847 resultados para White Plains
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Mode of access: Internet.
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Includes bibliographies.
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Mode of access: Internet.
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Aerial view to horizon.
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Nat Gold graduated from the Sheet Metal program at the New York Trade School in 1942. He is represented here in the sheet metal shop he owns. Notice the blueprints for the White Plains Senior High School hanging on the wall behind him. Original caption reads, "Shop Owner, Brook Sheet Metal Inc. Nat Gold - Sheet Metal 1942, represents one of many Sheet Metal graduates who became owners of their own business." Black and white photograph.
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Background The malignant B cells in chronic lymphocytic leukemia receive signals from the bone marrow and lymph node microenvironments which regulate their survival and proliferation. Characterization of these signals and the pathways that propagate them to the interior of the cell is important for the identification of novel potential targets for therapeutic intervention. Design and Methods We compared the gene expression profiles of chronic lymphocytic leukemia B cells purified from bone marrow and peripheral blood to identify genes that are induced by the bone marrow microenvironment. Two of the differentially expressed genes were further studied in cell culture experiments and in an animal model to determine whether they could represent appropriate therapeutic targets in chronic lymphocytic leukemia. Results Functional classification analysis revealed that the majority of differentially expressed genes belong to gene ontology categories related to cell cycle and mitosis. Significantly up-regulated genes in bone marrow-derived tumor cells included important cell cycle regulators, such as Aurora A and B, survivin and CDK6. Down-regulation of Aurora A and B by RNA interference inhibited proliferation of chronic lymphocytic leukemia-derived cell lines and induced low levels of apoptosis. A similar effect was observed with the Aurora kinase inhibitor VX-680 in primary chronic lymphocytic leukemia cells that were induced to proliferate by CpG-oligonucleotides and interleukin-2. Moreover, VX-680 significantly blocked leukemia growth in a mouse model of chronic lymphocytic leukemia. Conclusions Aurora A and B are up-regulated in proliferating chronic lymphocytic leukemia cells and represent potential therapeutic targets in this disease.
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1 Brief von Max Horkheimer an das Californian Hotel Fresno, 20.07.1947; 1 Brief von Franz Calvelli-Adorno an Max Horkheimer, 1948; 1 Brief von der Cambridge Univerity Press London an Max Horkheimer, 09.06.1940; 1 Brief vonMax Horkheimer an C.E. De Camp, 09.12.1940; 1 Brief von Max Horkheimer an Hadley Cantril, 09.01.1939; 5 Briefe zwischen William Charles Carlé und Max Horkheimer, 1939-1944; 1 Brief von Rose Carter an Max Horkheimer, 20.04.1940; 3 Briefe zwischen der Central Westchester Human Society, White Plains, NY und Max Horkheimer, 1939; 1 Brief von Frank F. Charles an Max Horkheimer, 16.03.1939; 7 Briefe zwischen der Charity Organisation Society London und Max Horkheimer, 1936-1938; 1 Brief von Christa Christian an Max Horkheimer, 12.11.1937; 4 Briefe zwischen Ada Citroen-Kater und Max Horkheimer, 1940; 7 Briefe zwsichen Fenny van Leer und Max Horkheimer, 1940; 3 Briefe zwischen Leo Löwenthal an Frieda Fromm-Reichmann, 1940, 13.11.1940; 1 Brief von Leo Löwenthal an David Reissner, 05.09.1940; 21 Briefe zwischen dem City Club of New York und Max Horkheimer, 1938-1940; 1 Brief von Max Horkheimer an das City College of New York, 20.11.1940; 1 Brief von Max Horkheimer an Charles Upson Clark, 04.06.1938; 2 Briefe zwischen Morris R. Cohen und Max Horkheimer, 16.02.1939, 24.03.1941; 7 Briefe zwischen Alfred E. Cohn und Max Horkheimer, 1939-1941; 1 Brief und 1 Entwurf von Max Horkheimer an Else Cohnstaedt, März 1941; 1 Brief von dem College of the Pacific California an Max Horkheimer, 01.03.1949; 10 Briefe zwischen Gerhard Colm und Max Horkheimer, 1935-1939; 1 Brief von Gerhard Colm an Georg Rusche, 19.09.1938;
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While logic programming languages offer a great deal of scope for parallelism, there is usually some overhead associated with the execution of goals in parallel because of the work involved in task creation and scheduling. In practice, therefore, the "granularity" of a goal, i.e. an estimate of the work available under it, should be taken into account when deciding whether or not to execute a goal concurrently as a sepárate task. This paper describes a method for estimating the granularity of a goal at compile time. The runtime overhead associated with our approach is usually quite small, and the performance improvements resulting from the incorporation of grainsize control can be quite good. This is shown by means of experimental results.
