30 resultados para Stroh


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The Eva Stroh Family Collection provides material on the lives and family history of members of the Sondheimer and Stroh families. The collection consists of numerous photos and several photo albums, family trees, official documents, correspondence, published articles and clippings and some notes, a notebook documenting cultural activities and some daily calendars.

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Welsch (Projektbearbeiter): Das Oberkommando der Nationalgarde delegiert die Ausgabe von Brot, Wein, Tabak, Beleuchtungs- und Brennmaterial, Pferdefutter und Stroh an eine "Approvisionirungs-Commission im Magistratsgebäude."

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Signatur des Originals: S 36/G01044

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Background: Findings from the phase 3 FLEX study showed that the addition of cetuximab to cisplatin and vinorelbine significantly improved overall survival, compared with cisplatin and vinorelbine alone, in the first-line treatment of EGFR-expressing, advanced non-small-cell lung cancer (NSCLC). We investigated whether candidate biomarkers were predictive for the efficacy of chemotherapy plus cetuximab in this setting. Methods: Genomic DNA extracted from formalin-fixed paraffin-embedded (FFPE) tumour tissue of patients enrolled in the FLEX study was screened for KRAS codon 12 and 13 and EGFR kinase domain mutations with PCR-based assays. In FFPE tissue sections, EGFR copy number was assessed by dual-colour fluorescence in-situ hybridisation and PTEN expression by immunohistochemistry. Treatment outcome was investigated according to biomarker status in all available samples from patients in the intention-to-treat population. The primary endpoint in the FLEX study was overall survival. The FLEX study, which is ongoing but not recruiting participants, is registered with ClinicalTrials.gov, number NCT00148798. Findings: KRAS mutations were detected in 75 of 395 (19%) tumours and activating EGFR mutations in 64 of 436 (15%). EGFR copy number was scored as increased in 102 of 279 (37%) tumours and PTEN expression as negative in 107 of 303 (35%). Comparisons of treatment outcome between the two groups (chemotherapy plus cetuximab vs chemotherapy alone) according to biomarker status provided no indication that these biomarkers were of predictive value. Activating EGFR mutations were identified as indicators of good prognosis, with patients in both treatment groups whose tumours carried such mutations having improved survival compared with those whose tumours did not (chemotherapy plus cetuximab: median 17·5 months [95% CI 11·7-23·4] vs 8·5 months [7·1-10·8], hazard ratio [HR] 0·52 [0·32-0·84], p=0·0063; chemotherapy alone: 23·8 months [15·2-not reached] vs 10·0 months [8·7-11·0], HR 0·35 [0·21-0·59], p<0·0001). Expression of PTEN seemed to be a potential indicator of good prognosis, with patients whose tumours expressed PTEN having improved survival compared with those whose tumours did not, although this finding was not significant (chemotherapy plus cetuximab: median 11·4 months [8·6-13·6] vs 6·8 months [5·9-12·7], HR 0·80 [0·55-1·16], p=0·24; chemotherapy alone: 11·0 months [9·2-12·6] vs 9·3 months [7·6-11·9], HR 0·77 [0·54-1·10], p=0·16). Interpretation: The efficacy of chemotherapy plus cetuximab in the first-line treatment of advanced NSCLC seems to be independent of each of the biomarkers assessed. Funding: Merck KGaA. © 2011 Elsevier Ltd.

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利用Lekhnitskii理论和Stroh理论的相互联系,把已知的基于Lekhnitskii理论平面应变结果转化为Stroh理论形式的结果,直接获得Stroh公式中A,B的显式表达式,此方法可扩展到平面应力情况,然后导出压电材料平面应变问题的尖端场Williams形式的展开式,采用半权函数法计算有限大压电体平面问题应力和电位移强度因子.对无穷大板含中心裂纹的情况下本文结果和已有结果进行了比较,表明本文方法得到的结果精度可靠.本文方法的最大优点是可以求解有限压电体的应力强度因子,并且需要的单元少,精度高,实用性好.

