Vínculos urbano-rurales y construcción de nuevas territorialidades en asentamientos de rango menor

La homogeneización productiva ha trastocado los procesos de construcción territorial induciendo cambios en la naturaleza, intensidad y direccionalidad de los vínculos urbano-rurales en región pampeana. La creación de nuevas articulaciones y/o la redefinición de las interacciones preexistentes involucran dimensiones funcionales, institucionales y espaciales, dando origen a formas específicas de resolución territorial. A partir de enfoques superadores de las aproximaciones sectoriales y dualistas intrínsecas al paradigma de la modernización, que han impregnado la interpretación de procesos de construcción territorial a partir de la oposición "campo-ciudad", se propone la indagación a partir de la convergencia de macroprocesos que trastocan las trayectorias territoriales, al tiempo que renuevan la naturaleza de los vínculos urbano-rurales (avance de la pluriactividad, emergencia de nuevos actores y usos del suelo en los espacios rurales, urbanización difusa). Dentro de esta perspectiva, los asentamientos de rango menor en región pampeana, constituyen ámbitos privilegiados para la exploración de las modalidades que asumen las articulaciones urbano-rurales, en tanto lugares alcanzados por el proceso de homogeneización productiva, mostrando cómo la emergencia de nuevos actores, lógicas y escalas de acción, interpela las aproximaciones tradicionales de análisis de los vínculos urbano-rurales y exige la necesidad de renovar enfoques, regulaciones e instrumentos solidarios con la gestión territorial sustentable

Vínculos urbano-rurales y construcción de nuevas territorialidades en asentamientos de rango menor

La homogeneización productiva ha trastocado los procesos de construcción territorial induciendo cambios en la naturaleza, intensidad y direccionalidad de los vínculos urbano-rurales en región pampeana. La creación de nuevas articulaciones y/o la redefinición de las interacciones preexistentes involucran dimensiones funcionales, institucionales y espaciales, dando origen a formas específicas de resolución territorial. A partir de enfoques superadores de las aproximaciones sectoriales y dualistas intrínsecas al paradigma de la modernización, que han impregnado la interpretación de procesos de construcción territorial a partir de la oposición "campo-ciudad", se propone la indagación a partir de la convergencia de macroprocesos que trastocan las trayectorias territoriales, al tiempo que renuevan la naturaleza de los vínculos urbano-rurales (avance de la pluriactividad, emergencia de nuevos actores y usos del suelo en los espacios rurales, urbanización difusa). Dentro de esta perspectiva, los asentamientos de rango menor en región pampeana, constituyen ámbitos privilegiados para la exploración de las modalidades que asumen las articulaciones urbano-rurales, en tanto lugares alcanzados por el proceso de homogeneización productiva, mostrando cómo la emergencia de nuevos actores, lógicas y escalas de acción, interpela las aproximaciones tradicionales de análisis de los vínculos urbano-rurales y exige la necesidad de renovar enfoques, regulaciones e instrumentos solidarios con la gestión territorial sustentable

Vínculos urbano-rurales y construcción de nuevas territorialidades en asentamientos de rango menor

La homogeneización productiva ha trastocado los procesos de construcción territorial induciendo cambios en la naturaleza, intensidad y direccionalidad de los vínculos urbano-rurales en región pampeana. La creación de nuevas articulaciones y/o la redefinición de las interacciones preexistentes involucran dimensiones funcionales, institucionales y espaciales, dando origen a formas específicas de resolución territorial. A partir de enfoques superadores de las aproximaciones sectoriales y dualistas intrínsecas al paradigma de la modernización, que han impregnado la interpretación de procesos de construcción territorial a partir de la oposición "campo-ciudad", se propone la indagación a partir de la convergencia de macroprocesos que trastocan las trayectorias territoriales, al tiempo que renuevan la naturaleza de los vínculos urbano-rurales (avance de la pluriactividad, emergencia de nuevos actores y usos del suelo en los espacios rurales, urbanización difusa). Dentro de esta perspectiva, los asentamientos de rango menor en región pampeana, constituyen ámbitos privilegiados para la exploración de las modalidades que asumen las articulaciones urbano-rurales, en tanto lugares alcanzados por el proceso de homogeneización productiva, mostrando cómo la emergencia de nuevos actores, lógicas y escalas de acción, interpela las aproximaciones tradicionales de análisis de los vínculos urbano-rurales y exige la necesidad de renovar enfoques, regulaciones e instrumentos solidarios con la gestión territorial sustentable

Validations of high-rank syntaxa in Potamogetonetea and Scheuchzerio-Caricetea fuscae

This paper presents the validation of five syntaxonomic concepts –two orders (Callitricho hamulatae-Ranunculetalia aquatilis, Zannichellietalia pedicellatae) and three alliances (Ranunculion aquatilis, Nelumbion nuciferae and Caricion viridulo-trinervis).

Characterization and application of two RANK-specific antibodies with different biological activities.

