocytopenia. If orally administered empirical therapy is as effective as intravenous therapy, it would offer advantages such as improved quality of life and lower cost. METHODS: In a prospective, open-label, multicenter trial, we randomly assigned febrile patients with cancer who had granulocytopenia that was expected to resolve within 10 days to receive empirical therapy with either oral ciprofloxacin (750 mg twice daily) plus amoxicillin-clavulanate (625 mg three times daily) or standard daily doses of intravenous ceftriaxone plus amikacin. All patients were hospitalized until their fever resolved. The primary objective of the study was to determine whether there was equivalence between the regimens, defined as an absolute difference in the rates of success of 10 percent or less. RESULTS: Equivalence was demonstrated at the second interim analysis, and the trial was terminated after the enrollment of 353 patients. In the analysis of the 312 patients who were treated according to the protocol and who could be evaluated, treatment was successful in 86 percent of the patients in the oral-therapy group (95 percent confidence interval, 80 to 91 percent) and 84 percent of those in the intravenous-therapy group (95 percent confidence interval, 78 to 90 percent; P=0.02). The results were similar in the intention-to-treat analysis (80 percent and 77 percent, respectively; P=0.03), as were the duration of fever, the time to a change in the regimen, the reasons for such a change, the duration of therapy, and survival. The types of adverse events differed slightly between the groups but were similar in frequency. CONCLUSIONS: In low-risk patients with cancer who have fever and granulocytopenia, oral therapy with ciprofloxacin plus amoxicillin-clavulanate is as effective as intravenous therapy.

A credit union primer; an elementary treatise on cooperative banking, containing questions and answers concerning methods of organization and operation, necessary books and forms, suggested by-laws and the credit union law of New York,

Mode of access: Internet.

Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.

Hepatitis C virus (HCV) NS3-4A is a membrane-associated multifunctional protein harboring serine protease and RNA helicase activities. It is an essential component of the HCV replication complex and a prime target for antiviral intervention. Here, we show that membrane association and structural organization of HCV NS3-4A are ensured in a cooperative manner by two membrane-binding determinants. We demonstrate that the N-terminal 21 amino acids of NS4A form a transmembrane alpha-helix that may be involved in intramembrane protein-protein interactions important for the assembly of a functional replication complex. In addition, we demonstrate that amphipathic helix alpha(0), formed by NS3 residues 12-23, serves as a second essential determinant for membrane association of NS3-4A, allowing proper positioning of the serine protease active site on the membrane. These results allowed us to propose a dynamic model for the membrane association, processing, and structural organization of NS3-4A on the membrane. This model has implications for the functional architecture of the HCV replication complex, proteolytic targeting of host factors, and drug design.

The generation and re-generation of social capital and enterprises in multi-stakeholders social cooperative enterprises: a system dynamic approach

Theories on social capital and on social entrepreneurship have mainly highlighted the attitude of social capital to generate enterprises and to foster good relations between third sector organizations and the public sector. This paper considers the social capital in a specific third sector enterprise; here, multi-stakeholder social cooperatives are seen, at the same time, as social capital results, creators and incubators. In the particular enterprises that identify themselves as community social enterprises, social capital, both as organizational and relational capital, is fundamental: SCEs arise from but also produce and disseminate social capital. This paper aims to improve the building of relational social capital and the refining of helpful relations drawn from other arenas, where they were created and from where they are sometimes transferred to other realities, where their role is carried on further (often working in non-profit, horizontally and vertically arranged groups, where they share resources and relations). To represent this perspective, we use a qualitative system dynamic approach in which social capital is measured using proxies. Cooperation of volunteers, customers, community leaders and third sector local organizations is fundamental to establish trust relations between public local authorities and cooperatives. These relations help the latter to maintain long-term contracts with local authorities as providers of social services and enable them to add innovation to their services, by developing experiences and management models and maintaining an interchange with civil servants regarding these matters. The long-term relations and the organizational relations linking SCEs and public organizations help to create and to renovate social capital. Thus, multi-stakeholder cooperatives originated via social capital developed in third sector organizations produce new social capital within the cooperatives themselves and between different cooperatives (entrepreneurial components of the third sector) and the public sector. In their entrepreneurial life, cooperatives have to contrast the "working drift," as a result of which only workers remain as members of the cooperative, while other stakeholders leave the organization. Those who are not workers in the cooperative are (stake)holders with "weak ties," who are nevertheless fundamental in making a worker's cooperative an authentic social multi-stakeholders cooperative. To maintain multi-stakeholder governance and the relations with third sector and civil society, social cooperatives have to reinforce participation and dialogue with civil society through ongoing efforts to include people that provide social proposals. We try to represent these processes in a system dynamic model applied to local cooperatives, measuring the social capital created by the social cooperative through proxies, such as number of volunteers and strong cooperation with public institutions. Using a reverse-engineering approach, we can individuate the determinants of the creation of social capital and thereby give support to governance that creates social capital.

