The law of unfair business competition, including chapters on trade secrets and confidential business relations; unfair interference with contracts; libel and slander of articles of merchandise, trade names, and business credit and reputation,

Mode of access: Internet.

Report of the case of Timothy Upham against Hill & Barton, publishers of the New-Hampshire patriot, for alleged libels, at the Court of common pleas, Rockingham county, March and October terms, 1830.

Mode of access: Internet.

A treatise on the law of libel and the liberty of the press; showing the origin, use, and abuse of the law of libel: with copious notes and references to authorities in Great Britain and the United States: as applicable to individuals and to political and ecclesiastical bodies and principles.

Microfilm. Ann Arbor, Mich. University Microfilms (n.d.) (American Culture Series, Reel 238.4)

The triumph of virtue : the trial of Miss Mary Ann Tocker, who plead her own cause, for an alleged libel on R. Gurney, Jun. ... to which is prefixed a letter to Miss Tocker, and to which is added an address to jury-men on their duties as jurors, and especially on trials for criminal libel /

"From the third New-York edition."

The Littlejohn libel suit : the case of De Witt C. Littlejohn against Horace Greeley : tried at the Oswego term of the Supreme Court of the State of New York, at Pulaski, Sept. 10-13, 1861 ... /

Mode of access: Internet.

Review, of the report of the case of the Commonwealth versus David Lee Child, for publishing in the Massachusetts Journal a libel on the honorable John Keyes.

At head of title: (From the Concord (Middlesex) Gazette.).

Surveillance and slander : Eleanor Dark in the 1940s and 1950s

Examines the effects of national surveillance and local right-wing intimidation on the literary works of author Eleanor Dark during the 1940s and 1950s in Australia. Reason Dark was subjected to national surveillance and right-wing intimidation; Relationship of Dark with local and national security forces; Accusations against the Dark family; Censorship faced by writers.

Manufacturing and use of human placenta-derived mesenchymal stromal cells for phase I clinical trials: Establishment and evaluation of a protocol

Background/Aim. Mesenchymal stromal cells (MSCs) have been utilised in many clinical trials as an experimental treatment in numerous clinical settings. Bone marrow remains the traditional source tissue for MSCs but is relatively hard to access in large volumes. Alternatively, MSCs may be derived from other tissues including the placenta and adipose tissue. In an initial study no obvious differences in parameters such as cell surface phenotype, chemokine receptor display, mesodermal differentiation capacity or immunosuppressive ability, were detected when we compared human marrow derived- MSCs to human placenta-derived MSCs. The aim of this study was to establish and evaluate a protocol and related processes for preparation placenta-derived MSCs for early phase clinical trials. Methods. A full-term placenta was taken after delivery of the baby as a source of MSCs. Isolation, seeding, incubation, cryopreservation of human placentaderived MSCs and used production release criteria were in accordance with the complex regulatory requirements applicable to Code of Good Manufacturing Practice manufacturing of ex vivo expanded cells. Results. We established and evaluated instructions for MSCs preparation protocol and gave an overview of the three clinical areas application. In the first trial, MSCs were co-transplanted iv to patient receiving an allogeneic cord blood transplant as therapy for treatmentrefractory acute myeloid leukemia. In the second trial, MSCs were administered iv in the treatment of idiopathic pulmonary fibrosis and without serious adverse effects. In the third trial, MSCs were injected directly into the site of tendon damage using ultrasound guidance in the treatment of chronic refractory tendinopathy. Conclusion. Clinical trials using both allogeneic and autologous cells demonstrated MSCs to be safe. A described protocol for human placenta-derived MSCs is appropriate for use in a clinical setting, relatively inexpensive and can be relatively easily adjusted to a different set of regulatory requirements, as applicable to early phase clinical trials.

Is adjuvant chemotherapy of benefit for postmenopausal women who receive endocrine treatment for highly endocrine-responsive, node-positive breast cancer? International Breast Cancer Study Group Trials VII and 12-93

To compare the efficacy of chemoendocrine treatment with that of endocrine treatment (ET) alone for postmenopausal women with highly endocrine responsive breast cancer. In the International Breast Cancer Study Group (IBCSG) Trials VII and 12-93, postmenopausal women with node-positive, estrogen receptor (ER)-positive or ER-negative, operable breast cancer were randomized to receive either chemotherapy or endocrine therapy or combined chemoendocrine treatment. Results were analyzed overall in the cohort of 893 patients with endocrine-responsive disease, and according to prospectively defined categories of ER, age and nodal status. STEPP analyses assessed chemotherapy effect. The median follow-up was 13 years. Adding chemotherapy reduced the relative risk of a disease-free survival event by 19% (P = 0.02) compared with ET alone. STEPP analyses showed little effect of chemotherapy for tumors with high levels of ER expression (P = 0.07), or for the cohort with one positive node (P = 0.03). Chemotherapy significantly improves disease-free survival for postmenopausal women with endocrine-responsive breast cancer, but the magnitude of the effect is substantially attenuated if ER levels are high.

