Trouble shooting electronic equipment; an empirical approach to the identification of certain requirements of a maintenance occupation. A report of an aspect of a research project under Air Force Contract no.33 (038)-13236, Project no. 507-007-0001,

Bibliography: p. 100-102.

An evaluation of the trainer-tester and punchboard tutor as electronics trouble-shooting training aids,

Mode of access: Internet.

Mechanism of tocopherol transfer by human α-tocopherol transfer protein (α-hTTP)

Vitamin E is a well known fat soluble chain breaking antioxidant. It is a general tenn used to describe a family of eight stereoisomers of tocopherols. Selective retention of a-tocopherol in the human circulation system is regulated by the a -Tocopherol Transfer Protein (a-TIP). Using a fluorescently labelled a-tocopherol (NBD-a-Toc) synthesized in our laboratory, a fluorescence resonance energy transfer (FRET) assay was developed to monitor the kinetics of ligand transfer by a-hTTP in lipid vesicles. Preliminary results implied that NBD-a-Toe simply diffused from 6-His-a-hTTP to acceptor membranes since the kinetics of transfer were not responsive to a variety of conditions tested. After a series of trouble shooting experiments, we identified a minor contaminant, E coli. outer membrane porin F (OmpF) that co-purified with 6-His-a-hTTP from the metal affinity column as the source of the problem. In order to completely avoid OmpF contamination, a GST -a-hTTP fusion protein was purified from a glutathione agarose column followed by an on-column thrombin digestion to remove the GST tag. We then demonstrated that a-hTTP utilizes a collisional mechanism to deliver its ligand. Furthennore, a higher rate of a-tocopherol transfer to small unilamellar vesicles (SUV s) versus large unilamellar vesicles (LUV s) indicated that transfer is sensitive to membrane curvature. These findings suggest that ahTTP mediated a-Toc transfer is dominated by the hydrophobic nature of a-hTTP and the packing density of phospholipid head groups within acceptor membranes. Based on the calculated free energy change (dG) when a protein is transferred from water to the lipid bilayer, a model was generated to predict the orientation of a-hTTP when it interacts with lipid membranes. Guided by this model, several hydrophobic residues expected to penetrate deeply into the bilayer hydrophobic core, were mutated to either aspartate or alanine. Utilizing dual polarization interferometry and size exclusion vesicle binding assays, we identified the key residues for membrane binding to be F 165, F 169 and 1202. In addition, the rates of ligand transfer of the u-TTP mutants were directly correlated to their membrane binding capabilities, indicating that membrane binding was likely the rate limiting step in u-TTP mediated transfer of u-Toc. The propensity of u-TTP for highly curved membrane provides a connection to its colocalization with u-Toc in late endosomes.

Water Quality Variation, its Influence on Drinking Water Treatment and Remedial Measures - A Case Study of Peechi reservoir, Thrissur, Kerala

The Kerala Water Authority requested the School of Environmental Studies to carry out investigations on the mechanism of sporadic mobilization of iron and odour in the raw water drawn to the drinking water treatment plant. The currently used treatment process failed to remove iron completely. This led to problems in the filter and complaints of taste and colour due to iron in the finished water. The sporadic nature of the problem itself made the trouble shooting difficult. The problem was looked in from three points of view. 1. Influence of environmental (climatic) conditions on the dynamics of the relevant basin of the reservoir. 2. Influence of the physical dynamics on the physico — chemical quality of water. 3. Identification of cost-effective treatment processes to suit the existing plant. Since the problem emerged only during the post- monsoon to pre-monsoon months, a related problem was investigated, namely, influence of anions on the oxidation of Fe(II) in natural waters by air. This is presented in Part II of the dissertation.

Using Problem Steps Recorder on Windows 7

Problem Steps Recorder is a standard piece of software on Windows 7 computers, which allows you to record a sequence of actions on your computer, along with screenshots. It can help ServiceLine diagnose any problems that you might be experiencing.

