Ockham on Aristotle's Physics : a translation of Ockham's Brevis summa libri physicorum /

Includes bibliographical references (p. [141]-142).

Sovereignty and power relations in the thought of Marsilius of Padua and William of Ockham a comparison.

pp. 229-253

Guillelmi de Occam Breviloquium de potestate papæ,

Mode of access: Internet.

Quotlibeta septem ; vna cum tractatu de sacramento altaris / venerabilis inceptoris fratris Guilhelmi de Ockam anglici sacre theologie magistri de ordine fratrum minoru[m].

Lugar y fecha de imp. tomados del colofón

Tractat[us] / venerabilis Inceptoris Guilhelmi ocka[m] desacramento altaris.

Huecos para iniciales con letras de aviso

Tabule ad diuersas huius operis magistri Guilhelmi de ockam sup[er] quattuor libros s[e]n[tent]iaru[m] a[n]notat[i]o[n]es et ad ce[n]tilogij theologici eiusdem co[n]clusiones facile reperiendas apprime conducibiles.

Pie de imp. tomado del colofón en X10r

Explicit tractatus logice / fratris guillermi ockan ; diuisus in tres p[ar]tes et vnaqueq[ue] pars p[er] capitula distincta est.

Huecos para iniciales con letras de aviso

Guillaume d'Occam; sa vie, ses œuvres, ses idées sociales et politiques.

"Bibliographie": v.1, p.[273]-306.

La ontología del espíritu: principio de epistemología de G. de Ockham

El principio radical de toda la filosofía de Ockham no es ni una metafísica del singular, ni una actitud logicista, teologal oescéptica. El Inceptor es la culminación de una tendencia neoplatónica, también central en el Eriúgena: aun para la creatura humanalo "inteligente" es anterior y ontológicamente superior a lo "inteligible" o "sensible".Heredado de Agustín de Hipona, pero transformado en el análisis hasta ser inmediato precedente de la Modernidad o comienzo de ella, el "yo pienso" es el quicio del sistema de Ockman. De la exacta acotación moderna de "espíritu" arranca todo el sistema; a partir de él se justifican incluso los rasgos que más sorprende hallar en un filósofo del siglo XIV: la centralidad de las nociones opuestas "intuición/evidencia", la plena actividad cognoscitiva del espíritu junto a la pasividad del intelecto, la nula causalidad próxima de las cosas sensibles en el conocimiento humano, e! paradigma perfectamente lingüístico del conocer. El nacimiento de una moderna "teoría del conocimiento", se da a partir de la constatación de que el acto más perfecto y paradigmáticode la vida del espíritu es la intuición de los "intellectualia" que radican en él mismo, y no la captación de los externos "sensibilia" aristotélicos.

Calibration and application of B/Ca, Cd/Ca, and d11B in Neogloboquadrina pachyderma (sinistral)

The North Atlantic and Norwegian Sea are prominent sinks of atmospheric CO2 today, but their roles in the past remain poorly constrained. In this study, we attempt to use B/Ca and d11B ratios in the planktonic foraminifera Neogloboquadrina pachyderma (sinistral variety) to reconstruct subsurface water pH and pCO2 changes in the polar North Atlantic during the last deglaciation. Comparison of core-top results with nearby hydrographic data shows that B/Ca in N. pachyderma (s) is mainly controlled by seawater [B(OH)4]?/[HCO3]? with a roughly constant partition coefficient (KD =([B/Ca]of CaCO3)/([B(OH)4]-/[HCO3]-)of seawater) of 1.48 ± 0.15 * 10**-3 (2sigma), and d11B in this species is offset below d11B of the borate in seawater by 3.38 ± 0.71 per mil (2sigma). These values represent our best estimates with the sparse available hydrographic data close to our core-tops. More culturing and sediment trap work is needed to improve our understanding of boron incorporation into N. pachyderma (s). Application of a constant KD of 1.48 * 10**-3 to high resolution N. pachyderma (s) B/Ca records from two adjacent cores off Iceland shows that subsurface pCO2 at the habitat depth of N. pachyderma (s) (~50 m) generally followed the atmospheric CO2 trend but with negative offsets of ~10-50 ppmv during 19-10 ka. These B/Ca-based reconstructions are supported by independent estimates from low-resolution d11B measurements in the same cores. We also calibrate and apply Cd/Ca in N. pachyderma (s) to reconstruct nutrient levels for the same down cores. Like today's North Atlantic, past subsurface pCO2 variability off Iceland was significantly correlated with nutrient changes that might be linked to surface nutrient utilization and mixing within the upper water column. Because surface pCO2 (at 0 m water depth) is always lower than at deeper depths and if the application of a constant KD is valid, our results suggest that the polar North Atlantic has remained a CO2 sink during the calcification seasons of N. pachyderma (s) over the last deglaciation.