Systematic reviews and meta-analyses of randomized trials: principles and pitfalls

Systematic reviews and meta-analyses allow for a more transparent and objective appraisal of the evidence. They may decrease the number of false-negative results and prevent delays in the introduction of effective interventions into clinical practice. However, as for any other tool, their misuse can result in severely misleading results. In this article, we discuss the main steps that should be taken when conducting systematic reviews and meta-analyses, namely the preparation of a review protocol, identification of eligible trials, and data extraction, pooling of treatment effects across trials, investigation of potential reasons for differences in treatment effects across trials, and complete reporting of the review methods and findings. We also discuss common pitfalls that should be avoided, including the use of quality assessment tools to derive summary quality scores, pooling of data across trials as if they belonged to a single large trial, and inappropriate uses of meta-regression that could result in misleading estimates of treatment effects because of regression to the mean or the ecological fallacy. If conducted and reported properly, systematic reviews and meta-analyses will increase our understanding of the strengths and weaknesses of the available evidence, which may eventually facilitate clinical decision making.

Outcome-based adaptive randomization for binary data in clinical trials---Compare and contrast

Monte Carlo simulation has been conducted to investigate parameter estimation and hypothesis testing in some well known adaptive randomization procedures. The four urn models studied are Randomized Play-the-Winner (RPW), Randomized Pôlya Urn (RPU), Birth and Death Urn with Immigration (BDUI), and Drop-the-Loses Urn (DL). Two sequential estimation methods, the sequential maximum likelihood estimation (SMLE) and the doubly adaptive biased coin design (DABC), are simulated at three optimal allocation targets that minimize the expected number of failures under the assumption of constant variance of simple difference (RSIHR), relative risk (ORR), and odds ratio (OOR) respectively. Log likelihood ratio test and three Wald-type tests (simple difference, log of relative risk, log of odds ratio) are compared in different adaptive procedures. ^ Simulation results indicates that although RPW is slightly better in assigning more patients to the superior treatment, the DL method is considerably less variable and the test statistics have better normality. When compared with SMLE, DABC has slightly higher overall response rate with lower variance, but has larger bias and variance in parameter estimation. Additionally, the test statistics in SMLE have better normality and lower type I error rate, and the power of hypothesis testing is more comparable with the equal randomization. Usually, RSIHR has the highest power among the 3 optimal allocation ratios. However, the ORR allocation has better power and lower type I error rate when the log of relative risk is the test statistics. The number of expected failures in ORR is smaller than RSIHR. It is also shown that the simple difference of response rates has the worst normality among all 4 test statistics. The power of hypothesis test is always inflated when simple difference is used. On the other hand, the normality of the log likelihood ratio test statistics is robust against the change of adaptive randomization procedures. ^

Oat Variety Trials, 2010 and 2011

Oat is the major spring-sown, small grain crop in Iowa. Spring-sown small grains can be used for grain and straw production, as a companion crop to establish hay and pastures, or as a source of early-season forage as hay or haylage. Because small grains generally mature before the end of July, a forage legume, cover crop, or green manure crop can follow oats, or animal manure can be spread on the field in which oats were grown.

Records of cases before the Mayor's Court of Albany, 1786-1796

Contains a summary of cases before the court beginning with the litigants and the damages sought, the legal action, names of counsel, actions taken, and the final disposition of the case. Most actions taken relate to debt, assault and battery, and slander and libel. At the back of the manuscript are "an account of law books by me purchased in the year 1784 & 1785" [p. 120], and"a list miscellanious books bought in the year 1784 & 1785" [p. 132].

Chemoprevention clinical trials : problems and solutions /

"November 1984."

Discussions of the law of libels as at present received, in which its authenticity is examined; with incidental observations on the legal effects of precedent and authority.

Mode of access: Internet.