Ensino-aprendizagem das equações algébricas através da resolução de problemas

Pós-graduação em Educação Matemática - IGCE

Performatividade homoerótica em práticas discursivas docentes

Práticas discursivas sobre o homoerotismo e docência são objetos de desejo nesta Tese produzida a partir do trabalho com narrativas docentes. Ao adotar-se uma investida em jogos discursivos subversivos que desmargeiam os centros e povoam as periferias na produção epistemológica, adveio perscrutar sobre docência e diferença e procurar em narrativas a produção da performatividade homoerótica na experiência do ensino superior. No encalce deste intento, rastros levaram ao pós-estruturalismo como teorização da diferença na busca de composições em devires e conduziram à produção de uma escritura que ocorre em uma conjunção epistemológica que considera a sua fragmentação, inconstância, deslizamentos e interpelamentos arquitetados enquanto tirocínios discursivos, orientados, e por vezes desorientados, por entendimentos deleuzianos e foucaultianos. Nas linhas de fuga dessas orientações se investe em uma experiência de escritura cartográfica multiplicadora de acontecimentos em jogos intensos de processualidades e experimentações para produzir uma poética da escrita com invenções, contos, poesias, devaneios e divagações. Atravessa o estudo a compreensão da experiência homoerótica na docência enquanto lugar da abjeção virtualizado e atualizado num continuum de problematizações e recolocações, achados e criações. A experiência homoerótica na docência opera, portanto, como um espaço móvel, provocativo, perturbador, instável e fronteiriço, atravessado por práticas discursivas que lhe imprimem governamento, performatividade e desproblematização, porém, lugar de onde emerge a possibilidade de dissensos. Por isso, quando o contrassenso da significação se instala no sítio da experiência docente, as performances são deslocadas e passam a operar de forma produtiva forjando sujeitos fronteiras, entre/através, na travessia de dois lugares simbólicos – o homoerotismo e a docência.

Applying qualitative reasoning to finance

Qualitative reasoning has traditionally been applied in the domain of physical systems, where there are well established and understood laws governing the behaviour of each `component' in the system. Such application has shown that it is possible to produce models which can be used for explaining and predicting the behaviour of physical phenomena and also trouble-shooting. The principles underlying the theory ensure that the models are robust and exhibit consistent behaviour under all conditions. This research examines the validity of applying the theory in the financial domain where such laws may not exist or if they do, may not be universally applicable. In particular, it investigates how far these principles and techniques may be applied in the construction of financial analysis models. Because of the inherent differences in the nature of these two domains, it is argued that a different qualitative value system ought to be employed. The dissertation enlarges on the constraints this places on model descriptions and the effect it may have on the power and usefulness of the resulting models. It also describes the implementation of a system that investigates the implications of applying this theory by way of testing it on situations drawn from both text-books and published financial information.

Does anticipation of back pain predispose to back trouble?

Limb movement imparts a perturbation to the body. The impact of that perturbation is limited via anticipatory postural adjustments. The strategy by which the CNS controls anticipatory postural adjustments of the trunk muscles during limb movement is altered during acute back pain and in people with recurrent back pain, even when they are pain free. The altered postural strategy probably serves to protect the spine in the short term, but it is associated with a cost and is thought to predispose spinal structures to injury in the long term. It is not known why this protective strategy might occur even when people are pain free, but one possibility is that it is caused by the anticipation of back pain. In eight healthy subjects, recordings of intramuscular EMG were made from the trunk muscles during single and repetitive arm movements. Anticipation of experimental back pain and anticipation of experimental elbow pain were elicited by the threat of painful cutaneous stimulation. There was no effect of anticipated experimental elbow pain on postural adjustments. During anticipated experimental back pain, for single arm movements there was delayed activation of the deep trunk muscles and augmentation of at least one superficial trunk muscle. For repetitive arm movements, there was decreased activity and a shift from biphasic to monophasic activation of the deep trunk muscles and increased activity of superficial trunk muscles during anticipation of back pain. In both instances, the changes were consistent with adoption of an altered strategy for postural control and were similar to those observed in patients with recurrent back pain. We conclude that anticipation of experimental back pain evokes a protective postural strategy that stiffens the spine. This protective strategy is associated with compressive cost and is thought to predispose to spinal injury if maintained long term. © Guarantors of Brain 2004; all rights reserved