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This layer is a georeferenced raster image of the historic paper map entitled: New York City and vicinity, H.M. Wilson, geographer in charge ; triangulation by U.S. Coast and Geodetic Survey ; topography by S.H. Bodfish ... [et al. and] U.S. Coast and Geodetic Survey, N.Y. City Government and the Geological Survey of New Jersey. It was published by U.S.G.S. in 1899. Scale 1:62,500. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD83 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, cities and towns, villages, forts, cemeteries, aqueducts, boundaries, and more. Relief is shown with standard contour intervals of 20 feet. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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This layer is a georeferenced raster image of the United States Geological Survey 7.5 minute topographic sheet map entitled: New York and vicinity : Harlem, N.Y.-N.J., 1956. It is part of an 8 sheet map set covering the metropolitan New York City area. It was published in 1961. Scale 1:24,000. The source map was compiled from 1:24,000-scale maps of Mount Vernon 1956, Yonkers 1956, Central Park 1956, and Flushing 1955 7.5 minute quadrangles. Hydrography compiled from USC&GS charts 222 (1955), 223 (1954), 748 (1955), 226, 274, 745, 746, and 747 (1956). The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD27 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. USGS maps are typical topographic maps portraying both natural and manmade features. They show and name works of nature, such as mountains, valleys, lakes, rivers, vegetation, etc. They also identify the principal works of humans, such as roads, railroads, boundaries, transmission lines, major buildings, etc. Relief is shown with standard contour intervals of 10 and 20 feet; depths are shown with contours and soundings. Please pay close attention to map collar information on projections, spheroid, sources, dates, and keys to grid numbering and other numbers which appear inside the neatline. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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This layer is a georeferenced raster image of the United States Geological Survey 7.5 minute topographic sheet map entitled: New York and vicinity : Oyster Bay, N.Y.-Conn., 1955. It is part of an 8 sheet map set covering the metropolitan New York City area. It was published in 1961. Scale 1:24,000. The source map was prepared by the Geological Survey from 1:24,000-scale maps of Bayville 1954, Mamaroneck 1955, Sea Cliff 1954, and Hicksville 1954 7.5 minute quadrangles compiled by the Army Map Service. The Mamaroneck quadrangle was previously compiled by the Geological Survey in 1933 and 1934. Culture revised by the Geological Survey. Hydrography compiled from USC&GS charts 222 (1955), 223 (1954, 1955), and 224 (1954). The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 18N NAD27 projection. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. USGS maps are typical topographic maps portraying both natural and manmade features. They show and name works of nature, such as mountains, valleys, lakes, rivers, vegetation, etc. They also identify the principal works of humans, such as roads, railroads, boundaries, transmission lines, major buildings, etc. Relief is shown with standard contour intervals of 10 and 20 feet; depths are shown with contours and soundings. Please pay close attention to map collar information on projections, spheroid, sources, dates, and keys to grid numbering and other numbers which appear inside the neatline. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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Mode of access: Internet.
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Published in White Plains, N.Y., Nov. 1914-June 1917; in New York, Jan. 1918-
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Edited by Edith M. Phelps and Ruth Ulman [et al]