An appeal to the public, in compliance with the mandate of the ref. G.C. Smith, of Penzance.

Mode of access: Internet.

Spencer Kellogg Brown, his life in Kansas and his death as a spy, 1842-1863, as disclosed in his diary,

Mode of access: Internet.

George W. Smith (late a representative from Illinois) Memorial addresses, Sixtieth Congress, First and Second sessions, House of Representatives, April 19, 1908. Senate of the United States, December 15, 1908.

"Proceedings in the Senate": p. 50-59.

Life of George R. Smith, founder of Sedalia, Mo., in its relations to the political, economic, and social life of southwestern Missouri, before and during the Civil War,

Mode of access: Internet.

Spencer Kellogg Brown, his life in Kansas and his death as a spy, 1842-1863 : as disclosed in his diary.

Mode of access: Internet.

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10−9 to P = 1.8 × 10−40) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10−3 to P = 1.2 × 10−13). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

Franks family papers, 1711-1821, [1965-1968].

Contains business correspondence, accounts and documents relating to Jacob Franks of New York, his two sons, Moses and David, a nephew, Isaac, and a John Franks of Halifax, possibly a member of the family.

Directional dominance on stature and cognition in diverse human populations

Homozygosity has long been associated with rare, often devastating, Mendelian disorders1, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3, 4. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10−300, 2.1 × 10−6, 2.5 × 10−10 and 1.8 × 10−10, respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months’ less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5, 6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.

University of Michigan Football Team, 1901

Top Row: Wesley Winkler, Ralph Drake, Charles Rothschild, Norman Sterry, Kenneth Robinson, Alfred Chadwick, Weldon Fix, Ross Kidston, Les Barkenbus, Harrison Weeks, David Dunlap, George Gregory, Harold Baker, Cecil Gooding, George Sadler

Third Row: student mngr. H.C. Crafts, Edward Dickey(?), David Beardsley, William Snushall, ? Smith, George Davison, Kennedy Potter, ? Clark, Charles Van Valkenberg, Neil Snow, Joseph Horgan, James Forrest, William Foote, Webb Sadler, ? Hayes

Second Row: trainer Keene Fitzpatrick, ? Smith, Samuel Sackett, Everett Sweeley, Herbert Graver, Walter Shaw, Hugh White, Albert Herrnstein, Curtis Redden, Dan McGugin, Ebin Wilson, Bruce Shorts, Arthur Redner, Temple Owens

Front Row: Ralph Husson, Albert Preussman, Arthur Urquhart, Willie Heston, Benjamin Southworth, coach Fielding Yost, Charles Crane, Jerome (mascot), John Lewis, Frank Doty, Frank Belknap

George, third earl of Cumberland (1558-1605) his life and his voyages, a study from original documents,

Bibliography: p. [314]-318.

The Cornhill magazine.

Published in London by J. Murray, <1947->.