Die hamburgischen Bürgermeister Kirchenpauer, Petersen, Versmann : Beiträge zur deutschen Geschichte des neunzehnten Jahrhunderts /

Bibliographical footnotes.

Ueber ein Herbarium prussicum des Georg Andreas Helwing aus dem Jahre 1717

von Dr. Conwentz

Verzeichniss einer ausgewählten Sammlung von original-Oelgemälden aus dem nachlass des Stadtraths und Buchhändlers Georg Andreas Reimer zu Berlin, den 27 März 1843.

Mode of access: Internet.

Georg Andreas Will's Nürnbergisches Gelehrten-Lexicon, oder, Beschreibung aller nürnbergischen Gelehrten ... / fünfterachter Theil oder erster-vierter Supplementband.

Incorporates material collected by Will, including the letters A and B printed by him in 1783.

Ms. lat. oct. 47 - Responsionale secundum usum ecclesiae S. Bartholomaei Francfordensis

Vorbesitzer: Johannes Latomus; Andreas Weber; Georg Gambach; Bernhard Diell

Methane and stable isotope record of ice core EDML from Dronning Maud Land, Antarctica

Precise knowledge of the phase relationship between climate changes in the two hemispheres is a key for understanding the Earth's climate dynamics. For the last glacial period, ice core studies have revealed strong coupling of the largest millennial-scale warm events in Antarctica with the longest Dansgaard-Oeschger events in Greenland through the Atlantic meridional overturning circulation. It has been unclear, however, whether the shorter Dansgaard-Oeschger events have counterparts in the shorter and less prominent Antarctic temperature variations, and whether these events are linked by the same mechanism. Here we present a glacial climate record derived from an ice core from Dronning Maud Land, Antarctica, which represents South Atlantic climate at a resolution comparable with the Greenland ice core records. After methane synchronization with an ice core from North Greenland, the oxygen isotope record from the Dronning Maud Land ice core shows a one-to-one coupling between all Antarctic warm events and Greenland Dansgaard-Oeschger events by the bipolar seesaw. The amplitude of the Antarctic warm events is found to be linearly dependent on the duration of the concurrent stadial in the North, suggesting that they all result from a similar reduction in the meridional overturning circulation.

TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5

Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) and agonistic anti-DR4/TRAIL-R1 and anti-DR5/TRAIL-R2 antibodies are currently under clinical investigation for treatment of different malignancies. TRAIL activates DR4 and DR5 and thereby triggers apoptotic and non-apoptotic signaling pathways, but possible different roles of DR4 or DR5 in these responses has poorly been addressed so far. In the present work, we analyzed cell viability, DISC formation as well as IL-8 and NF-kappaB activation side by side in responses to TRAIL and agonistic antibodies against DR4 (mapatumumab) and against DR5 (lexatumumab) in pancreatic ductal adenocarcinoma cells. We found that all three reagents are able to activate cell death and pro-inflammatory signaling. Death-inducing signaling complex (DISC) analysis revealed that mapatumumab and lexatumumab induce formation of homocomplexes of either DR4 or DR5, whereas TRAIL additionally stimulated the formation of heterocomplexes of both receptors. Notably, blocking of receptors using DR4- and DR5-specific Fab fragments indicated that TRAIL exerted its function predominantly via DR4. Interestingly, inhibition of PKC by Goe6983 enabled DR5 to trigger apoptotic signaling in response to TRAIL and also strongly enhanced lexatumumab-mediated cell death. Our results suggest the existence of mechanisms that silence DR5 for TRAIL- but not for agonistic-antibody treatment.