The poetical works of Matthew Prior.

Life of the author (v.1, p. [v]-xxviii) by Samuel Humphreys.

NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors

Skeletal muscle tissue undergoes adaptive changes in response to stress and the genes that control these processes are incompletely characterised. NDRG2 (N-myc downstream-regulated gene 2), a stress- and growth-related gene, was investigated in skeletal muscle growth and adaption. While NDRG2 expression levels were found to be up-regulated in both differentiated human and mouse myotubes compared with undifferentiated myoblasts, the suppression of NDRG2 in C2C12 myoblasts resulted in slowed myoblast proliferation. The increased expression levels of the cell cycle inhibitors, p21 Waf1/Cip1 and p27 Kip1, and of various muscle differentiation markers in NDRG2-deficient myoblasts indicate that a lack of NDRG2 promoted cell cycle exiting and the onset of myogenesis. Furthermore, the analysis of NDRG2 regulation in C2C12 myotubes treated with catabolic and anabolic agents and in skeletal muscle from human subjects following resistance exercise training revealed NDRG2 gene expression to be down-regulated during hypertrophic conditions, and conversely, up-regulated during muscle atrophy. Together, these data demonstrate that NDRG2 expression is highly responsive to different stress conditions in skeletal muscle and suggest that the level of NDRG2 expression may be critical to myoblast growth and differentiation.

AHI1 and NDRG2 function in skeletal muscle and the development of type 2 diabetes

In this study, AHI1 and NDRG2 gene function in the insulin signalling pathways regulating skeletal muscle homeostasis was investigated. Findings implicate AHI1 in the regulation of insulin-stimulated glucose transport and the development of insulin resistance, whilst associating NDRG2 with the regulation of myoblast proliferation and differentiation; possible via interactions with PICK1 and arfaptin2.

The works of the English poets /

Mode of access: Internet.

The works of the English poets /

Mode of access: Internet.

Prefaces biographical and critical, to the works of the english poets /

Mode of access: Internet.

Der Einfluss der englischen, französischen,

"Bibliographie": p. [v]-viii.

Transactions.

Includes bibliographies: A bibliography of John Evelyn, by H. B. Wheatley: v.1, 77-90 -- Incunabula Virgiliana, comp. by W. A. Copinger: v.2, p.[123]-226. A list of books and papers on printers and printing, under the countries and towns to which they refer. Comp. by T. B. Reed: v.3, p.[81]-152 -- List of manuscripts and examples of metal and ivory bindings from the Bibliotheca Lindesiana: v.4. p.[213]-232 -- Bibliography of printing in Sicily, by R. S. Faber: v.5, p.209-211 -- A bibliography of the writings of Christopher Smart, with biographical references. By G. J. Gray: v.6, p.[269]-303 -- List of lace books, by E. F. Strange: v.7, p.219-246 -- Handlist of books in the library of the Bibliographical society: v.8, li p -- A bibliography of the Thoughts of Marcus Aurelius Antoninus, by J. W. Legg: v.10, p.[15]-81 -- The bibliography of Petronius, by S. Gaselee, with a Short-title handlist: v.10, p.[141]-233 -- A list of bibliographical books published since 1893. Comp. by R. A. Peddie: v.10, p.[235]-311 -- Richard Schilders and the English Puritans, by J. D. Wilson: v.11, p.[65]-134 -- The Schotts of Strassburg and their press, by S. H. Scott: v.11, p.[165]-188 -- Notes on English books printed abroad, 1525-48, by R. Steele: v.11, p.[189]-236 -- The romance of Amadis of Gaul, by H. Thomas: v.11, p.[251]-297 -- Notes on the bibliography of Pope, by G. A. Aitken: v.12, p.[113]-143 -- Road-books and itineraries bibliographically considered, by Sir H. G. Fordham: v.13, p.[29]-68 -- The Palmerin romances, by H. Thomas: v.13, p.[97]-144 -- Books on accountancy, 1494-1600, by C. Gordon: v.13, p.[145]-170 -- An agreement for bringing out the second Quignon breviary. Ed. by J.W. Legg: v. 13, p. [323]-348 -- Notes on the bibliography of Matthew Prior, by G. A. Aitken: v.14, p.[39]-68 -- The City printers [with partial list of titles of City official literature] by C. Welch: v.14, p.[175]-241.

Calendar of the manuscripts of the Marquis of Bath preserved at Longleat, Wiltshire /

Vols. 1 and 3 edited by J. J. Cartwright and J. M. Rigg; v. 2, by Mrs. S. C. Lomas; v. 4, by Marjorie Blatcher; v. 5, by G. Dyfnallt Owen.

Original letters from Richard Baxter, Matthew Prior, Lord Bolingbroke ... with biographical illustrations /

Mode of access: Internet.

Analysis of Cone-Beam CT using prior information

Treatment plans for conformal radiotherapy are based on an initial CT scan. The aim is to deliver the prescribed dose to the tumour, while minimising exposure to nearby organs. Recent advances make it possible to also obtain a Cone-Beam CT (CBCT) scan, once the patient has been positioned for treatment. A statistical model will be developed to compare these CBCT scans with the initial CT scan. Changes in the size, shape and position of the tumour and organs will be detected and quantified. Some progress has already been made in segmentation of prostate CBCT scans [1],[2],[3]. However, none of the existing approaches have taken full advantage of the prior information that is available. The planning CT scan is expertly annotated with contours of the tumour and nearby sensitive objects. This data is specific to the individual patient and can be viewed as a snapshot of spatial information at a point in time. There is an abundance of studies in the radiotherapy literature that describe the amount of variation in the relevant organs between treatments. The findings from these studies can form a basis for estimating the degree of uncertainty. All of this information can be incorporated as an informative prior into a Bayesian statistical model. This model will be developed using scans of CT phantoms, which are objects with known geometry. Thus, the accuracy of the model can be evaluated objectively. This will also enable comparison between alternative models.