Popularização do autoexame da boca: um exemplo de educação não formal - Parte II

Um dos maiores desafios das universidades, em especial das públicas, é transpor o conhecimento científico produzido entre seus muros para a população em geral. A educação não formal é uma ferramenta importante e ainda pouco utilizada pelos pesquisadores e docentes para aproximar o cotidiano do conhecimento científico. O câncer de boca atinge mais 11.000 brasileiros por ano. A despeito da alta incidência, esta patologia é ainda pouco conhecida da população em geral e de parte da classe médica e odontológica. Baseando-se nos dados epidemiológicos, em pesquisas e artigos científicos, o câncer de boca foi o tema eleito para a ação em educação e comunicação da primeira campanha nacional, de caráter não governamental, de prevenção de câncer de boca, um ótimo exemplo de como isso pode ser feito. Este trabalho se propõe a descrever a metodologia de comunicação utilizada e os resultados obtidos nesta experiência.

Angiotensin II Binding to Angiotensin I-Converting Enzyme Triggers Calcium Signaling

Angiotensin (Ang) I-converting enzyme (ACE) is involved in the control of blood pressure by catalyzing the conversion of Ang I into the vasoconstrictor Ang II and degrading the vasodilator peptide bradykinin. Human ACE also functions as a signal transduction molecule, and the binding of ACE substrates or its inhibitors initiates a series of events. In this study, we examined whether Ang II could bind to ACE generating calcium signaling. Chinese hamster ovary cells transfected with an ACE expression vector reveal that Ang II is able to bind with high affinity to ACE in the absence of the Ang II type 1 and type 2 receptors and to activate intracellular signaling pathways, such as inositol 1,4,5-trisphosphate and calcium. These effects could be blocked by the ACE inhibitor, lisinopril. Calcium mobilization was specific for Ang II, because other ACE substrates or products, namely Ang 1-7, bradykinin, bradykinin 1-5, and N-acetyl-seryl-aspartyl-lysyl-proline, did not trigger this signaling pathway. Moreover, in Tm5, a mouse melanoma cell line endogenously expressing ACE but not Ang II type 1 or type 2 receptors, Ang II increased intracellular calcium and reactive oxygen species. In conclusion, we describe for the first time that Ang II can interact with ACE and evoke calcium and other signaling molecules in cells expressing only ACE. These findings uncover a new mechanism of Ang II action and have implications for the understanding of the renin-Ang system. (Hypertension. 2011;57:965-972.) . Online Data Supplement

Mn-II and Cu-II complexes with arylhydrazones of active methylene compounds as effective heterogeneous catalysts for solvent- and additive-free microwave-assisted peroxidative oxidation of alcohols

A one-pot template reaction of sodium 2-(2-(dicyanomethylene) hydrazinyl) benzenesulfonate (NaHL1) with water and manganese(II) acetate tetrahydrate led to the mononuclear complex [Mn(H2O)(6)](HL1a)(2)center dot 4H(2)O (1), where (HL1a) -= 2-(SO3-)C6H4(NH)=N=C(C N) (CONH2) is the carboxamide species derived from nucleophilic attack of water on a cyano group of (HL1) . The copper tetramer [Cu-4(H2O)(10)(-) (1 kappa N: kappa O-2: kappa O, 2 kappa N: k(O)-L-2)(2)]center dot 2H(2)O (2) was obtained from reaction of Cu(NO3)(2)center dot 2.5H(2)O with sodium 5-(2( 4,4-dimethyl-2,6-dioxocyclohexylidene) hydrazinyl)-4-hydroxybenzene-1,3-disulfonate (Na2H2L2). Both complexes were characterized by elemental analysis, IR spectroscopy, ESI-MS and single crystal X-ray diffraction. They exhibit a high catalytic activity for the solvent-and additive-free microwave (MW) assisted oxidation of primary and secondary alcohols with tert-butylhydroperoxide, leading to yields of the oxidized products up to 85.5% and TOFs up to 1.90 x 103 h(-1) after 1 h under low power (5-10 W) MW irradiation. Moreover, the heterogeneous catalysts are easily recovered and reused, at least for three consecutive cycles, maintaining 89% of the initial activity and a high selectivity.

