Avaliação de desinfetantes químicos de uso doméstico contra Vibrio cholerae EL TOR (amostra não toxigênica)

As metodologias de avaliação microbiológica de desinfetantes são permanentemente questionadas porque os protocolos laboratoriais não representam as condições reais de uso desses produtos. Em 1985, adotou-se no Brasil, a metodologia da Diluição-Uso da AOAC, para a qualificação microbiológica de desinfetantes químicos, para fins comerciais. Desta maneira, os desinfetantes domésticos são testados contra amostras padrões de Salmonella choleraesuis e Staphylococcus aureus. Pesquisou-se o emprego de Vibrio cholerae devido a sua atual importância, no Brasil, em termos de Saúde Pública, associada ao estudo da atividade antimicrobiana de desinfetantes. Dezenove produtos desinfetantes de uso doméstico encontrados no comércio foram microbiologicamente avaliados. A metodologia foi a Diluição-Uso com 10 carreadores. Os compostos ativos dos produtos incluíam: formaldeído, fenóis, cresóis, amônio quaternário, cloro e etanol, sendo que sete, eram de composição associada. Conforme as recomendações de uso, dezesseis produtos, devem ser utilizados sem diluição. Nestas condições, 9 desinfetantes foram vibriocidas e sete não revelaram tal atividade antibacteriana. Quatro produtos em diluições não esclarecedoras para a desinfecção também mostraram-se ineficazes. Os produtos vibriocidas que devem ser utilizados sem diluição, foram reavaliados diluídos ao dobro. Estas soluções não inativaram V.cholerae, demonstrando microbiologicamente que os seus compostos ativos estão em concentrações limítrofes. O álcool comercial (95,5° GL) a 1:3, a "água sanitária" (2,8% de cloro ativo) a 1:200, creolina a 1:10 e o "Lysoform" a 1:20 atingiram os padrões do teste.

DETECÇÃO DO Vibrio cholerae BIOTIPO EL TOR SOROGRUPO IΝΑΒΑ NO RIO SOLIMÕES - MAIO/91

Foi efetuada a pesquisa do Vibrio cholerae em 41 amostras do água, coletadas de algumas localidades da região do alto Solimões através da técnica de Moore mod.: Tabatinga (Brasil) = 13 amostras; Benjamin Constant (Brasil) = 7 amostras: Ilha de Islândia (Peru) = 2 amostras: Ilha de Santa Rosa (Peru) = 19 amostras. Não houve isolamento do Vibrio cholerae da água, dos Municípios de Tabatinga e Benjamin Constant - Brasil e Ilha de Islândia - Peru. Houve o isolamento do Vibrio cholerae biotipo El Tor sorogrupo Inaba de 4 (21 %) amostras de água coletada de 19 diferentes pontos localizados à margem direita do Rio Solimões, na Ilha de Santa Rosa - Peru. O Vibrio cholerae detectado apresentou-se sorologicamente igual ao responsável pela cólera na região do alto Solimões. O isolamento do Vibrio cholerae da água do Rio Solimões leva-nos a responsabilizá-la como sendo um dos veículos de disseminação do bacilo, como também da doença.

Avaluació de nous algorismes per a la creació de camins entre nodes de la xarxa TOR

En este proyecto se presenta un estudio y una implementación sobre estrategias de selección de nodos de la red TOR. Para esto en una primera parte teorica se da a conocer todo lo que comportan las redes anónimas y su implementación en diferentes entornos. A continuación se estudian los requerimientos y la viabilidad del proyecto. Finalmente exponemos el diseño y desarrollo de los distintos algoritmos propuestos juntamente con las pruebas realizadas y las conclusiones a las que se ha llegado.

Regression of cardiac growth in kidney transplant recipients using anti-m-TOR drugs plus RAS blockers: a controlled longitudinal study.

BACKGROUND Left ventricular hypertrophy (LVH) is common in kidney transplant (KT) recipients. LVH is associated with a worse outcome, though m-TOR therapy may help to revert this complication. We therefore conducted a longitudinal study to assess morphological and functional echocardiographic changes after conversion from CNI to m-TOR inhibitor drugs in nondiabetic KT patients who had previously received RAS blockers during the follow-up. METHODS We undertook a 1-year nonrandomized controlled study in 30 non-diabetic KT patients who were converted from calcineurin inhibitor (CNI) to m-TOR therapy. A control group received immunosuppressive therapy based on CNIs. Two echocardiograms were done during the follow-up. RESULTS Nineteen patients were switched to SRL and 11 to EVL. The m-TOR group showed a significant reduction in LVMi after 1 year (from 62 ± 22 to 55 ± 20 g/m2.7; P=0.003, paired t-test). A higher proportion of patients showing LVMi reduction was observed in the m-TOR group (53.3 versus 29.3%, P=0.048) at the study end. In addition, only 56% of the m-TOR patients had LVH at the study end compared to 77% of the control group (P=0.047). A significant change from baseline in deceleration time in early diastole was observed in the m-TOR group compared with the control group (P=0.019). CONCLUSIONS Switching from CNI to m-TOR therapy in non-diabetic KT patients may regress LVH, independently of blood pressure changes and follow-up time. This suggests a direct non-hemodynamic effect of m-TOR drugs on cardiac mass.

