Granular flow and design studies in flighted rotating drums

Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2013

Structure-based drug design studies of the interactions ofent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparumsarco/endoplasmic reticulum Ca2+-ATPase PfATP6

Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though hampered by a lack of knowledge regarding the molecular mechanisms of artemisinin resistance. Semisynthetic compounds derived from diterpenes from the medicinal plant Wedelia paludosawere tested in silico against the Plasmodium falciparumCa2+-ATPase, PfATP6. This protein was constructed by comparative modelling using the three-dimensional structure of a homologous protein, 1IWO, as a scaffold. Compound 21 showed the best docking scores, indicating a better interaction with PfATP6 than that of thapsigargin, the natural inhibitor. Inhibition of PfATP6 by diterpene compounds could promote a change in calcium homeostasis, leading to parasite death. These data suggest PfATP6 as a potential target for the antimalarial ent-kaurane diterpenes.

Summer Institute for Graphic Design Studies / Nowroozi

Summer Graphic Design workshops Co-sponsored by the Continuing Education Division and the Graphic Design Dept. Schedule C & D, three weeks each, tuition $550-$650.00, New Times in London $1,735.00

Summer Institute for Graphic Design Studies / Nowroozi (reverse)

Summer Graphic Design workshops Co-sponsored by the Continuing Education Division and the Graphic Design Dept. Schedule C & D, three weeks each, tuition $550-$650.00, New Times in London $1,735.00

Summer Institute for Graphic Design Studies / Don Adleta

Summer Graphic Design workshops Co-sponsored by the Continuing Education Division and the Graphic Design Dept. Schedule A & B, tuition $410.00, Applied Semiotics for Design Seminar $625.00

Summer Institute for Graphic Design Studies / Nowroozi

Summer Graphic Design workshops Co-sponsored by the Continuing Education Division and the Graphic Design Dept. Schedule B, C & D, tuition $450.00

Summer Institute for Graphic Design Studies / Nowroozi (reverse)

Summer Graphic Design workshops Co-sponsored by the Continuing Education Division and the Graphic Design Dept. Schedule B, C & D, tuition $450.00

Design studies of the magnetic properties of structural materials affecting the magnetic field of high-homogeneity superconducting magnets

Austenitic stainless steel presents phase changes caused by heat treatment and welding processes. Because it represents a problem in the design of high-homogeneity magnets, we have been studying the magnetic properties of Ti alloys for their use instead of stainless steel as structural material for superconducting magnet construction. In this work, we present the comparative study of the influence of magnetic properties of steel and Ti alloys on the magnetic-field homogeneity of a superconducting coil through numerical calculation using the measured magnetic properties. © 2001 Elsevier Science B.V. All rights reserved.

Structure-based drug design studies on a series of aldolase inhibitors

Human African trypanosomiasis, also known as sleeping sickness, is a major cause of death in Africa, and for which there are no safe and effective treatments available. The enzyme aldolase from Trypanosoma brucei is an attractive, validated target for drug development. A series of alkyl‑glycolamido and alkyl-monoglycolate derivatives was studied employing a combination of drug design approaches. Three-dimensional quantitative structure-activity relationships (3D QSAR) models were generated using the comparative molecular field analysis (CoMFA). Significant results were obtained for the best QSAR model (r2 = 0.95, non-cross-validated correlation coefficient, and q2 = 0.80, cross-validated correlation coefficient), indicating its predictive ability for untested compounds. The model was then used to predict values of the dependent variables (pKi) of an external test set,the predicted values were in good agreement with the experimental results. The integration of 3D QSAR, molecular docking and molecular dynamics simulations provided further insight into the structural basis for selective inhibition of the target enzyme.

First Ramsey-type mass measurements with ISOLTRAP and design studies of the new PENTATRAP project

