The history of the reformation of the Church of England /

v. 1. The first part: Of the progress made in the reformation during the reign of King Henry VIII.--v. 2. The second part: Of the progress made in the reformation till the settlement of it in the beginning of Queen Elizabeth's reign.--v. 3. The third part: Being a supplement to the two formerly published.--v. 4-5. A collection of records, letters, and original papers, with other instruments referred to in the first [and second] part[s] ... [Appendices] concerning some of the errors and falsehoods in Sanders' book of the English schism.--v. 6. A collection of records ... [etc.] referred to in the third part ... --v. 7. Editors preface. Corrigenda et addenda. Chronological index of records. General index.

History of the reformation of the Church of England. : In two parts. /

Mode of access: Internet.

Histoire du divorce de Henry VIII. Roy d'Angleterre, et de Catherine d'Arragon : avec la défense de Sanderus : la refutation des deux premiers livres de l'Histoire de la Reformation de M. Burnet : et les preuves.

"Epistre", t.1, signed: Joachim le Grand.

Diui Thomae Aquinatis ... In librum B. Iob expositio, cum indice rerum memorabilium.

CCPB,

De typica et honoraria sacrarum imaginum adoratione libri duo : quorum prior in adorandis Sanctorum Imaginibus nullum esse idolatriae periculum ... /

CCBE S. XVI, S, 385

Nimpharum oceani tidium, ephydridum potamidum, naiadum, lynadumque icones, ingratiam picturae studiosae ivventutis deliniatae scalptae (sic) et editae / Philip. Gallaeo

Collectionneur : Bégon, Michel (1638-1710)

[Evangelicae historiae imagines, ex ordine Evangeliorum, quae toto anno in Missae sacrificio recitantur, im ordinem temporis vitae Christae digestae /

Grabados con ilustraciones de las escenas de los evangelios. Firmas de: Anthoine Wiericx, Hieronymus Wiericx, Johan Wiericx, Karel van Marelly, Adriaen Collaert, Johan Collaert, Nicolás de Bruyn, Bernardino Passeri, Giovanni Battista de Benedetto Fiammeri, Martin de Vos.

The new Golden Legend: Patrick Nicholas's secular saints

The work of Italian-based photo-artist Patrick Nicholas is analysed to show how his re-workings of classic ‘old-master’ paintings can be seen as the art of ‘redaction,’ shedding new light on the relationship between originality and copying. I argue that redactional creativity is both highly productive of new meanings and a reinvention of the role of the medieval Golden Legend. (Lives of the Saints).

Integrated genomic characterization of endometrial carcinoma

We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.

Genetic studies of body mass index yield new insights for obesity biology

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10−8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ~2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Directional dominance on stature and cognition in diverse human populations

Homozygosity has long been associated with rare, often devastating, Mendelian disorders1, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3, 4. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10−300, 2.1 × 10−6, 2.5 × 10−10 and 1.8 × 10−10, respectively). In each case, increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months’ less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing evidence that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5, 6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.

Acerca del Troço de la corónica del rey don Enrique el Doliente del manuscrito BNM 1530

Resumen: A raíz del descubrimiento de un testimonio desconocido perteneciente a la tradición de la Refundición del Sumario del Despensero, en ff. 238v-239v del manuscrito Biblioteca Nacional de España 15530 (BETA manid 4978), la ponencia se propone indagar el procedimiento fragmentario de construcción del objeto historiable en las obras historiográficas del siglo XV conocidas como sumarios de crónicas. Del mismo modo, vincula este fragmento con los hechos narrados en el “Magnicidio de Alfaro” (Crónica de Sancho IV) proponiendo su inclusión dentro del tópico “prendimiento de un grande”, el cual encuentra significativos ejemplos en la cronística medieval española.

Dialogos de Dom Frei Amador Arraiz Bispo de Portalegre

Frei Amador Arrais nasceu em Beja, Portugal, por volta de 1530, e morreu em Coimbra, em 1600. Celebrizou-se como orador sacro e, em 1581, foi designado para o bispado de Portalegre. Em 1589, publicou os ‘Dialogos’. No primeiro deles trata ‘Das queixas dos enfermos, e da Cura dos médicos’; no segundo, ‘Da gente judaica’; no terceiro, ‘Da gloria e triumpho dos lusitanos’; no quarto, ‘Das condições do bom principe’ e ‘Da consolação para hora da morte’; no quinto, ‘Da paciencia e fortaleza christam’; no sexto, ‘Do testamento christão’; no sétimo, ‘Da invocação de Nossa Senhora’. Existem três edições, sendo a segunda também de Coimbra, de 1604, e a terceira de Lisboa, de 1846. Segundo Inocêncio, "tanto a primeira como a segunda edição foram sempre procuradas, e tidas na conta de raras, desde muitos anos, mormente a segunda, que era e é ainda a preferida". Frei Amador Arrais é um dos representantes da "prosa mística", estudada por Fidelino de Figueiredo na sua ‘História de literatura clássica’. Para ele, há, em Amador Arrais, "a par do fervoroso sentimento religioso, que a seu serviço pôs a pena do escritor. maior observação da vida e do seu tempo, mesmo certo fundo de bom senso, revelado principalmente na diálogo sobre as qualidades morais que deve ter um bom príncipe".

"Nortia, te veneror" (CLE 1530 = CIL 6. 537): la defensa de Avieno de la fortuna y del encomio propio

Este trabajo ha sido realizado dentro del Grupo de Investigación GIU 10-19 “LITTERARVM. Grupo de Investigación en Literatura, Retórica y Tradición Clásica” de la UPV/EHU.