Curadoria em artes performativas: o ciclo temático gender trouble - performance, performatividade e política de género no Teatro Municipal Maria Matos

O presente relatório pretende ilustrar os resultados do estágio na área de programação artística desenvolvido no Teatro Municipal Maria Matos, em Lisboa. Apresenta um enquadramento desta organização e uma reflexão crítica e teórica sobre o conceito de curadoria de artes performativas, especificamente, no que diz respeito ás práticas para estruturar um programa temático no teatro municipal enquanto centro de exibição, produção e divulgação das artes performativas. O relatório articula três partes. Na primeira parte, aborda-­‐se uma aproximação institucional e a descrição das tarefas da área de programação no Teatro Maria Matos. Na segunda parte, apresentam-­‐se conceptualmente as questões da programação temática Gender Trouble -­‐ performance, performatividade e política de género, as relações com a arte contemporânea e a história de arte. E, finalmente, na terceira apresentam-­‐se algumas observações sobre a estrutura de programação e produção de Gender Trouble, no âmbito da rede internacional House on Fire, em colaboração com parceiros internacionais, tornando-­‐se esta linha programática um convite para uma reflexão sobre a genealogia do conceito “performatividade de género” que espelha reflexões teóricas e práticas artísticas, académicas e ativistas.

Programme de remédiation cognitive pour patients présentant une schizophrénie ou un trouble associé (Recos) : résultats préliminaires [Cognitive remediation program for individuals living with schizophrenia (Recos): preliminary results].

BACKGROUND: Nowadays, cognitive remediation is widely accepted as an effective treatment for patients with schizophrenia. In French-speaking countries, techniques used in cognitive remediation for patients with schizophrenia have been applied from those used for patients with cerebral injury. As cognitive impairment is a core feature of schizophrenia, the Département de psychiatrie du CHUV in Lausanne (DP-CHUV) intended to develop a cognitive remediation program for patients with a schizophrenia spectrum disease (Recos-Vianin, 2007). Numerous studies show that the specific cognitive deficits greatly differ from one patient to another. Consequently, Recos aims at providing individualized cognitive remediation therapy. In this feasibility trial, we measured the benefits of this individualized therapy for patients with schizophrenia. Before treatment, the patients were evaluated with a large battery of cognitive tests in order to determine which of the five specific training modules - Verbal memory, visuospatial memory and attention, working memory, selective attention, reasoning - could provide the best benefit depending on their deficit. OBJECTIVES: The study was designed to evaluate the benefits of the Recos program by comparing cognitive functioning before and after treatment. METHOD: Twenty-eight patients with schizophrenia spectrum disorders (schizophrenia [n=18], schizoaffective disorder [n=5], schizotypal disorder [n=4], schizophreniform disorder [n=1], DSM-IV-TR) participated in between one and three of the cognitive modules. The choice of the training module was based on the results of the cognitive tests obtained during the first evaluation. The patients participated in 20 training sessions per module (one session per week). At the end of the training period, the cognitive functioning of each patient was reevaluated by using the same neuropsychological battery. RESULTS: The results showed a greater improvement in the cognitive functions, which were specifically trained, compared to the cognitive functions, which were not trained. However, an improvement was also observed in both types of cognitive functions, suggesting an indirect cognitive gain. CONCLUSION: In our view, the great heterogeneity of the observed cognitive deficits in schizophrenia necessitates a detailed neuropsychological investigation as well as an individualized cognitive remediation therapy. These preliminary results need to be confirmed with a more extended sample of patients.