Comparative genomics of the vertebrate insulin/TOR signal transduction pathway: A network-level analysis of selective pressures

Complexity of biological function relies on large networks of interacting molecules. However, the evolutionary properties of these networks are not fully understood. It has been shown that selective pressures depend on the position of genes in the network. We have previously shown that in the Drosophila insulin/target of rapamycin (TOR) signal transduction pathway there is a correlation between the pathway position and the strength of purifying selection, with the downstream genes being most constrained. In this study, we investigated the evolutionary dynamics of this well-characterized pathway in vertebrates. More specifically, we determined the impact of natural selection on the evolution of 72 genes of this pathway. We found that in vertebrates there is a similar gradient of selective constraint in the insulin/TOR pathway to that found in Drosophila. This feature is neither the result of a polarity in the impact of positive selection nor of a series of factors affecting selective constraint levels (gene expression level and breadth, codon bias, protein length, and connectivity). We also found that pathway genes encoding physically interacting proteins tend to evolve under similar selective constraints. The results indicate that the architecture of the vertebrate insulin/TOR pathway constrains the molecular evolution of its components. Therefore, the polarity detected in Drosophila is neither specific nor incidental of this genus. Hence, although the underlying biological mechanisms remain unclear, these may be similar in both vertebrates and Drosophila.

[Palestrina. Tor de Schiavi]

Référence bibliographique : Weigert, 323

[Palestrina. Tor de Schiavi]

Référence bibliographique : Weigert, 324

[Palestrina. Tor de Schiavi]

Référence bibliographique : Weigert, 325

Estudi del Saló Internacional del Llibre de Torí

Estudi sobre l'edició de l'any 2013 del Saló Internacional del Llibre de Torí. Anàlisi del funcionament del Saló -activitats, espais i propostes-, importància de la internacionalització, possibilitats reals de negoci i transacció comercial i, per últim, rendibilitat de la celebració del Saló. Tot això tenint en compte el context de globalització i de digitalització que pateix actualment el sector del llibre.

El llibre dels Morts; el Papir de Torí

El projecte “El Llibre dels Morts; el Papir de Torí” és un estudi on s’hi exposa l’evolució que ha patit aquest text dels antics egipcis fins arribar al seu estat final. En aquest s’hi inclou una anàlisi concreta del Papir de Torí, conservat al Museu Egipci de Torí (Itàlia). La primera part és un context d’aquest Llibre dels Morts en el qual s’analitzen els antecedents que aquest text pot tenir des dels seus orígens, els centres religiosos que hi apareixen reflectits i també les recensions fetes en l’època faraònica i els estudis d’egiptologia més destacats sobre aquest tema. Finalment es durà a terme una anàlisi d’un dels primers papirs que van ser transcrits, el Papir de Torí. Paraules

Hvordan øve hellige handlinger? : en profesjonsdidaktisk studie av øving av muntlige ferdigheter innenfor en norsk presteutdanning

How can the holy craft of liturgy be trained? A study of approaches to instruction in training oral skills within education of the Norwegian clergy The theme of this study is the competence of expression of clerics performing liturgies as part of their duties in the Norwegian Lutheran Church. The aim of the study is to find a teaching practice which can raise the competence in oral expression characteristic of the clergy profession. The teaching practice is explored and discussed within the context of the basic education of the clergy. The main thesis is formulated as a question: How can the holy craft of liturgy be trained? An underpinning of the study is that liturgical acts are holy, which gives these performances an aspect of otherness. This otherness constitutes a clear agreement between the students and the teacher, and between the professional and the employer. The pre-understanding of the researcher is that these liturgical oral acts are trainable, and that there is a need and a necessity to train in these skills. Three research questions are elaborated on in the explorative section of the study: • What is characteristic of a competence of expression connected to the profession? • How can this competence of expression connected to liturgical performance be developed? • What is the importance of this competence in the holy craft of liturgy for the development of a cohesive professional self-understanding? The study is based on a research and development project where the researcher as the teacher and students from one specific clergy education in Norway (MF) were the source of the empirical material. The empirical data came from practice with two external observers› logs on the coaching, video observations, of the teacher and the students› texts on the practice under study, which is liturgical performance. The researcher›s log and field notes also provide material for the analysis. This is a qualitative project and an arts education project carried out within an interpretative framework. The theoretical framework has three perspectives: a structural approach based on the system theory of Niklas Luhmann, an epistemological approach discussing forms of knowledge in practice or informing practice and an arts education approach. The results indicate that the competence in oral liturgical performance can be considered a trainable skill, and that this training can be understood as an arts education method of instruction based on meaningful communication, dramaturgical thinking and the development of authenticity. The main result from this study can be considered as articulating and sketching the contours of the field of knowledge where the students embody the meaning of the clergy profession ‒ and this articulation has an innovative potential as knowledge combining experience and theoretical understanding.

Myyntisopimus Mo-no-ra-tor-kaasuttimille

25 x 32 cm