At a court of admiralty held at Boston ... the 22d day of 1704 was condemned the briggantine Charles whereof John Quelch was late commander ... , 1704

Attestation regarding the trial of Quelch and other defendants, who were convicted of piracy. Signed: John Valentine, registrar.

Notes on cases in Boston, 1784-1790

Notes on various cases, including cases of burglary, debt, fraud, libel, receiving stolen goods, and one case of attempted murder of an infant by his mother.

Efficacy and Safety of Natalizumab in Crohn’s Disease Patients Treated at 6 Boston Academic Hospitals

BACKGROUND: Despite trials demonstrating its efficacy, many physicians harbor concerns regarding the use of natalizumab in the treatment of patients with refractory Crohn's disease (CD). The purpose of this study was to perform a descriptive analysis of a series of CD patients not currently enrolled in a clinical trial. METHODS: A retrospective case review of patients treated with natalizumab at 6 sites in Massachusetts: Boston Medical Center, Beth Israel Deaconess Medical Center, Brigham & Women's Hospital, Lahey Clinic, Massachusetts General Hospital, and UMass Medical Center. RESULTS: Data on 69 CD patients on natalizumab were collected. At the start of treatment, patients' disease duration was 12 years. A high proportion of patients were women (68%), presented with perianal disease (65%) and upper gastrointestinal tract involvement (14%). Prior nonbiologic therapies were steroids (96%), thiopurines (94%), antibiotics (74%), methotrexate (58%), and at least two anti-tumor necrosis factor agent failures (81%). Sixty-nine percent (44 of 64 patients) with available medical evaluation had a partial or complete clinical response. Loss of response was 13% after an average of 1 year of treatment. Adverse events were infusion reactions, headaches, fever, and infections. No case of progressive multifocal leukoencephalopathy was observed. CONCLUSIONS: In our clinical experience outside the context of a clinical trial, natalizumab is largely reserved for CD patients with extensive ileocolonic disease who have failed conventional immunosuppressants and of at least 2 anti-tumor necrosis factor agents. This drug is, however, well tolerated and offers significant clinical improvement for more than a year in one-third of these difficult-to-treat CD patients.

Notes on cases in Boston and Springfield, 1790-1793

Notes by unknown author on cases of land rights, debt, and theft.

Proposed Parks and Parkways, Boston, Massachusetts, 1876 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Proposed parks and parkways. It was published by Park Dept., City of Boston in 1876. Scale [ca. 1:25,000]. Covers also parts of adjacent towns and cities, including all of Cambridge, Somerville, and Brookline.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001) coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, proposed parks, parkways, and roads, public grounds, sewer lines, railroad stations, radial distances from City Hall, and more.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Boston, Massachusetts, 1797 (Image 4 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: An accurate plan of the town of Boston and its vicinity : exhibiting a ground plan of all the streets, lanes, alleys, wharves, and public buildings in Boston, with the names and description thereof, likewise all the flats and channels between Boston and Charlestown, Cambridge, Roxbury & Dorchester with the two bridges and causeway, and the boundary lines beween Boston and the above mentioned towns from ... by Osgood Carleton ; I. Norman, sc. It was published and sold by Osgood Carleton in 1797. Scale [ca. 1:4,170]. This layer is image 4 of 4 total images, representing the southeast portion of the four sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, selected public buildings, city ward boundaries, wharves, and more. Relief shown by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Boston, Massachusetts, 1797 (Image 3 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: An accurate plan of the town of Boston and its vicinity : exhibiting a ground plan of all the streets, lanes, alleys, wharves, and public buildings in Boston, with the names and description thereof, likewise all the flats and channels between Boston and Charlestown, Cambridge, Roxbury & Dorchester with the two bridges and causeway, and the boundary lines beween Boston and the above mentioned towns from ... by Osgood Carleton ; I. Norman, sc. It was published and sold by Osgood Carleton in 1797. Scale [ca. 1:4,170]. This layer is image 3 of 4 total images, representing the southwest portion of the four sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, selected public buildings, city ward boundaries, wharves, and more. Relief shown by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Boston, Massachusetts, 1797 (Image 1 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: An accurate plan of the town of Boston and its vicinity : exhibiting a ground plan of all the streets, lanes, alleys, wharves, and public buildings in Boston, with the names and description thereof, likewise all the flats and channels between Boston and Charlestown, Cambridge, Roxbury & Dorchester with the two bridges and causeway, and the boundary lines beween Boston and the above mentioned towns from ... by Osgood Carleton ; I. Norman, sc. It was published and sold by Osgood Carleton in 1797. Scale [ca. 1:4,170]. This layer is image 1 of 4 total images, representing the northwest portion of the four sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, selected public buildings, city ward boundaries, wharves, and more. Relief shown by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Boston, Massachusetts Region, Digital Elevation Model with Bathymetry

This raster layer represents surface elevation and bathymetry data for the Boston Region, Massachusetts. It was created by merging portions of MassGIS Digital Elevation Model 1:5,000 (2005) data with NOAA Estuarine Bathymetric Digital Elevation Models (30 m.) (1998). DEM data was derived from the digital terrain models that were produced as part of the MassGIS 1:5,000 Black and White Digital Orthophoto imagery project. Cellsize is 5 meters by 5 meters. Each cell has a floating point value, in meters, which represents its elevation above or below sea level.