Der Einsatz von Penningfallen in der Massenspektrometrie hat zu einem einmaligen Genauigkeitssprung geführt. Dadurch wurden Massenwerte verschiedenster Atome zu wichtigen Eingangsparametern bei immer mehr physikalischen Fragestellungen. Die Massenspektrometrie mit Hilfe von Penningfallen basiert auf der Bestimmung der freien Zyklotronfrequenz eines Ions in einem homogenen Magnetfeld νc=qB/(2πm). Sie wird mit Flugzeitmethode (TOF-ICR) bestimmt, wobei eine relative Massenungenauigkeit δm/m von wenigen 10^-9 bei Nukliden mit Lebensdauern von <500 ms erreicht wird. Dies wurde durch die im Rahmen dieser Arbeit erstmals in der Penningfallen-Massenspektrometrie eingesetzten Ramsey-Methode möglich. Dabei werden zeitlich separierte, oszillierenden Feldern zur resonanten Ionenanregung genutzt, um die Frequenzmessung durch die Flugzeitmethode zu verbessern. Damit wurden am Penningfallenmassenspektrometer ISOLTRAP an ISOLDE/CERN die Massen der Nuklide 26,27Al und 38,39Ca bestimmt. Alle Massen wurden in die „Atomic Mass Evaluation“ eingebettet. Die Massenwerte von 26Al und 38Ca dienten insbesondere zu Tests des Standardmodells. Um mit Massenwerten fundamentale Symmetrien oder die Quantenelektrodynamik (QED) in extremen Feldern zu testen wurde ein neues Penningfallenprojekt (PENTATRAP) für hochpräzise Massenmessungen an hochgeladenen Ionen konzipiert. In dieser Doktorarbeit wurde vornehmlich die Entwicklung der Penningfallen betrieben. Eine Neuerung bei Penningfallenexperimenten ist dabei die permanente Beobachtung des Magnetfeldes B und seiner zeitlichen Fluktuationen durch so genannte „Monitorfallen“.

Methods of energy recovery in the iron and steel industry: evalution of new possibilities and design studies for slab cooling

DUE TO COPYRIGHT RESTRICTIONS ONLY AVAILABLE FOR CONSULTATION AT ASTON UNIVERSITY LIBRARY WITH PRIOR ARRANGEMENT

The Design with Intent Method: a design tool for influencing user behaviour

Using product and system design to influence user behaviour offers potential for improving performance and reducing user error, yet little guidance is available at the concept generation stage for design teams briefed with influencing user behaviour. This article presents the Design with Intent Method, an innovation tool for designers working in this area, illustrated via application to an everyday human–technology interaction problem: reducing the likelihood of a customer leaving his or her card in an automatic teller machine. The example application results in a range of feasible design concepts which are comparable to existing developments in ATM design, demonstrating that the method has potential for development and application as part of a user-centred design process.

Making the user more efficient: Design for sustainable behaviour

User behaviour is a significant determinant of a product’s environmental impact; while engineering advances permit increased efficiency of product operation, the user’s decisions and habits ultimately have a major effect on the energy or other resources used by the product. There is thus a need to change users’ behaviour. A range of design techniques developed in diverse contexts suggest opportunities for engineers, designers and other stakeholders working in the field of sustainable innovation to affect users’ behaviour at the point of interaction with the product or system, in effect ‘making the user more efficient’. Approaches to changing users’ behaviour from a number of fields are reviewed and discussed, including: strategic design of affordances and behaviour-shaping constraints to control or affect energyor other resource-using interactions; the use of different kinds of feedback and persuasive technology techniques to encourage or guide users to reduce their environmental impact; and context-based systems which use feedback to adjust their behaviour to run at optimum efficiency and reduce the opportunity for user-affected inefficiency. Example implementations in the sustainable engineering and ecodesign field are suggested and discussed.

Exploring design patterns for sustainable behaviour

Products and services explicitly intended to influence users’ behaviour are increasingly being proposed to reduce environmental impact and for other areas of social benefit. Designing such interventions often involves adopting and adapting principles from other contexts where behaviour change has been studied. The ‘design pattern’ form, used in software engineering and HCI, and originally developed in architecture, offers benefits for this transposition process. This article introduces the Design with Intent toolkit, an idea generation method using a design pattern form to help designers address sustainable behaviour problems. The article also reports on exploratory workshops in which participants used the toolkit to generate concepts for redesigning everyday products—kettles, curtains, printers and bathroom sinks/taps—to reduce the environmental impact of use. The concepts are discussed, along with observations of how the toolkit was used by participants, suggesting usability improvements to incorporate in future versions.

Designing motivation or motivating design? Exploring Service Design, motivation and behavioural change

Motivation researcher Edward Deci has suggested that if we want behavioural change to be sustainable, we have to move past thinking of motivation as something that we ‘do’ to other people and see it rather as something that we as Service Designers can enable service users to ‘do’ by themselves. In this article, Fergus Bisset explores the ways in which Service Designers can create more motivating services. Dan Lockton then looks at where motivating behaviour via Service Design often starts, with the basic ‘pinball’ and ‘shortcut’ approaches. We conclude by proposing that if services are to be sustainable in the long term, we as Service Designers need to strive to accommodate humans' differing levels of motivation and encourage and support service users' sense of autonomy within the services we design.