Statistiques 2004-2005 et 2005-2006 des bibliothèques universitaires et de recherche au Canada

Commentaire de M. Timothy Mark Executive Director / Directeur général Canadian Association of Research Libraries / Association des bibliothèques de recherche du Canada. Room / Pièce 239. 65 University Private / 65 université privé. Ottawa ON K1N 9A5 Tel / tél : 613.562.5385 Fax / téléc : 613.562.5195 www.carl-abrc.ca «J'ai lu avec beaucoup d'intêret et d'enthousiasme l'article Statistiques 2004-2005 et 2005 des bibliothèques universitaires et de recherche au Canada qui vient de paraître dans la revue Documentation et bibliothèques. Permettez-moi de vous féliciter, madame, sur un article qui démontre un haut niveau de recherche et d'analyse. A titre d'intérêt, l'article sera mentionné dans notre publication hebdomadaire "Cyberavis" demain. ( Prière de consulter le site web de l'ABRC). Recevez, madame, mes salutations less meilleures. Tim Mark. (Courriel daté du 14 février 2008) ==========================================

Farmacocinética da gentamicina asministrada pela via intravensa regional em equinos com a utilização de modelos de torniques

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Basic control of reperfusion effectively protects against reperfusion injury in a realistic rodent model of acute limb ischemia

BACKGROUND: Reperfusion injury is insufficiently addressed in current clinical management of acute limb ischemia. Controlled reperfusion carries an enormous clinical potential and was tested in a new reality-driven rodent model. METHODS AND RESULTS: Acute hind-limb ischemia was induced in Wistar rats and maintained for 4 hours. Unlike previous tourniquets models, femoral vessels were surgically prepared to facilitate controlled reperfusion and to prevent venous stasis. Rats were randomized into an experimental group (n=7), in which limbs were selectively perfused with a cooled isotone heparin solution at a limited flow rate before blood flow was restored, and a conventional group (n=7; uncontrolled blood reperfusion). Rats were killed 4 hours after blood reperfusion. Nonischemic limbs served as controls. Ischemia/reperfusion injury was significant in both groups; total wet-to-dry ratio was 159+/-44% of normal (P=0.016), whereas muscle viability and contraction force were reduced to 65+/-13% (P=0.016) and 45+/-34% (P=0.045), respectively. Controlled reperfusion, however, attenuated reperfusion injury significantly. Tissue edema was less pronounced (132+/-16% versus 185+/-42%; P=0.011) and muscle viability (74+/-11% versus 57+/-9%; P=0.004) and contraction force (68+/-40% versus 26+/-7%; P=0.045) were better preserved than after uncontrolled reperfusion. Moreover, subsequent blood circulation as assessed by laser Doppler recovered completely after controlled reperfusion but stayed durably impaired after uncontrolled reperfusion (P=0.027). CONCLUSIONS: Reperfusion injury was significantly alleviated by basic modifications of the initial reperfusion period in a new in vivo model of acute limb ischemia. With this model, systematic optimizations of according protocols may eventually translate into improved clinical management of acute limb ischemia.