De corixos e de veredas: a alegada similitude entre as poéticas de Manoel de Barros e de Guimarães Rosa

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Antiresorptive drugs (bisphosphonates), atypical fractures and rebound effect: new evidence of similitude

Background: Homeopathy is based on treatment by similitude ('like cures like') administering to sick individuals substances that cause similar symptoms in healthy individuals, employing the secondary and paradoxical action of the organism as therapeutic response. This vital or homeostatic reaction of the organism can be scientifically explained by the rebound effect of drugs, resulting in worsening of symptoms after suspension of treatment. Bisphosphonates (BPs) reduce 'typical' fractures in patients with osteoporosis, but recent studies report 'atypical' fractures of the femur after stopping the BPs, a rebound effect may be the causal mechanism. Method: Review of the literature concerning the relationship between atypical femoral fractures and antiresorptive drugs (bisphosphonates), identifying the pathogenesis of this adverse event. Results: Several studies have described multiple cases of 'atypical' low-impact subtrochanteric stress fractures or complete fractures of the femur. These fractures are often bilateral, preceded by pain in the affected thigh, may have a typical X-ray appearance, and may delayed healing. Rebound of osteoclastic activity after suspension of antiresorptive drugs is a plausible mechanism to explain this phenomenon. Conclusion: As for other classes of drugs, the rebound effect of antiresorptive drugs supports Hahnemann's similitude principle (primary action of the drugs followed by secondary and opposite action of the organism), and clarifies this 'unresolved' issue. Unfortunately, the rebound effect is little discussed among health professionals, depriving them of important knowledge ensure safe management of drugs. Homeopathy (2012) 101, 231-242.

A similitude for nonequilibrium phenomena in hypersonic flight,

"Part I of the present paper was supported by the Arnold Engineering Development Center under Contract no. AF-40-(601)-928. Part II is a part of project DEFENDER sponsored by the Advanced Research Projects Agency, Department of Defense, under Contract no. DA-30-069-ORD-3443."

The pilgrim's progress from this world to that which is to come : delivered under the similitude of a dream. Wherein is discovered I. The matter of his setting out. II. His dangerous journey; and III. His safe arrival at the desired country. Complete in two parts. With the life of the author prefixed /

Mode of access: Internet.

The pilgrims' progress, from this world, to that which is to come. Delivered under the similitude of a dream. In two parts.

Mode of access: Internet.

The pilgrim's progress : from this world to that which is to come, delivered under the similitude of a dream ; in two parts /

The engravings are signed by Anderson.

The pilgrim's progress from this world to that which is to come; delivered under the similitude of a dream.

Added engraved t.p., with vignette.

The pilgrim's progress from this world to that which is to come. Delivered under the similitude of a dream. In two parts. ... A new edition, divided into chapters. With the life of the author. To which are added explanatory and practical notes, by the Rev. Messrs. Mason, Scott, and Burder. Also, a key to the allegory, with a critique on its beauties. Embellished with elegant engravings, designed by Richard Westall, R.A.

Pages [3],276-496 contain his: The Pilgrim's progress ... Part the second... New York, l822, with special title page.

The pilgrim's progress from this world to that which is to come. Delivered under the similitude of a dream. In two parts.

Mode of access: Internet.

The pilgrim's progress from this world to that which is to come : delivered under the similitude of a dream /

Mode of access: Internet.

The pilgrim's progress from this world to that which is to come : delivered under the similitude of a dream /

Mode of access: Internet.

The loss and recovery of elect sinners: with the difficulty of their coming back again to glory, methodically held forth under the similitude of captives ransomed and returning from slavery;

Page xiii incorrectly numbered xii.

Similitude for normal shock waves in nonequilibrium flows

Mode of access: Internet.