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压电陶瓷因具有良好的压电性而被广泛应用于智能结构。在工作状态下,由力或电载荷引起的应力或电位移的集中会导致压电元件的力电失效。本论文对压电陶瓷板的力电集中和断裂问题进行探讨。首次应用Rei ssner理论对含孔、裂纹压电板的弯曲问题进行了研究,得出了孔边和裂纹尖端场的力电分布形式;应用半权函数方法分析计算含裂纹压电板应力强度因子。全文包括以下几部分:(一)含孔压电板的弯曲基于Reissner板理论,结合有限元法和解析法研究含孔压电板的力电集中问题。给出了上下表面电源短路、含孔压电板方程的通解。计算了含圆孔无穷大压电板受纯弯曲作用的力电集中问题。结果表明:1)压电效应对面内弯曲正应力的影响很小,可忽略不计。2)压电效应对剪应力影响较大,切向电场强度和电位移的集中程度随径厚比变化趋势和切向剪力的变化趋势相同。3)中面上孔边电势和垂直于板中面的电场强度的集中程度随径厚比的减小而减弱,垂直于中面的电位移的集中程度随着径厚比的减小而增强。(二)含裂纹压电板的拉伸和弯曲(极化轴垂直于板的中面)用双重级数展开方法给出了基于Reissner板理论压电板的裂纹尖端奇异场。研究得出:垂直于板面的电场强度不奇异,但是电位移是奇异的;在裂纹尖端的奇异场里,板面内弯曲应力与电场无关,同时面内电位移奇异且只与剪力有关,垂直于板面的电位移与弯曲应力有关。计算了受纯弯矩作用含中心裂纹的压电矩形板,并与非压电材料板情况进行了比较,结果表明:压电效应对应力强度因子影响不大,可以忽略不计,因此可以用含裂纹的各向同性非压电板计算应力强度因子,并得出垂直于板面的电位移。(三)含裂纹压电板的拉伸和弯曲(极化轴平行于板的中面)基于Reissner板理论,分析了含裂纹且极化轴平行于板中面的压电板拉伸和弯曲问题。研究表明,当板的上下表面没有剪力和电荷载,只在板边加电荷载和力的情况下,此问题可以分解为压电材料的平面应力断裂和各向异性板的弯曲断裂问题。对于含裂纹压电材料的平面应力问题,利用Stroh理论导出压电材料平面问题尖端场Wiiliams形式的展开式。计算了有限压电板含中心裂纹受纯弯曲和板边加电荷载作用的断裂问题。得出以下结论:各向异性板受纯弯曲作用时,由线性压电材料的本构关系可以得出电位移的奇异性;整个问题电位移奇异性是由受电荷载作用的平面应力问题和受纯弯曲作用的各向异性板弯曲问题各自引起的电位移奇异性的叠加。(四)计算含裂纹压电板应力强度因子的半权函数法本文对含裂纹压电板的应力强度因子计算都采用了半权函数法。由功能互等定理导出用半权函数和积分围道裂纹尖端的参考场所表示的所研究情况的应力强度因子的表达式。对多种情况进行了计算,并与相关结果进行了比较,结果表明:此方法需要的单元少,精度高,实用性好。利用本文方法对实际应用中出现的有限尺寸压电介质断裂问题进行分析,为压电元件的力电祸合性态研究及其可靠性预测提供理论依据。

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NaA zeolite membrane was successfully synthesized on a ceramic hollow fiber with an outer diameter of 400 mum, a thickness of 100 mum and an average pore radius of 0.1 mum. The as-synthesized membranes were characterized by XRD, SEM as well as gas permeation. A continuous C NaA zeolite membrane formed after a three-stage synthesis. The membrane thickness was similar to5 mum. Gas permeation data indicated that a relatively high quality NaA zeolite membrane formed on the ceramic hollow fiber support. (C) 2003 Elsevier B.V. All rights reserved.

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Partial oxidation of n-heptane (POH) for hydrogen generation was studied over several catalysts between 700 and 850degreesC. Modified Ni-based/gamma-Al2O3 catalyst exhibited not only good catalytic activity but also good carbon deposition resistance ability. Under the modified reaction conditions, 100% n-heptane conversion and 93% hydrogen selectivity can be obtained.

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A high quality NaA zeolite membrane, which shows a H-2/n-C4H10 permselectivity of 106, has been synthesized on a seeded alpha-Al2O3 support by a multistage synthesis method.

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Mesoporous spinel membranes as ultrafiltration membranes were prepared through a novel sol-gel technique. By in situ modification of the sol particle surface during the sol-gel process, control of the material structure on a nanometer scale from the earliest stages of processing was realized. Nano-particles with a chocolate-nut-like morphology, i.e. spinel MgAl2O4 as a shell and gamma -Al2O3 as a core, were first revealed by HRTEM results. The formation of the spinel phase was confirmed by X-ray diffraction (XRD). N-2 adsorption-desorption results showed that the mesoporous membranes had a narrow pore size distribution. (C) 2001 Elsevier Science B.V. All rights reserved.