Caracterização e análise da metodologia de desenho e estimação em inquérito por amostragem em Moçambique: uma aplicação prática ao Censo Agro-Pecuário 2009/10 (CAP II Moçambique) para pequenas explorações agrícolas

Dissertação apresentada como requisito parcial para obtenção do grau de Mestre em Estatística e Gestão de Informação

Résultats des campagnes scientifiques accomplies sur son yacht par Albert Ier, prince souverain de Monaco ...

fasc.45 [Spongiaires II] (1913)

Résultats des campagnes scientifiques accomplies sur son yacht par Albert Ier, prince souverain de Monaco ...

fasc.13 [Crustacés Décapodes II] (1899)

Résultats des campagnes scientifiques accomplies sur son yacht par Albert Ier, prince souverain de Monaco ...

fasc.37 [Mollusques II] (1912)

Le Clou de l'exposition de 1900 : notre musée des souverains n° IV, la Princesse Jolie-Mine : Wilhelmine : notre musée des souverains n° XI : [impression photomécanique] / Jean Veber

Collection : Le Rire ; 140

Recueil de lettres originales, mémoires, etc., concernant l'histoire de France. (XIVe-XVIe siècle). II.

On remarque dans le second volume la minute de lettres de Louis XI au Parlement de Paris, ordonnant d'instruire le procès de Louis de Luxembourg, comte de S. Pol (fol. 1) ; — des Instructions pour les ambassadeurs du roi de France auprès du roi de Sicile (fol. 5), — et de la seigneurie de Venise (fol. 12) ; — « Legatio explicita per.. Arnaudum de Yspania, Raymundum Bernardum Flamenchi et Johannem Foresii,... ambaxiatores per dominum ducem Andegavensem... ad dominos reges Castelle et Portugalie principaliter destinatos, » 1378 (fol. 16) ; — « Instruction baillée à Mons. Moreau de Wissant,... Pierre Rogier de Lyssac, et Thibaut Houe,... envoyéz par monseigneur d'Anjou au roy de Castille,.. » 1378 (fol. 32) ; — Articles sur lesquels on devait Interroger le duc de Nemours (fol. 42) ; — Mandements de François Ier et François II, 1538-1559 (fol. 44 et 73) ; — Mandements de Charles VIII et Louis XII, de Charlotte de Savoie et d'Anne de Beaujeu, 1486-1498 (fol. 53 et 79) ; — Lettres adressées au roi Charles VII par les ducs de Modène et de Milan, la seigneurie de Gênes, 1457-1459 (fol. 68) ; — Lettres de Bertrand Duguesclin au duc d'Anjou et au Roi (fol. 72, 126 et 162) ; — « Instructions de ce que le Roy veult et ordonne que messire Yvon du Fou face devers monsr de Briquebec et Guillaume de Valée, » 1468 (fol. 74) ; — Lettres de Charles d'Orléans au Roi, de Louis, duc d'Orléans, de Marguerite d'Écosse, dauphine de France, d'Anne de Bretagne, de Jeanne de France, fille de Louis XI, de Jean, duc de Bourbon, d'Arthur, comte de Richemont, d'Anne de France, dame de Beaujeu, de Madeleine, princesse de Vienne, 1483-1486 (fol. 76) ; — Lettres de François Ier, Henri II, Henri IV, Charles VIII, 1497-1591 (fol. 89) ; — Lettres de Charles d'Orléans au Roi, de François Ier, Charles VIII, Louis XII, etc., 1483-1538 (fol. 99) ; — Lettres adressées « à messieurs les gens des Comptes, » ou à Jacques Coictier, par Baudricourt, Louis de Graville, Philippe de Crèvecoeur, Éléonore d'Autriche, reine de France, Jean II, duc de Bourbon, René, duc de Lorraine et de Bar, « Jacques de Coitier, » Pierre, duc de Bourbonnais, Jean, bâtard d'Angoulême, Tristan de Salazar, archevêque de Sens, Guillaume et Robert Briçonnet, etc., 1464-1497 (fol. 127) ; — Lettres de Henri IV, Charles VIII, Louis XII, François Ier, Philippe le Beau, archiduc d'Autriche, Jean II, roi d'Aragon, Marguerite, duchesse d'Alençon, Charles, cardinal de Bourbon, Jacques Coitier, Pierre de Bourbon, sieur de Beaujeu, etc., 1457-1590 (fol. 163) ; — « Mémoire au seigneur de Lucé de faire les choses qui s'ensuivent » en Italie (fol. 201) ; — Suite du rapport envoyé à Louis XI par G. Cousinot ; cf. ms. 10237, fol. 126 (fol. 202) ; — Liste des châteaux de Catalogne, ayant été assiégés (fol. 216) ; — Lettre, en français, du pape Innocent VI à Jeanne d'Auvergne, reine de France (fol. 220).

[2 lettres d'Alice de Monaco à Jules Massenet, 1901-[1902]]

f. 3-4 : daté d'après le contenu