Armas y blasones de las casas de Alaban de Ronffancoll, Rocafort y del Pozo, pertenecientes al Señor D.D. Juan José Mariano Alaban... Barón del Pozo y de Ronffancoll : Rocafort, año 1808

Enc. piel con hierros dorados

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

Background: None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for these failures may have been suboptimal T cell immunogen designs. Methods: To overcome this problem, we used a novel immunogen design approach that is based on functional T cell response data from more than 1,000 HIV-1 clade B and C infected individuals and which aims to direct the T cell response to the most vulnerable sites of HIV-1. Results: Our approach identified 16 regions in Gag, Pol, Vif and Nef that were relatively conserved and predominantly targeted by individuals with reduced viral loads. These regions formed the basis of the HIVACAT T-cell Immunogen (HTI) sequence which is 529 amino acids in length, includes more than 50 optimally defined CD4+ and CD8+ T-cell epitopes restricted by a wide range of HLA class I and II molecules and covers viral sites where mutations led to a dramatic reduction in viral replicative fitness. In both, C57BL/6 mice and Indian rhesus macaques immunized with an HTI-expressing DNA plasmid (DNA.HTI) induced broad and balanced T-cell responses to several segments within Gag, Pol, and Vif. DNA.HTI induced robust CD4+ and CD8+ T cell responses that were increased by a booster vaccination using modified virus Ankara (MVA.HTI), expanding the DNA.HTI induced response to up to 3.2% IFN-γ T-cells in macaques. HTI-specific T cells showed a central and effector memory phenotype with a significant fraction of the IFN-γ+ CD8+ T cells being Granzyme B+ and able to degranulate (CD107a+). Conclusions: These data demonstrate the immunogenicity of a novel HIV-1 T cell vaccine concept that induced broadly balanced responses to vulnerable sites of HIV-1 while avoiding the induction of responses to potential decoy targets that may divert effective T-cell responses towards variable and less protective viral determinants.

Simplifying data acquisition in plant canopies- Measurements of leaf angles with a cell phone

1. Canopies are complex multilayered structures comprising individual plant crowns exposing a multifaceted surface area to sunlight. Foliage arrangement and properties are the main mediators of canopy functions. The leaves act as light traps whose exposure to sunlight varies with time of the day, date and latitude in a trade-off between photosynthetic light harvesting and excessive or photoinhibitory light avoidance. To date, ecological research based upon leaf sampling has been limited by the available echnology, with which data acquisition becomes labour intensive and time-consuming, given the verwhelming number of leaves involved. 2. In the present study, our goal involved developing a tool capable of easuring a sufficient number of leaves to enable analysis of leaf populations, tree crowns and canopies.We specifically tested whether a cell phone working as a 3Dpointer could yield reliable, repeatable and valid leaf anglemeasurements with a simple gesture. We evaluated the accuracy of this method under controlled conditions, using a 3D digitizer, and we compared performance in the field with the methods commonly used. We presented an equation to estimate the potential proportion of the leaf exposed to direct sunlight (SAL) at any given time and compared the results with those obtained bymeans of a graphicalmethod. 3. We found a strong and highly significant correlation between the graphical methods and the equation presented. The calibration process showed a strong correlation between the results derived from the two methods with amean relative difference below 10%. Themean relative difference in calculation of instantaneous exposure was below 5%. Our device performed equally well in diverse locations, in which we characterized over 700 leaves in a single day. 4. The newmethod, involving the use of a cell phone, ismuchmore effective than the traditionalmethods or digitizers when the goal is to scale up from leaf position to performance of leaf populations, tree crowns or canopies. Our methodology constitutes an affordable and valuable tool within which to frame a wide range of ecological hypotheses and to support canopy modelling approaches.

Tratado de la distribución de las aguas del río Turia, y del Tribunal de los Acequieros de la Huerta de Valencia

Incluye grab. en p. 1 y p.143: "Grabado por Tomas Rocafort en Valª 1831"

Dissertacion critica de la certidumbre del cuerpo de S. Marcia M., noble matrona romana : venerado en el colegio de S. Joaquin de la Escuela Pia de Valencia

Sign.: A-B8, C3

Dissertacion critica, de la certidumbre del cuerpo de S. Marcia M., noble matrona romana : Venerado en el Colegio de S. Joaquin de la Escuela Pia de Valencia

Hay un ejemplar encuadernado con: Rondalla de Rondalles a imitació del cuento de cuentos de Don Francisco de Quevedo y de la historia de histories de Don Diego de Torres (XVI/378).

Esplicacion del trono en que se manifiesta el SS. Sacramento en la exposicion solemne de cuarenta horas de la parroquia de los Santos Juanes : año 1828

Grab. calc.: "Lamina que manifiesta el Trono del SS. Sacramento en las horas de la Iglesia de los Stos. Juanes de Valencia a[ño] 1828 ; grabado por Rocafort en Val.a"

[Ordenanzas reales]

Sign.: []1, 1-12(2), 13(3)

Compendio del feliz hallazgo de la milagrosissima imagen de la Virgen de Aguas Vivas : con alguna reflexion de sus notables circunstancias, y recopilacion de algunos Milagros...

Fecha tomada de colofón

San Vicente Ferrer [Material gráfico]

Descripción: Retrato de cuerpo entero de San Vicente Ferrer el cual sustenta una cruz en la mano der. y con la izq. señala al cielo

Los romanos son expulsos [sic] de España por el Rey Suinthila [Material gráfico]

Inscripción en la parte superior: "Lamª 34. Tomº 2º. Pagº 24"

Boileau [Material gráfico] : el Horacio francés

Plancha de acero