Antibodies play an important role in therapy and investigative biomedical research. The TNF-family member Receptor Activator of NF-κB (RANK) is known for its role in bone homeostasis and is increasingly recognized as a central player in immune regulation and epithelial cell activation. However, the study of RANK biology has been hampered by missing or insufficient characterization of high affinity tools that recognize RANK. Here, we present a careful description and comparison of two antibodies, RANK-02 obtained by phage display (Newa, 2014 [1]) and R12-31 generated by immunization (Kamijo, 2006 [2]). We found that both antibodies recognized mouse RANK with high affinity, while RANK-02 and R12-31 recognized human RANK with high and lower affinities, respectively. Using a cell apoptosis assay based on stimulation of a RANK:Fas fusion protein, and a cellular NF-κB signaling assay, we showed that R12-31 was agonist for both species. R12-31 interfered little or not at all with the binding of RANKL to RANK, in contrast to RANK-02 that efficiently prevented this interaction. Depending on the assay and species, RANK-02 was either a weak agonist or a partial antagonist of RANK. Both antibodies recognized human Langerhans cells, previously shown to express RANK, while dermal dendritic cells were poorly labeled. In vivo R12-31 agonist activity was demonstrated by its ability to induce the formation of intestinal villous microfold cells in mice. This characterization of two monoclonal antibodies should now allow better evaluation of their application as therapeutic reagents and investigative tools.

Eye color as an indicator of social rank in the fish Nile tilapia

We investigated the association of eye color with the dominant-subordinate relationship in the fish Nile tilapia, Oreochromis niloticus. Eye color pattern was also examined in relation to the intensity of attacks. We paired 20 size-matched fish (intruder: 73.69 ± 11.49 g; resident: 75.42 ± 8.83 g) and evaluated eye color and fights. These fish were isolated in individual aquaria for 10 days and then their eye color was measured 5 min before pairing (basal values). Twenty minutes after pairing, eye color and fights were quantified for 10 min. Clear establishment of social hierarchy was observed in 7 of 10 pairs of fish. Number of attacks ranged from 1 to 168 among pairs. The quartile was calculated for these data and the pairs were then divided into two classes: low-attack (1 to 111 attacks - 2 lower quartiles) or high-attack (112 to 168 attacks - 2 higher quartiles). Dominance decreased the eye-darkening patterns of the fish after pairing, while subordinance increased darkening compared to dominance. Subordinate fish in low-attack confrontations presented a darker eye compared to dominant fish and to the basal condition. We also observed a paler eye pattern in dominants that shared low-attack interactions after pairing compared to the subordinates and within the group. However, we found no differences in the darkening pattern between dominants and subordinates from the high-attack groups. We conclude that eye color is associated with social rank in this species. Moreover, the association between eye color and social rank in the low-attack pairs may function to reduce aggression.

Correcting for bias when estimating the cost of hospital-acquired infection : an analysis of lower respiratory tract infections in non-surgical patients

Hospital acquired infections (HAI) are costly but many are avoidable. Evaluating prevention programmes requires data on their costs and benefits. Estimating the actual costs of HAI (a measure of the cost savings due to prevention) is difficult as HAI changes cost by extending patient length of stay, yet, length of stay is a major risk factor for HAI. This endogeneity bias can confound attempts to measure accurately the cost of HAI. We propose a two-stage instrumental variables estimation strategy that explicitly controls for the endogeneity between risk of HAI and length of stay. We find that a 10% reduction in ex ante risk of HAI results in an expected savings of £693 ($US 984).

Functional outcome and usage of the prosthesis of lower limb amputees fitted with osseointegrated fixation

This study established that the core principle underlying categorisation of activities have the potential to provide more comprehensive outcomes than the recognition of activities because it takes into consideration activities other than directional locomotion.

Categorisation of activities of daily living of lower limb amputees during short-term use of a portable kinetic recording system : a preliminary study

The purpose of this preliminary study was to determine the relevance of the categorization of the load regime data to assess the functional output and usage of the prosthesis of lower limb amputees. The objectives were a) to introduce a categorization of load regime, b) to present some descriptors of each activity, and c) to report the results for a case. The load applied on the osseointegrated fixation of one transfemoral amputee was recorded using a portable kinetic system for 5 hours. The periods of directional locomotion, localized locomotion, and stationary loading occurred 44%, 34%, and 22% of recording time and each accounted for 51%, 38%, and 12% of the duration of the periods of activity, respectively. The absolute maximum force during directional locomotion, localized locomotion, and stationary loading was 19%, 15%, and 8% of the body weight on the anteroposterior axis, 20%, 19%, and 12% on the mediolateral axis, and 121%, 106%, and 99% on the long axis. A total of 2,783 gait cycles were recorded. Approximately 10% more gait cycles and 50% more of the total impulse than conventional analyses were identified. The proposed categorization and apparatus have the potential to complement conventional instruments, particularly for difficult cases.