Low-molecular-weight gelators: Elucidating the principles of gelation based on gelator solubility and a cooperative self-assembly model

This paper highlights the key role played by solubility in influencing gelation and demonstrates that many facets of the gelation process depend on this vital parameter. In particular, we relate thermal stability (T-gel) and minimum gelation concentration (MGC) values of small-molecule gelation in terms of the solubility and cooperative self-assembly of gelator building blocks. By employing a van't Hoff analysis of solubility data, determined from simple NMR measurements, we are able to generate T-calc values that reflect the calculated temperature for complete solubilization of the networked gelator. The concentration dependence of T-calc allows the previously difficult to rationalize "plateau-region" thermal stability values to be elucidated in terms of gelator molecular design. This is demonstrated for a family of four gelators with lysine units attached to each end of an aliphatic diamine, with different peripheral groups (Z or Bee) in different locations on the periphery of the molecule. By tuning the peripheral protecting groups of the gelators, the solubility of the system is modified, which in turn controls the saturation point of the system and hence controls the concentration at which network formation takes place. We report that the critical concentration (C-crit) of gelator incorporated into the solid-phase sample-spanning network within the gel is invariant of gelator structural design. However, because some systems have higher solubilities, they are less effective gelators and require the application of higher total concentrations to achieve gelation, hence shedding light on the role of the MGC parameter in gelation. Furthermore, gelator structural design also modulates the level of cooperative self-assembly through solubility effects, as determined by applying a cooperative binding model to NMR data. Finally, the effect of gelator chemical design on the spatial organization of the networked gelator was probed by small-angle neutron and X-ray scattering (SANS/SAXS) on the native gel, and a tentative self-assembly model was proposed.

Social innovation in local food in Japan: Choku-bai-jo markets and Teikei cooperative practices

The working paper depicts two innovative examples from Japan of the direct supply of food, which involves the development of closer producer-consumer relations, as well as closer producer-producer networks. Choku-bai-jo and Teikei networks are considered as examples of practices implicated in alternative food networks (AFNs). One example has become a quasi-public endeavour and is seen by the Japanese state as a legitimate part of rural development and is promoted in support of small producers. The other is borne from consumer concern over food quality and, despite its long-lived status, this arrangement remains marginal and with little institutional or governmental support. A model which blends the organization and aims of both examples holds potential for a more sustainable eco-economic future.

Measuring the Performance of Cooperative Equity Redemption Plans

Cooperatives differ from other businesses in that they are owned by their patrons and net margins are distributed to patrons on the basis of use instead of capital investment. For financing, cooperatives often rely on allocated equities from retained patronage refunds. Retained patronage refunds are noncash allocations of net margins reinvested in a cooperative by patrons. Under an ideal program of equity formation, equity is held by patrons in proportion to patronage. Each patron’s share of financing the cooperative is equal to the share of benefits received. Equities of former patrons are retired as active patrons take on more of the responsibility of financing the organization.