Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.

Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus nephritis. Inbred mouse strains differ in susceptibility to anti-GBM antibody-induced and spontaneous lupus nephritis. This study sought to clarify the genetic and molecular factors that maybe responsible for enhanced immune-mediated renal disease in these models. When the kidneys of 3 mouse strains sensitive to anti-GBM antibody-induced nephritis were compared with those of 2 control strains using microarray analysis, one-fifth of the underexpressed genes belonged to the kallikrein gene family,which encodes serine esterases. Mouse strains that upregulated renal and urinary kallikreins exhibited less evidence of disease. Antagonizing the kallikrein pathway augmented disease, while agonists dampened the severity of anti-GBM antibody-induced nephritis. In addition, nephritis-sensitive mouse strains had kallikrein haplotypes that were distinct from those of control strains, including several regulatory polymorphisms,some of which were associated with functional consequences. Indeed, increased susceptibility to anti-GBM antibody-induced nephritis and spontaneous lupus nephritis was achieved by breeding mice with a genetic interval harboring the kallikrein genes onto a disease-resistant background. Finally, both human SLE and spontaneous lupus nephritis were found to be associated with kallikrein genes, particularly KLK1 and the KLK3 promoter, when DNA SNPs from independent cohorts of SLE patients and controls were compared. Collectively, these studies suggest that kallikreins are protective disease-associated genes in anti-GBM antibody-induced nephritis and lupus.

El oboe según Bach : estudio sobre la utilización del oboe en la obra de Johann Sebastian Bach

En este trabajo se relatan los acontecimientos que dieron pié a la relación simbiótica entre Johann Sebastian Bach y el oboe. Es un escrito de carácter divulgativo para el cual se consultaron tanto fuentes primarias como secundarias, las cuales se plasman aquí a manera de resumen. Como resultado de esta relación, nos ha llegado la colección más grande de música para oboe solista jamás escrita por un solo compositor.

4550. The beautiful Church of S. Sebastian, built of steel, Manila / [photogr. Underwood & Underwood]

Donateur : Vassal, Gabrielle Maud (1880-1959)

Elegie to Sebastian Knight

Soitinnus: sello.

Elegie to Sebastian Knight

Soitinnus: sello.

新刻才美巧相逢. 宛如約Xin ke cai mei qiao xiang feng. — Yuan ru yue.Rencontre du talent, de la beauté et de l'industrie : contrat de Yuan ru ; nouvelle édition.

Roman par Xi hua zhu ren. Gravé au Zui yue shan ju.4 livres (16 hui).

濟美篇Ji mei pian.

Vie de saint Louis de Gonzague.Par le P. Parrenin ; publié par les soins du P. Hinderer.3 livres.

夢美土記Meng mei tu ji.

Rêve du Paradis.Récit d'inspiration chrétienne (1707) par Wang Ruo han.9 feuillets.

Pequeña colección de rudimientos del canto llano para los niños que concurren a las escuelas parroquiales a quienes ofrece este humilde trabajo el actual cura parroco de San Sebastian

UANL

Decretum. Comm. Bartholomaeus Brixiensis et Johannes Semeca. et Sebastian Brant

Temas sobre derecho natural, positivo y divino ; Las fuentes del derecho canónico ; Temas jurídicos sobre los Obispos y el Clero ; Temas sobre la penitencia ; 33 Causas o Cuestiones sobre diversos temas: Cargos eclesiásticos, duración, simonía, herejía ; Distinciones explicaciones sobre diversos temas: consagración de iglesias, eucarística.

Johann Sebastian Bach y el gusto francés.

Resumen en inglés

La influencia del estilo italiano en la obra de Johann Sebastian Bach

Resumen basado en el de la publicación. Resumen en inglés