Office of Sponsored Research Administration Report Through February 2009

This is a semi-annual report to the Board of Trustees.

Office of Sponsored Research Administration Fiscal Year 2008-2009 Report

This document consists of the Fiscal Year 2008-2009 (FY 2009) report to the Board of Trustees (BOT).

Research and University Graduate School Report; Office of Sponsored Research Administration - Fiscal Year 2007-2008

The Office of Sponsored Research Administration became The Division of Research. The Division of Research became the Office of Research and Economic Development in January 2015.

Office of Sponsored Research Administration Report, September 10, 2007

The report includes details of the externally funded sponsored activity managed by OSRA for fiscal years 2006 and 2007.

Administration of Il-18bp by Gene Therapy Reduces Inflammation and Prevents Joint Destruction by Downregulation of Mmp9 In Rat Aia: Role ff Mmp9 In Bone and Joint Destruction in Arthritis

Background and objectives Interleukin 18 (IL-18) is a pleiotropic cytokine involved in rheumatoid arthritis (RA) pathogenesis. This study was carried out to evaluate the effi cacy of IL-18 binding protein (IL-18BP) gene therapy in the rat adjuvant- induced arthritis (AIA) model and to decipher the mechanisms by which IL-18BP delivery lessens bone destruction.Materials and methods Arthritis was induced in female Lewis rat by Mycobacterium butyricum and the mRNA expression of IL-18 and IL-18BP was determined in the joints. In a preventive study, rats were divided into an adenovirus producing IL-18BP-Fc (AdmIL-18BP-Fc) group (n=8) and an adenovirus producing green fl uorescent protein (AdGFP) group (n=7). On day 8 after AIA induction, adenoviruses were injected. Clinical parameters were assessed. At day 18, during maximal arthritis, the rats were euthanized, ankles were collected and x-rays were performed. mRNA and protein were extracted from joints for analysis by quantitative reverse transcriptase-PCR, multiplex, Western blot and zymography.Results The authors observed a decrease in the (IL-18BP/ IL-18) ratio from day 7 to 45. Administration of AdmIL-18BPd-Fc decreased clinical parameters and prevented bone and joint destruction compared to AdGFP administration. IL-18BP delivery reduced the (receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG)) ratio by 70%, the matrix metalloproteinase 9 (MMP9) level by 33% and the tartrate-resistant acid phosphatase (TRAP) level by 44% in the joint homogenates from AdmIL-18BPd-Fc compared to AdGFP treated rats.Conclusions In rat AIA, a decrease in the (IL-18BP/IL-18) ratio was observed. IL-18BP delivery prevented joint and bone destruction by downregulating MMP9, (RANKL/OPG) and TRAP, suggesting a potential benefi t of a similar therapy in RA.Abstract topics Towards novel therapeutic strategies.

Research and related services in the United States Department of Agriculture : prepared for the Committee on Agriculture of the House of Representatives, Eighty-first Congress, second session. Dec. 21, 1950.

At head of title: Committee print.

Report of the administrator of agricultural research,

Includes the reports of the following agencies of the administration: the Bureaus of Agricultural and industrial chemistry; Animal industry; Dairy industry; Entomology and plant quarantine; Human nutrition and home economics; Plant industry, soils, and agricultural engineering; and the Office of experiment stations.

The Agricultural Research Center of the United States Department of Agriculture; an account of activities at the Department's largest research station, at Beltsville, Md.

Cover title.

An investigation of the exact solutions of the linearized equations for the flow past conical bodies,

Reproduced from type-written copy.

Some refrigeration tests of a motor truck-trailer equipped with one type of dry ice system of refrigeration. (An interim report)

Mode of access: Internet.

E /

Description based on: [No.] 307 (June 1933); title from caption.

Report of the chief of the Bureau of Home Economics.

Title from caption.

A study of the effect of ionizing radiation on resistance, germination, and toxin synthesis of Clostridium botulinum spores, types A, B, and E

At head of title: The University of Michigan, College of Engineering, Dept. of Chemical and Metallurgical Engineering. Final report.

Rural family spending and saving in wartime.

"Published as a part of the Study of family spending and saving in wartime, conducted by the Bureau of Human Nutrition and Home Economics, Agricultural Research Administration, in cooperation with the United States Bureau of Labor Statistics."

Family food consumption in the United States, spring 1942.

"Published as a part of the Study of family spending and saving in wartime, conducted by the Bureau of Human Nurition and Home Economics, Agricultural Research Administration, in cooperation with the United States Bureau of Labor Statistics."