Boston, Massachusetts, 1797 (Image 2 of 4) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: An accurate plan of the town of Boston and its vicinity : exhibiting a ground plan of all the streets, lanes, alleys, wharves, and public buildings in Boston, with the names and description thereof, likewise all the flats and channels between Boston and Charlestown, Cambridge, Roxbury & Dorchester with the two bridges and causeway, and the boundary lines beween Boston and the above mentioned towns from ... by Osgood Carleton ; I. Norman, sc. It was published and sold by Osgood Carleton in 1797. Scale [ca. 1:4,170]. This layer is image 2 of 4 total images, representing the northeast portion of the four sheet source map. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, selected public buildings, city ward boundaries, wharves, and more. Relief shown by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Boston Harbor Including Boston and Surroundings, Massachusetts, Nautical Chart, 1775 (Image 1 of 2) (Raster Image)

This layer is a georeferenced raster image of the historic nautical chart entitled: A chart of the harbour of Boston (sheet originally published in 1775). The map is [sheet 21] from the Atlantic Neptune atlas Vol. 3 : Charts of the coast and harbors of New England, from surveys taken by Samuel Holland and published by J.F.W. Des Barres, 1781. Scale [ca. 1:25,000]. This layer is image 1 of 2 total images of the two sheet source map, representing the western portion of the map. Covers Boston and surrounding towns and Boston Harbor, Massachusetts. The image is georeferenced to the surface of the earth and fit to the 'World Mercator' (WGS 84) projected coordinate system. All map collar information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows coastal features such as harbors, inlets, rocks, channels, points, coves, shoals, islands, and more. Includes also selected land features such as cities and towns, roads, fortifications, and buildings. Relief is shown by hachures; depths by soundings and shading. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection. The entire Atlantic Neptune atlas Vol. 3 : Charts of the coast and harbors of New England has been scanned and georeferenced as part of this selection.

Boston Harbor Including Boston and Surroundings, Massachusetts, Nautical Chart, 1775 (Image 2 of 2) (Raster Image)

This layer is a georeferenced raster image of the historic nautical chart entitled: A chart of the harbour of Boston (sheet originally published in 1775). The map is [sheet 22] from the Atlantic Neptune atlas Vol. 3 : Charts of the coast and harbors of New England, from surveys taken by Samuel Holland and published by J.F.W. Des Barres, 1781. Scale [ca. 1:25,000]. This layer is image 2 of 2 total images of the two sheet source map, representing the eastern portion of the map. Covers portion of Boston Harbor, Massachusetts and surrounding towns. The image is georeferenced to the surface of the earth and fit to the 'World Mercator' (WGS 84) projected coordinate system. All map collar information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows coastal features such as harbors, inlets, rocks, channels, points, coves, shoals, islands, and more. Includes also selected land features such as cities and towns, roads, fortifications, and buildings. Relief is shown by hachures; depths by soundings and shading. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection. The entire Atlantic Neptune atlas Vol. 3 : Charts of the coast and harbors of New England has been scanned and georeferenced as part of this selection.

Boston, Massachusetts, 1852 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the city of Boston and immediate neighborhood : from original surveys by H. McIntyre. It was published by H. McIntyre in 1852. Scale [1:5,400]. Covers also portions of Cambridge and Somerville, Massachusetts.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, selected public buildings, schools, churches, cemeteries, industry locations (e.g. mills, factories, mines, etc.), selected private buildings with names of property owners, town boundaries, and more. Includes also 56 views of buildings.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

West Roxbury, Boston, Massachusetts, ca. 1875 (Raster Image)

This layer is a georeferenced raster image of the historic manuscript, paper map entitled: Map of West Roxbury : from official records, private plans and actual surveys by H. W. Hopkins, C.E. It was created ca. 1875. Scale [1:4,800].The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads, drainage, selected public buildings, cemeteries, industry locations (e.g. mills, factories, mines, etc.), selected private buildings with names of property owners, property lot boundaries, town boundaries, city wards, and more. Includes also pencil manuscript annotations added at later date.This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.

Boston Harbor, Massachusetts, 1780 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte particulière du havre de Boston, réduite de la carte anglaise de J.E.S. Des Barres, écuyer ; la déclinaison de l'aiguille aimantée à été observée de 6d. 4'. N.O. en 8bre. 1778, par M. le marquis de Chabert qui à sussi déterminé à terre la latitude de divers points auxquels cette carte à été assujetie. It was published by Dépôt des cartes et plans de la marine, 1780. Scale [ca. 1:33,000]. Covers Boston Harbor and adjacent lands. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Massachusetts State Plane Coordinate System, Mainland Zone (in Feet) (Fipszone 2001). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows coastal features such as rocks, flats, channels, points, coves, islands, and more. Depths are shown by soundings and shading. It also shows land features such as roads, settlements, drainage, and more. Relief is shown by hachures. This layer is part of a selection of digitally scanned and georeferenced historic maps of Massachusetts from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates (1755-1922), scales, and purposes. The digitized selection includes maps of: the state, Massachusetts counties, town surveys, coastal features, real property, parks, cemeteries, railroads, roads, public works projects, etc.