D. Iasonis Pratensis... de Cerebri morbis : hoc est, omnibus fermè (quoniam à cerebro male affecto omnes ferè qui corpus humanum infestant, morbi oriuntur) curandis Liber ... : secundùm veterum Graecorum, Latinorum, & Arabum, necnon recentium praecepta ...

Mode of access: Internet.

Epicrisis critico-apologetica de affectu atrabilario, mirachiali sive de morbis cerebri, et mentis, qui extra cerebrum originem ducunt /

Mode of access: Internet.

Bartholomaei de Moor veris oeconomiae animalis, seu potius humanae, principiis innixae pathologiae cerebri delineatio practica : in qua, morborum soporosorum, per notas characteristicas, distinctio nec non spasmorum accuratior distributio traditur.

Mode of access: Internet.

Francisci Josephi Burrhi Epistolæ duæ. I. De cerebri ortu [et] usu medico. II. De artificio oculorum humores restituendi. Ad. Th. Bartholinum.

Mode of access: Internet.

Vir. Clariss. Casp. Hofmannvs de usu lienis. cerebri et de ichoribvs.

Grabado calcográfico en la portada, en el que aparece, además, el retrato del autor.

Anatomicarum annotationum, liber secundus : de organo olfactus praecipuo deque nervis nasalibus interioribus e pari quinto nervorum cerebri /

Mode of access: Internet.

Insufficientia cerebri, ad sensum & motum animalis expenditur meningumque ad illos indispensabilior usus assertus, adversus vagas intentationes Joh.Philip. Burggravii ... stabilitur a J.D. Gohl.

Mode of access: Internet.

Raymundi Vieussens doctoris medici monspeliensis Neurographia universalis, hoc est Omnium corporis humani nervorum, simul et cerebri, medullae que spinalis descriptio anatomica : eaque integra [et] accurata, variis iconibus fideliter [et] ad vivum delineatis, aereque incisis illustrata, cum ipsorum actione [et] usu, physico discursu explicatis.

Mode of access: Internet.

Joannis Georgii Michaeliis ... Observationes sacrae : in quibus diversis Sacrae Scripturae utriusque golderis locis selectioribus ex linguae ebraeae ... Exercitatio de sacrificio cordis et cerebri ...

Mode of access: Internet.

Henrici Ridley ... Anatomia cerebri complectens : ejus mechanismum [et] physiologiam, simulque nova quædam inventa, cum correctionibus aliquod veterum ac recentiorum, qui in eandem materiam scripserunt. Cui annexum est examen accuratum functionum animalium et motus muscularis. Omnia elegantibus ad vivum expressis sculpturis illustrata, ex Anglico in Latinum fidelitur translata.

Mode of access: Internet.

Estudo tomográfico encefálico de felinos hígidos adultos e idosos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Gorlin syndrome: Importance of clinical signs and danger of delayed diagnosis A case report with eight years follow-up

Nevoid basal cell carcinoma (NBCCS) or Gorlin-Goltz syndrome (GS) is a multidisciplinary problem, the early diagnosis of which allows secondary prophylaxis that follows an appropriate regimen to delay progression of the syndrome. The aim of this study was to present a case of delayed diagnosis of GS in a young patient who received multidisciplinary treatment 5 years after onset. The patient presented for evaluation with painless swelling of the left maxilla. Histological examination confirmed the diagnosis of a keratocyst odontogenic tumor (KOT) that was enucleated. On presentation, the patient’s symptoms and clinical signs were not related to complications of GS, and the possibility of GS was initially rejected, as he did not have a family history of the syndrome. Four years after the first surgery to remove the lesion, the patient came to our clinic with a brown, pigmented lesion. Computed tomography revealed ectopic lamellar calcification of the falx cerebri, which was the conclusive factor for the diagnosis of GS. It is important that clinicians recognize the clinical signs of GS, which mainly manifests itself as multiple basal cell carcinomas in the skin.

Pancreatic hemangioma manifesting as variceal gastroesophageal bleeding during pregnancy: case report

There are only 10 reported cases of pancreatic hemangiomas in adults, only one of them causing digestive bleeding. We present a case of variceal bleeding and portal hypertension caused by a pancreatic hemangioma. The patient had 19 year-old and was received at her 16th week of pregnancy. She had massive hematemesis, controlled after variceal band ligation. Her image exams revealed a cystic lesion of 164 cm³ in the pancreas tail and signs of portal hypertension. Two months after, the ultrassonographic exam documented the lesion growth, achieving 200 cm³ at that time. The patient was submitted to distal pancreatectomy, and the histopathological analysis revealed a pancreatic hemangioma of 11 x 9 x 8 cm. Therefore, we report the second case of digestive bleeding caused by a pancreatic hemangioma, which had a well documented growth during the pregnancy. Additionally, we review the previous reports of pancreatic hemangiomas and discuss the hypothesis of hormonal infl uence on the natural history of these tumors.

Cochleovestibular nerve involvement in multifocal fibrosclerosis

Objectives: To report a case of multifocal fibrosclerosis with a nine-year follow up, and to discuss this disease's radiological appearance and management. The disease is a rare systemic disorder of unknown cause characterised by fibrous proliferation involving multiple anatomical sites. Case report: A 50-year-old woman presented with histological findings characterised by similar inflammatory processes involving the meninges, pituitary gland, peritoneum, retroperitoneum and orbits, prompting a search for a common pathophysiology. A diagnosis of multifocal fibrosclerosis was postulated. Symptom improvement was noted after treatment with prednisone and azathioprine. Conclusion: This is the first documented case of involvement of the cochleovestibular nerve in a patient with multifocal fibrosclerosis. The rare association between fibrotic diseases and masses showing various clinical patterns should be kept in mind by otolaryngologists, and imaging performed to investigate for multifocal fibrosclerosis. However, diagnosis can only be confirmed with tissue biopsy and histopathological examination.

Meningial perineurioma: a benign peripheral nerve sheath tumor in a previously unrecognized central nervous system location, mimicking meningioma

Perineurioma is an uncommon, mostly benign, spindle-cell tumor of peripheral nerve sheath origin with a predilection for the soft tissues. Although increasing awareness points to the sites of involvement by perineurioma possibly being as ubiquitous as those frequented by schwannian tumors, only one intracerebral example has been described to date. We report on a surgically resected perineurioma of the falx cerebri in an 86-year-old woman. Preoperative imaging showed an enhancing extraaxial mass of 6 cm × 5.7 cm × 3.7 cm. Histologically, the tumor consisted of a proliferation of spindle cells interwoven by a lattice of basal lamina. Alongside a prevailing soft tissue perineurioma pattern, sclerosing and reticular areas were seen as well. Tumor cells coexpressed EMA and GLUT-1, and a minority immunoreacted for smooth muscle actin. Pericellular basal lamina was decorated with collagen type IV. No staining for S100 protein was detected. Mitotic activity was virtually absent, and the MIB1 labeling index averaged 2%. Ultrastructural examination revealed abundant pinocytotic vesicles within and conspicuous tight junctions between slender cytoplasmic processes which, in turn, were encased by discontinuous basal lamina. FISH analysis confirmed loss of at least part of one chromosome 22q. This observation calls attention to perineurioma as a novel item in the repertoire of low-grade meningial spindle cell neoplasms, in the differential diagnostic context of which it is apt to being misconstrued as either meningioma, solitary fibrous tumor, or neurofibroma. Confusion with the latter bears the risk of overgrading innocuous features of perineurioma as criteria for malignancy.