999 resultados para Saint Bernard dog


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"Part II: General care and training of your dog, by Elsworth S. Howell, Milo G. Denlinger [and] A. C. Merrick."

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Quincye "Mss bibliothec. du marquis de Quincy venant de Mr Fevret de Fontette...", "Donné par le marquis de Quincy aux manuscrits du roy" (1); cf. B.n.F., Imprimés, D 5373, ex dono "Donné à la bibliotheque du roy 1770, le marquis de Quincye"

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An inherited polyneuropathy (PN) observed in Leonberger dogs has clinical similarities to a genetically heterogeneous group of peripheral neuropathies termed Charcot-Marie-Tooth (CMT) disease in humans. The Leonberger disorder is a severe, juvenile-onset, chronic, progressive, and mixed PN, characterized by exercise intolerance, gait abnormalities and muscle atrophy of the pelvic limbs, as well as inspiratory stridor and dyspnea. We mapped a PN locus in Leonbergers to a 250 kb region on canine chromosome 16 (Praw = 1.16×10-10, Pgenome, corrected = 0.006) utilizing a high-density SNP array. Within this interval is the ARHGEF10 gene, a member of the rho family of GTPases known to be involved in neuronal growth and axonal migration, and implicated in human hypomyelination. ARHGEF10 sequencing identified a 10 bp deletion in affected dogs that removes four nucleotides from the 3'-end of exon 17 and six nucleotides from the 5'-end of intron 17 (c.1955_1958+6delCACGGTGAGC). This eliminates the 3'-splice junction of exon 17, creates an alternate splice site immediately downstream in which the processed mRNA contains a frame shift, and generates a premature stop codon predicted to truncate approximately 50% of the protein. Homozygosity for the deletion was highly associated with the severe juvenile-onset PN phenotype in both Leonberger and Saint Bernard dogs. The overall clinical picture of PN in these breeds, and the effects of sex and heterozygosity of the ARHGEF10 deletion, are less clear due to the likely presence of other forms of PN with variable ages of onset and severity of clinical signs. This is the first documented severe polyneuropathy associated with a mutation in ARHGEF10 in any species.

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Mode of access: Internet.

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Antep.

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Includes index.

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Based on the edition of Jacob Merler, 1641.

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Mode of access: Internet.

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Contient : 1° « Traittié de felicité de vie », par « CHARLES SOILLOT », prose et vers ; 2° « Les sept Joyes Nostre Dame » [par CHARLES SOILLOT] ; 3° « L'Epitre saint BERNARD, de la regle et maniere comment le mesnage d'un bon hostel doit estre prouffitamment gouverné... translatée de latin en cler françois par JOHANNES MIELOT, prestre indigne, chanoine de l'eglise Saint Pierre de Lille en Flandres »

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Contient : 1° « Le Livre de l'Ordre de chevalerie » ; 2° Épître à Alexandre ; 3° « Epitre que saint BERNARD envoya à Raimont, seigneur du Chastel Saint Ambroise »