Quantitative studies of lower motor neuron degeneration in amyotrophic lateral sclerosis : Evidence for exponential decay of motor unit numbers and greatest rate of loss at the site of onset

Objective: To use our Bayesian method of motor unit number estimation (MUNE) to evaluate lower motor neuron degeneration in ALS. Methods: In subjects with ALS we performed serial MUNE studies. We examined the repeatability of the test and then determined whether the loss of MUs was fitted by an exponential or Weibull distribution. Results: The decline in motor unit (MU) numbers was well-fitted by an exponential decay curve. We calculated the half life of MUs in the abductor digiti minimi (ADM), abductor pollicis brevis (APB) and/or extensor digitorum brevis (EDB) muscles. The mean half life of the MUs of ADM muscle was greater than those of the APB or EDB muscles. The half-life of MUs was less in the ADM muscle of subjects with upper limb than in those with lower limb onset. Conclusions: The rate of loss of lower motor neurons in ALS is exponential, the motor units of the APB decay more quickly than those of the ADM muscle and the rate of loss of motor units is greater at the site of onset of disease. Significance: This shows that the Bayesian MUNE method is useful in following the course and exploring the clinical features of ALS. 2012 International Federation of Clinical Neurophysiology.

Outcomes following inpatient rehabilitation of lower limb amputees

Introduction: Lower-limb amputations are a serious adverse consequence of lifestyle related chronic conditions and a serious concern among the aging population in Australia. Lower limb amputations have severe personal, social and economic impacts on the individual, healthcare system and broader community. This study aimed to address a critical gap in the research literature by investigating the physical functioning and social characteristics of lower limb amputees at discharge from tertiary hospital inpatient rehabilitation. Method: A cohort study was implemented among patients with lower limb amputations admitted to a Geriatric Assessment and Rehabilitation Unit for rehabilitation at a tertiary hospital. Conventional descriptive statistics were used to examine patient demographic, physical functioning and social living outcomes recorded for patients admitted between 2005 and 2011. Results: A total of 423 admissions occurred during the study period, 313 (74%) were male. This sample included admissions for left (n = 189, 45%), right (n = 220, 52%) and bilateral (n = 14, 3%) lower limb amputations, with 15 (3%) patients dying whilst an inpatient. The mean (standard deviation) age was 65 (13.9) years. Amputations attributed to vascular causes accounted for 333 (78%) admissions; 65 (15%) of these had previously had an amputation. The mean (SD) length of stay in the rehabilitation unit was 56 (42) days. Prior to this admission, 123 (29%) patients were living alone, 289 (68%) were living with another and 3 (0.7%) were living in residential care. Following this amputation related admission, 89 (21%) patients did not return to their prior living situation. Of those admitted, 187 (44%) patients were discharged with a lower limb prosthesis. Conclusion: The clinical group is predominately older adults. The ratio of males to females was approximately 3:1. Over half did not return to walking and many were not able to return to their prior accommodation. However, few patients died during their admission.

Utility of an alternative bicycle commute route of lower proximity to motorised traffic in decreasing exposure to ultra-fine particles, respiratory symptoms and airway inflammation - a structured exposure experiment

Background: Bicycle commuting in an urban environment of high air pollution is known as a potential health risk, especially for susceptible individuals. While risk management strategies aimed to reduce motorised traffic emissions exposure have been suggested, limited studies have assessed the utility of such strategies in real-world circumstances. Objectives: The potential of reducing exposure to ultrafine particles (UFP; < 0.1 µm) during bicycle commuting by lowering interaction with motorised traffic was investigated with real-time air pollution and acute inflammatory measurements in healthy individuals using their typical, and an alternative to their typical, bicycle commute route. Methods: Thirty-five healthy adults (mean ± SD: age = 39 ± 11 yr; 29% female) each completed two return trips of their typical route (HIGH) and a pre-determined altered route of lower interaction with motorised traffic (LOW; determined by the proportion of on-road cycle paths). Particle number concentration (PNC) and diameter (PD) were monitored in real-time in-commute. Acute inflammatory indices of respiratory symptom incidence, lung function and spontaneous sputum (for inflammatory cell analyses) were collected immediately pre-commute, and one and three hours post-commute. Results: LOW resulted in a significant reduction in mean PNC (1.91 x e4 ± 0.93 x e4 ppcc vs. 2.95 x e4 ± 1.50 x e4 ppcc; p ≤ 0.001). Besides incidence of in-commute offensive odour detection (42 vs. 56 %; p = 0.019), incidence of dust and soot observation (33 vs. 47 %; p = 0.038) and nasopharyngeal irritation (31 vs. 41 %; p = 0.007), acute inflammatory indices were not significantly associated to in-commute PNC, nor were these indices reduced with LOW compared to HIGH. Conclusions: Exposure to PNC, and the incidence of offensive odour and nasopharyngeal irritation, can be significantly reduced when utilising a strategy of lowering interaction with motorised traffic whilst bicycle commuting, which may bring important benefits for both healthy and susceptible individuals.