Letters illustrative of the reign of William III from 1696 to 1708 : addressed to the Duke of Shrewsbury /

'Now first published from the originals.'--t.p.

Shrewsbury burgess roll,

Mode of access: Internet.

The register of Ralph of Shrewsbury, bishop of Bath and Wells, 1329-1363.

Mode of access: Internet.

Hardwick Hall, Co. of Derby : erected by Elizabeth Hardwick, Countess of Shrewsbury, 1590-1597, now one of the residences of her descendant His Grace the Duke of Devonshire, K.G.

Contains a catalogue of the portraits in Hardwick hall.

Per le faustissime nozze dell' ee. ll. d. Marco Antonio Borghese, principe di Sulmona, e donna Guendelina Talbot, dei conti di Shrewsbury ec. ec.: rime.

Mode of access: Internet.

A letter to Sir William Pulteney, bart., representative in Parliament for the borough of Shrewsbury : containing some observations on the Bill for the better support and maintenance of the poor, presented to the House of Commons by the Right Hon. William Pitt /

Goldsmiths'-Kress no. 17133.

A sermon, delivered at Shrewsbury,

Mode of access: Internet.

A sermon, delivered at the funeral of the Rev. Edwards Whipple, late junior pastor of the church in Shrewsbury. September, 1822.

Mode of access: Internet.

Case study: Digital life: e-safety and safeguarding

Case study on how Shrewsbury College has redeveloped their induction training for staff and students to enhance safeguarding and e-safety.

Assessment of the hydrogeological impacts of aggregate extraction in the Delamere area, Cheshire

This is a technical report on the assessment of the hydrogeological impacts of aggregate extraction activities in the Delamere Area, Cheshire. The first aim of the study was to carry out Stage 3-appropriate assessment, under the EU Habitats Directive (92/43/EEC), of the possible hydrogeological impacts of aggregate extraction activities authorised by the Cheshire CC on candidate Special Areas of Conservation (cSAC) on the Delamere sandsheet, Cheshire. Identifying possible impacts if these activities on the hydrogeological environment, construction of a numerical groundwater flow model of the groundwater system to investigate and quantify impacts and to produce a report as required under Stage 3 of the Habitats Regulations. Secondly, to identify the future potential impacts of the continued extraction of sand and gravel reserves from above and below the water tables from within the Delamere sandsheet, thus releasing reserves identified within the Area of Search of the Cheshire Replacement Minerals Local Plan 1999. This aspect of the study should assist in identifying the implications of further working within Delamere for North West sub-regional apportionment.

Characterisation of a novel panel of polymorphic microsatellite loci for the liver fluke, Fasciola hepatica, using a next generation sequencing approach

The liver fluke, Fasciola hepatica is an economically important pathogen of sheep and cattle and has been described by the WHO as a re-emerging zoonosis. Control is heavily reliant on the use of drugs, particularly triclabendazole and as a result resistance has now emerged. The population structure of F. hepatica is not well known, yet it can impact on host-parasite interactions and parasite control with drugs, particularly regarding the spread of triclabendazole resistance. We have identified 2448 potential microsatellites from 83Mb of F. hepatica genome sequence using msatfinder. Thirty-five loci were developed and optimised for microsatellite PCR, resulting in a panel of 15 polymorphic loci, with a range of three to 15 alleles. This panel was validated on genomic DNA from 46 adult F. hepatica; 38 liver flukes sourced from a Northwest abattoir, UK and 8 liver flukes from an established isolate (Shrewsbury; Ridgeway Research). Evidence for null alleles was found at four loci (Fh_1, Fh_8, Fh_13 and Fh_14), which showed markedly higher levels of homozygosity than the remaining 11 loci. Of the 38 liver flukes isolated from cattle livers (n=10) at the abattoir, 37 genotypes were identified. Using a multiplex approach all 15 loci could be amplified from several life cycle stages that typically yield low amounts of DNA, including metacercariae, the infective life cycle stage present on pasture, highlighting the utility of this multiplex microsatellite panel. This study reports the largest panel of microsatellite markers available to date for population studies of F. hepatica and the first multiplex panel of microsatellite markers that can be used for several life cycle stages.