Sesquiterpenes from Xylaria sp., an endophytic fungus associated with Piper aduncum (Piperaceae)

Two new presilphiperfolane sesquiterpenes, 1 and 2, were isolated from the ethyl acetate extract of Xylaria sp., obtained from the leaves of Piper aduncum, along with two known eremophilane sesquiterpenes, phaseolinone (3) and phomenone (4). Chemical structures of 1 and 2 were established by analysis of spectroscopic data. The four compounds were tested in vitro for antifungal and cytotoxicity activities using CHO (Chinese hamster ovary). Compounds 1 and 2 did not show any antifungal and cytotoxic activity. Compounds 3 and 4 displayed moderate cytotoxic activities, as well as 4 antifungal activity. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

Dihydroisocoumarins produced by Xylaria sp and Penicillium sp., endophytic fungi associated with Piper aduncum and Alibertia macrophylla

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Sesquiterpenes from Xylaria sp., an endophytic fungus associated with Piper aduncum (Piperaceae)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Substâncias antifúngicas de Xylaria sp., um fungo endofítico isolado de Palicourea marcgravii (Rubiaceae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo visando a otimização do solvente extrator e estudo preliminar sobre a quantificação da citocalasina D produzida pelo endófito Xylaria sp., usando a técnica de RMN de '1 SOB H'

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo químico e avaliação biológica dos fungos endofíticos Xylaria sp. e Colletotrichum crassipes isolados de Casearia sylvestris (Flacourtiaceae)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Exploração racional da rede metabólica de Xylaria sp. visando à produção de metabólitos de interesse farmacológico através de ferramentas quimiométricas e técnicas de desreplicação

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Asymmetric microbial reduction of ketones: absolute configuration of trans-4-ethyl-1-(1S-hydroxyethyl)cyclohexanol

A set of five fungal species, Botrytis cinerea, Trichoderma viride and Eutypa lata, and the endophytic fungi Colletotrichum crassipes and Xylaria sp., was used in screening for microbial biocatalysts to detect monooxygenase and alcohol dehydrogenase activities (for the stereoselective reduction of carbonyl compounds). 4-Ethylcyclohexanone and acetophenone were biotransformed by the fungal set. The main reaction pathways involved reduction and hydroxylations at several positions including tertiary carbons. B. cinerea was very effective in the bioreduction of both substrates leading to the chiral alcohol (S)-1-phenylethanol in up to 90% enantiomeric excess, and the cis-trans ratio for 4-ethylcyclohexanol was 0:100. trans-4-Ethyl-1-(1S-hydroxyethyl)cyclohexanol, obtained from biotransformation by means of an acyloin-type reaction, is reported here for the first time. The absolute configurations of the compounds trans-4-ethyl-1-(1S-hydroxyethyl)cyclohexanol and 4-(1S- and 4-(1R-hydroxyethyl)cyclohexanone were determined by NMR analysis of the corresponding Mosher's esters. (C) 2009 Elsevier Ltd. All rights reserved.

Seleção de fungos degradadores de madeira para uso na destoca biológica de Eucalyptus spp

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação do potencial biocatalítico de fungos endófitos de espécies vegetais do Cerrado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Busca de substâncias bioativas em fungos associados com a espécie Michelia champaca L. (Magnoliaceae)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Biodegradation of eucalyptus urograndis wood by fungi

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Taxonomia e potencial antimicrobiano de fungos depositados no acervo de pesquisa da Central de Recursos Microbianos da UNESP

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)