62 resultados para Whately


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Mode of access: Internet.

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Mode of access: Internet.

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Mode of access: Internet.

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New ed., 1868, in 1 v., abridged and revised.

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AIM: To test the hypothesis that a 'basal plus' regimenadding once-daily main-meal fast-acting insulin to basal insulin once dailywould be non-inferior to biphasic insulin twice daily as assessed by glycated haemoglobin (HbA1c) concentration (predefined as ≤0.4%), but would provide superior treatment satisfaction. METHODS: This open-label trial enrolled adults to an 8- or 12-week run-in period, during which oral therapies except metformin were stopped and insulin glargine dose was titrated. Those with fasting glucose <7 mmol/l but HbA1c >7% (53 mmol/mol) were randomized to insulin glargine/glulisine once daily (n = 170) or insulin aspart/aspart protamine 30/70 twice daily (n = 165) for 24 weeks, with dose titration to glucose targets using standardized algorithms. RESULTS: For HbA1c, the basal plus regimen was non-inferior to biphasic insulin (least squares mean difference, 0.21%, upper 97.5% confidence limit 0.38%) meeting the predefined non-inferiority margin of 0.4%. Treatment satisfaction (Diabetes Treatment Satisfaction Questionnaire change version and Insulin Treatment Satisfaction Questionnaire total scores) significantly favoured basal plus. No difference was observed between the basal plus and the biphasic insulin groups in responders (HbA1c <7%, 20.6 vs 27.9%; p = 0.12), weight gain (2.06 vs 2.50 kg; p = 0.2), diabetes-specific quality of life (Audit of Diabetes-Dependent Quality of Life average weighted impact (AWI) score) and generic health status (five-dimension European Quality of Life questionnaire). Overall hypoglycaemia rates were similar between groups (15.3 vs 18.2 events/patient-year; p = 0.22); nocturnal hypoglycaemia was higher with the basal plus regimen (5.7 vs 3.6 events/patient-year; p = 0.02). CONCLUSION: In long-standing type 2 diabetes with suboptimal glycaemia despite oral therapies and basal insulin, the basal plus regimen was non-inferior to biphasic insulin for biomedical outcomes, with a similar overall hypoglycaemia rate but more nocturnal events.

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Este trabalho explora a solução do problema de sub-investimento em novos plantios florestais no Brasil, por meio de empresas especializadas na gestão de ativos florestais. Com a redução dos novos plantios e a crescente demanda por produtos da indústria de base florestal, a oferta de madeira no país deve tornar-se insuficiente para atender a demanda no mercado interno. Programas governamentais de subsídio de crédito e programas privados de fomento florestal visam atrair novos participantes para o negócio das florestas plantadas, porém, essas iniciativas são insuficientes. Este trabalho explora a alternativa de organizar-se o investimento e a gestão dos ativos florestais por meio de empresas especializadas nesta função econômica. No caso dos EUA, vem crescendo a participação dos ativos florestais administrados por empresas organizadas na forma de TIMOs ou Timber REITs, que adquirem grandes áreas de florestas com os recursos de investidores institucionais. Estes investidores são atraídos pelo histórico de retorno desses investimentos e seu potencial para diversificação de carteiras. No Brasil, esses veículos devem ser adequados às necessidades do setor florestal brasileiro, caracterizado pela concentração da propriedade das florestas plantadas nas mãos de grandes empresas integradas, cuja grande parte da produção de madeira é destinada ao consumo próprio. Neste trabalho procurou-se sugerir a securitização de recebíveis florestais como alternativa para a criação desses veículos de investimento no Brasil. Esta alternativa poderia atender os interesses das empresas de base florestal, dos investidores institucionais, fundos de private equity e outros. São estudados casos desta operação na Europa e EUA. Para as empresas integradas, a securitização e a gestão independente das florestas permitiram a liberação de recursos para investimento em seus core businesses e contribuíram para a redução do custo de capital.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

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The present study has as objective to explaining about the origins of the mathematical logic. This has its beginning attributed to the autodidactic English mathematician George Boole (1815-1864), especially because his books The Mathematical Analysis of Logic (1847) and An Investigation of the Laws of Thought (1854) are recognized as the inaugural works of the referred branch. However, surprisingly, in the same time another mathematician called Augutus of Morgan (1806-1871) it also published a book, entitled Formal Logic (1847), in defense of the mathematic logic. Even so, times later on this same century, another work named Elements of Logic (1875) it appeared evidencing the Aristotelian logic with Richard Whately (1787-1863), considered the better Aristotelian logical of that time. This way, our research, permeated by the history of the mathematics, it intends to study the logic produced by these submerged personages in the golden age of the mathematics (19th century) to we compare the valid systems in referred period and we clarify the origins of the mathematical logic. For that we looked for to delineate the panorama historical wrapper of this study. We described, shortly, biographical considerations about these three representatives of the logic of the 19th century formed an alliance with the exhibition of their point of view as for the logic to the light of the works mentioned above. In this sense, we aspirated to present considerations about what effective Aristotelian´s logic existed in the period of Boole and De Morgan comparing it with the new emerging logic (the mathematical logic). Besides of this, before the textual analysis of the works mentioned above, we still looked for to confront the systems of Boole and De Morgan for we arrive to the reason because the Boole´s system was considered better and more efficient. Separate of this preponderance we longed to study the flaws verified in the logical system of Boole front to their contemporaries' production, verifying, for example, if they repeated or not. We concluded that the origins of the mathematical logic is in the works of logic of George Boole, because, in them, has the presentation of a new logic, matematizada for the laws of the thought similar to the one of the arithmetic, while De Morgan, in your work, expand the Aristotelian logic, but it was still arrested to her

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This layer is a georeferenced raster image of the historic paper map entitled: Map of Franklin County, Massachusetts : based upon the trigonometrical survey of the state, the details from actual surveys under the direction of H.F. Walling, supt. of the state map. It was published by Smith & Ingraham in 1858. Scale [ca. 1:47,520]. This layer is image 1 of 3 total images, representing the northwest portion of the four sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and school district boundaries, and more. Relief shown by hachures. It includes many cadastral insets of individual county towns and villages. It also includes illustrations, business directories, and tables of statistics and distances.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

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This layer is a georeferenced raster image of the historic paper map entitled: Map of Franklin County, Massachusetts : based upon the trigonometrical survey of the state, the details from actual surveys under the direction of H.F. Walling, supt. of the state map. It was published by Smith & Ingraham in 1858. Scale [ca. 1:47,520]. This layer is image 3 of 3 total images, representing the northeast portion of the four sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), private buildings with names of property owners, town and school district boundaries, and more. Relief shown by hachures. It includes many cadastral insets of individual county towns and villages. It also includes illustrations, business directories, and tables of statistics and distances.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

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This layer is a digital raster graphic of the historic 15-minute USGS topographic map of the Northampton, Massachusetts quadrangle. The survey date (ground condition) of the original paper map is 1884-1885, the edition date is July, 1895 and this map has a reprint date of April 1909. A digital raster graphic (DRG) is a scanned image of a U.S. Geological Survey (USGS) standard series topographic map, including all map collar information. The image inside the map neatline is geo-referenced to the surface of the earth and fit to the Universal Transverse Mercator projection. The horizontal positional accuracy and datum of the DRG matches the accuracy and datum of the source map.