The correspondence between the commissioners of the state of So. Ca. to the government at Washington and the President of the United States; together with the statement of Messrs. Miles and Keitt. Printed by order of the Convention.

Commissioners: R.W. Barnwell, J.H. Adams, James L. Orr.

Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure

Aims: The clinical benefits of angiotensin II type 1 (AT1) receptor blockers (ARB) in heart failure (HF) include cardiac anti-remodeling and improved ventricular function. However, the cellular mechanisms underlying the benefits of ARB on ventricular function need to be better clarified. In the present manuscript, we evaluated the effects of AT1 receptor blockade on the net balance of Ca(2+) handling proteins in hearts of mice lacking alpha(2A) and alpha(2C) adrenoceptors (alpha(2A)/alpha(2C)ARKO), which develop sympathetic hyperactivity (SH) induced-HF. Main methods: A cohort of male wild-type (WT) and congenic alpha(2A)/alpha(2C)ARKO mice in a C57BL6/J genetic background (5-7 mo of age) was randomly assigned to receive either placebo or ARB (Losartan, 10 mg/kg for 8wks). Ventricular function (VF) was assessed by echocardiography, and cardiac myocyte width and ventricular fibrosis by a computer-assisted morphometric system. Sarcoplasmic reticulum Ca(2+) ATPase (SERCA2), phospholamban (PLN), phospho-Ser(16)-PLN, phospho-Thr(17)-PLN, phosphatase 1 (PP1), Na(+)-Ca(2+) exchanger (NCX), Ca(2+)/calmodulin-dependent protein kinase 11 (CaMKII) and phospho-Thr(286)-CaMKII were analyzed by Western blot. Key findings: alpha(2A)/alpha(2C)ARKO mice displayed ventricular dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis paralleled by decreased SERCA2 and increased phospho-Thr(17)-PLN, CaMKII, phospho-Thr(286)-CaMKII and NCX levels. ARB induced anti-cardiac remodeling effect and improved VF in alpha(2A)/alpha(2C)ARKO associated with increased SERCA2 and phospho-Ser(16)-PLN levels, and SERCA2:NCX ratio. Additionally, ARB decreased phospho-Thr(17)-PLN levels as well as reestablished NCX, CaMKII and phospho-Thr(286)-CaMKII toward WT levels. Significance: Altogether, these data provide new insights on intracellular Ca(2+) regulatory mechanisms underlying improved ventricular function by ARB therapy in HF. (c) 2011 Elsevier Inc. All rights reserved.

Phase and microstructural evolution during the heat treatment of Sm-Ca-alpha-sialon ceramics

The phase and microstructural evolution of multi-cation Sm-Ca-alpha-sialon ceramics was investigated. Six samples were prepared, ranging from a pure Sm-sialon to a pure Ca-sialon, with calcium replacing samarium in 20 eq% increments, thus maintaining an equivalent design composition in all samples. After pressureless sintering at 1820 degreesC for 2 It, all samples were subsequently heat treated up to 192 h at 1450 and 1300 degreesC. The amount of grain boundary glass in the samples after sintering was observed to decrease with increasing calcium levels. A M-ss' or M-ss',-gehlenite solid solution was observed to form during the 1450 degreesC heat treatment of all Sm-containing samples, and this phase forms in clusters in the high-Sm samples. The thermal stability of the alpha-sialon phase was improved in the multi-cation systems. Heat treatment at 1300 degreesC produces SmAlO3 in the high-Sm samples, a M-ss',-gehlenite solid solution in the high-Ca samples, and a Sm-Ca-apatite phase in some intermediate samples. (C) 2002 Elsevier Science Ltd. All rights reserved.

Mitochondrial localization ot two brain proteins, p42IP4/centaurin-[alpha]1/ADAP1 and CNP, and their involvement in regulation of mitochondrial Ca 2+

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2010

Expression, purification and biochemical characterization of recombinant Ca-dependent protein kinase 2 of the malaria parasite Plasmodium falciparum.

Calcium-dependent protein kinases (CDPKs) are serine/threonine kinases that react in response to calcium which functions as a trigger for several mechanisms in plants and invertebrates, but not in mammals. Recent structural studies have defined the role of calcium in the activation of CDPKs and have elucidated the important structural changes caused by calcium in order to allow the kinase domain of CDPK to bind and phosphorylate the substrate. However, the role of autophosphorylation in CDPKs is still not fully understood. In Plasmodium falciparum, seven CDPKs have been identified by sequence comparison, and four of them have been characterized and assigned to play a role in parasite motility, gametogenesis and egress from red blood cells. Although PfCDPK2 was already discovered in 1997, little is known about this enzyme and its metabolic role. In this work, we have expressed and purified PfCDPK2 at high purity in its unphosphorylated form and characterized its biochemical properties. Moreover, propositions about putative substrates in P. falciparum are made based on the analysis of the phosphorylation sites on the artificial substrate myelin basic protein (MBP).