Westborough state hospital papers; a testimonial to George Smith Adams, M.D.

"Reprinted from New England medical gazette. vol. XLVII, pp.467-686.".

Vital records of Westborough, Massachusetts, to the end of the year 1849.

Mode of access: Internet.

The hundredth town. Glimpses of life in Westborough. 1717-1817.

Mode of access: Internet.

Comparison of multiplex ligation-dependent probe amplification and real-time PCR accuracy for gene copy number quantification using the beta-defensin locus

The reliable quantification of gene copy number variations is a precondition for future investigations regarding their functional relevance. To date, there is no generally accepted gold standard method for copy number quantification, and methods in current use have given inconsistent results in selected cohorts. In this study, we compare two methods for copy number quantification. beta-defensin gene copy numbers were determined in parallel in 80 genomic DNA samples by real-time PCR and multiplex ligation-dependent probe amplification (MLPA). The pyrosequencing-based paralog ratio test (PPRT) was used as a standard of comparison in 79 out of 80 samples. Realtime PCR and MPLA results confirmed concordant DEFB4, DEFB103A, and DEFB104A copy numbers within samples. These two methods showed identical results in 32 out of 80 samples; 29 of these 32 samples comprised four or fewer copies. The coefficient of variation of MLPA is lower compared with PCR. In addition, the consistency between MLPA and PPRT is higher than either PCR/MLPA or PCR/PPRT consistency. In summary, these results suggest that MLPA is superior to real-time PCR in beta-defensin copy number quantification.

Student notebook of Ebenezer Parkman, 1720

The small hardcover notebook contains a manuscript copy of Charles Morton's Natural Philosophy copied by student Ebenezer Parkman (Harvard Class of 1721) in 1720, as well as notes on Hebrew grammar. The flyleaf has a faded note, "[This copy] was probably made by Parkman H.U. 1721 afterward minister of Westboro." The title page of the volume includes the handwritten title "Phylosophia Natvralis: Naturall Philosophy, By the Reverd Mr. Charles Morton Pastor of a Church in Charles Town, Beegan [sic] to recite it December 11, 1720 Willm Brattle's Book 1720 ended January 30 Anno Domini 1720 [January 30, 1720/1721]." The final page of the transcription is signed and dated "June 18, 1720 Parkman." The last pages of the volume consist of notes on Hebrew Grammar titled "Instruction in Hebrew."

Account book of Daniel Brigham, 1781-1798 (inclusive)

Account book maintained by Dr. Daniel Brigham (1760-1830) for services provided to approximately 180 patients, treated primarily in Northborough, Westborough, and Marlborough, Massachusetts, and surrounding towns between 1781 and 1798. The ledger details the charges for his visits to patients and medicines he prescribed. Common charges included one shilling, four pence for Brigham to visit and administer an emetic or cathartic to a patient. A visit and bloodletting by Brigham cost one patient two shillings, eight pence. He charged six shillings to amputate a toe, and eight pence to extract a tooth. Includes an index to patient names. The ledger also records household and miscellaneous expenses of Brigham.

Doctor Daniel Brigham's Book, 1789-1810 (inclusive)

Ledger maintained by Dr. Daniel Brigham (1760-1837) containing financial accounts for medical patients treated primarily in Northborough, Westborough, and Marlborough, Massachusetts from 1789 to 1837. The ledger details the charges for medical services and the corresponding payments, often made by payment-in-kind. Common charges included a shilling for a visit and administration of cathartics, emetics, or anodynes. Extraction of a tooth cost eight pence, and Brigham charged one woman nine shillings for delivering her son. A number of entries are obscured by pasted-in newspaper articles.

Blackstone, Massachusetts 15 Minute Digital Raster Graphic

This layer is a digital raster graphic of the historic 15-minute USGS topographic map of the Blackstone, Massachusetts quadrangle. The survey date (ground condition) of this map is 1886 and the edition date is October, 1893. A digital raster graphic (DRG) is a scanned image of a U.S. Geological Survey (USGS) standard series topographic map, including all map collar information. The image inside the map neatline is geo-referenced to the surface of the earth and fit to the Universal Transverse Mercator projection. The horizontal positional accuracy and datum of the DRG matches the accuracy and datum of the source map. The names of quadrangles which border this one appear on the map collar in their respective positions (N,S,E,W) in relation to this map.

Marlboro, Massachusetts 15 Minute Digital Raster Graphic

This layer is a digital raster graphic of the historic 15-minute USGS topographic map of the Marlboro, Massachusetts quadrangle. The survey date (ground condition) of the original paper map is 1886-87, the edition date is June, 1898 and this map has a reprint date of August, 1914. A digital raster graphic (DRG) is a scanned image of a U.S. Geological Survey (USGS) standard series topographic map, including all map collar information. The image inside the map neatline is geo-referenced to the surface of the earth and fit to the Universal Transverse Mercator projection. The horizontal positional accuracy and datum of the DRG matches the accuracy and datum of the source map.

Report

Issued by the Hospital under Its Earlier Names: 1884/85-19 , Westborough Insane Hospital; 1910/11-1939/40, Westborough State Hospital