Total Synthesis of the Potent HIF-1 Inhibitory Antitumor Natural Product, (8R)-Mycothiazole, via Baldwin–Lee CsF/CuI sp3–sp2-Stille Cross-Coupling. Confirmation of the Crews Reassignment

A convenient asymmetric total synthesis of the potent HIF-1 inhibitory antitumor natural product, (−)- or (+)-(8R)-mycothiazole (1), is described. Not only does our synthesis confirm the 2006 structural reassignment made by Crews (Crews, P., et al. J. Nat. Prod. 2006, 69, 145), it revises the [α]_D data previously reported for this molecule in MeOH from −13.7° to +42.3°. The newly developed route to (8R)-1 sets the C(8)–OH stereocenter via Sharpless AE/2,3-epoxy alcohol reductive ring opening and utilizes two Baldwin–Lee CsF/cat. CuI Stille cross-coupling reactions with vinylstannanes 8 and 3 to efficiently elaborate the C(1)–C(4) and C(14)–C(18) sectors.

Aḥkam at-tārīḵẖ: al-maʻrūf, Maḥbūb as-salāt̤īn

Muḥammad Ḥusayn Ḵẖān Ṣāḥib.

Superconducting Transition-Edge Sensor Physics

Despite record-setting performance demonstrated by superconducting Transition Edge Sensors (TESs) and growing utilization of the technology, a theoretical model of the physics governing TES devices superconducting phase transition has proven elusive. Earlier attempts to describe TESs assumed them to be uniform superconductors. Sadleir et al. 2010 shows that TESs are weak links and that the superconducting order parameter strength has significant spatial variation. Measurements are presented of the temperature T and magnetic field B dependence of the critical current Ic measured over 7 orders of magnitude on square Mo/Au bilayers ranging in length from 8 to 290 microns. We find our measurements have a natural explanation in terms of a spatially varying order parameter that is enhanced in proximity to the higher transition temperature superconducting leads (the longitudinal proximity effect) and suppressed in proximity to the added normal metal structures (the lateral inverse proximity effect). These in-plane proximity effects and scaling relations are observed over unprecedentedly long lengths (in excess of 1000 times the mean free path) and explained in terms of a Ginzburg-Landau model. Our low temperature Ic(B) measurements are found to agree with a general derivation of a superconducting strip with an edge or geometric barrier to vortex entry and we also derive two conditions that lead to Ic rectification. At high temperatures the Ic(B) exhibits distinct Josephson effect behavior over long length scales and following functional dependences not previously reported. We also investigate how film stress changes the transition, explain some transition features in terms of a nonequilibrium superconductivity effect, and show that our measurements of the resistive transition are not consistent with a percolating resistor network model.

Khulāṣah-ʼi qavānīn kih az ḥuz̤ūr-i gūrnar Janral Bahādur nisbat bih ṣawbahʹjāt-i Bankālah va Bihār Awrīsah dar bāb-i har ṭūr-i maḥṣūl va tijārat

Translation into Persian.

Kitāb-i ashʻār-i malik al-shuʻārāʼ Amīr Muʻizzī : manuscript, 1156

Title from f. 1r.

Ḥāshiyah-ʼi Nawwāb-i marḥūm-i maghfūr Khalīfah Sulṭān bar Maʻālim al-uṣūl : manuscript

1853 or 4.

Kitāb iḥyāʾ al-qulūb sharḥ al-imām al-ʻārif billāh taʻālah ʻUmdat al-wāṣilīn wa-kaʻbat al-sālikīn yanbūʻ ʻilm al-ḥaqīqah wa-al-dīn mawlānā al-Shaykh ʻAbd al-Qādir al-Rāfiʻī al-Fārūqī al-Ṭarābulusī ʻalá ḥukum shaykhihi waliya Allāh ṣāḥib al-karāmāt al-ḍhāhirah wa-al-ishārāt al-bāhirah Sayyidī Maḥmūd al-Khallūtī.

Mode of access: Internet.

Kitāb-i mustatāb-i tarjumah-ʾi Tārīkh-i Yamīnī [microform] /

Translated into Persian by N⁻asih ibn-Zafar al-Jarb⁻adhaq⁻ani.

A catalogue of an exhibition of angling book plates : forming the collection of Daniel B. Fearing, Newport, R.I.

Cover title: A catalogue of angling book plates forming the collection of Daniel B. Fearing, Newport, R.I.

Kitāb-i Nuqṭat al-kāf : dar tārīkh-i ẓuhūr-i Bāb va vaqāyiʻ-i hasht sāl-i avval az tārīkh-i Bābīyah /

Includes index.

The life and architectural works of William Henman, F.R.I.B.A.

DUE TO COPYRIGHT RESTRICTIONS ONLY AVAILABLE FOR CONSULTATION AT ASTON UNIVERSITY LIBRARY AND INFORMATION SERVICES WITH PRIOR ARRANGEMENT

Relativistic radiatively damped R -matrix calculations of the electron-impact excitation of helium-like iron and krypton

Electron-impact excitation data for He-like ions are of significant importance for diagnostic applications to both laboratory and astrophysical plasmas. Here we report on the first fully relativistic R -matrix calculations with radiation damping for the He-like ions Fe 24+ and Kr 34+ . Effective collision strengths for these two ions have been determined with and without damping over a wide temperature range for all transitions between the 49 levels through n = 5. We find that damping has a pronounced effect on the effective collision strengths for excitation to some of the low-lying levels, but its effect on excitation to the vast majority of levels is small. At the energy of a resonance peak, we also investigate the effect of radiation damping on the angular distribution of scattered electrons. Finally, we compare our results for Fe 24+ with an earlier intermediate coupling frame transformation R -matrix calculation with radiation damping by Whiteford et al ( J. Phys. B: At. Mol. Opt. Phys. 34 3179) and find good agreement, especially for excitation to the lower levels.

Programación de las ciencias naturales de 3õ de bachillerato : una experiencia realizada por el seminario del I.N.B. 'Calderón de la Barca' de Madrid.

La asignatura de Ciencias Naturales de 3õ BUP optativa con cuatro horas lectivas sigue un programa que consideramos, en cierto modo, incoherente para el nivel de los alumnos. Se mezclan en el tres tipos de materias dispares: Anatomía, Fisiología Humana, Anatomía y Fisiología de las plantas y algunos temas incoherentes de Geología. Este programa es un ejemplo que plantea la necesidad de una reordenación de los programas de esta materia. En conjunto uniformes, con una separación de las distintas materias de esta asignatura en los distintos cursos. Sería útil mantener la asignatura en los tres cursos con tres horas semanales; Un primer curso de zoología y botánica y microbiología descriptiva; un segundo, de geología básica, ecología y evolución paleontológica; un tercero, de biología general y anatomía y fisiología humanas. El temario oficial lo dividimos en cinco partes para coincidir con las evaluaciones. 1. Química e Histología animal. 2. Funciones de nutrición. 3. Funciones de relación y reproducción. 4. Geología. 5. Botánica.