Memoir of William Madison Peyton, of Roanoke, together with some of his speeches in the House of delegates of Virginia, and his letters in reference to secession and the threatened civil war in the United States, etc., etc.

Appendixes: A. Abridged genealogy, or pedigree of the ancient noble family of Peyton: p. [311]-336; Isleham Hall, the priory and church, co. Cambridge, England: p. 337-354.--B. Memoranda of the Preston family, by O. Brown: p. [355]-374.--C. Abridged pedigree of the Lewis family: p. 375-379.--D. Extract from the Washington pedigree ... by John Washington: p. [380]-383.

Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-d-glucuronidase (heparanase)

Mammalian heparanase is an endo-β-glucuronidase associated with cell invasion in cancer metastasis, angiogenesis and inflammation. Heparanase cleaves heparan sulfate proteoglycans in the extracellular matrix and basement membrane, releasing heparin/heparan sulfate oligosaccharides of appreciable size. This in turn causes the release of growth factors, which accelerate tumor growth and metastasis. Heparanase has two glycosaminoglycan-binding domains; however, no three-dimensional structure information is available for human heparanase that can provide insights into how the two domains interact to degrade heparin fragments. We have constructed a new homology model of heparanase that takes into account the most recent structural and bioinformatics data available. Heparin analogs and glycosaminoglycan mimetics were computationally docked into the active site with energetically stable ring conformations and their interaction energies were compared. The resulting docked structures were used to propose a model for substrates and conformer selectivity based on the dimensions of the active site. The docking of substrates and inhibitors indicates the existence of a large binding site extending at least two saccharide units beyond the cleavage site (toward the nonreducing end) and at least three saccharides toward the reducing end (toward heparin-binding site 2). The docking of substrates suggests that heparanase recognizes the N-sulfated and O-sulfated glucosamines at subsite +1 and glucuronic acid at the cleavage site, whereas in the absence of 6-O-sulfation in glucosamine, glucuronic acid is docked at subsite +2. These findings will help us to focus on the rational design of heparanase-inhibiting molecules for anticancer drug development by targeting the two heparin/heparan sulfate recognition domains.

Missionary life among the cannibals : being the life of the Rev. John Geddie, D.D., first missionary to the New Hebrides : with a history of the Nova Scotia Presbyterian mission on that group / by George Patterson.

http://www.archive.org/details/cannibalmission00pattuoft

Photograph of Bell Family Relative [n.d.]

Small black and white photograph mounted on black card of an unidentified Bell family relative, possibly a sibling of Irene Bell, whose photo is similarly featured. This undated photograph was in the possession of the Rick Bell family, whose relatives include former Black slaves from the United States.According to the 1911 Census of Canada, Irene Bell had the following siblings: Ernest Bell, born 1889 Archie Bell, born 1895 Allen Bell, born 1901 Kenneth Bell, born 1910

Sloman Family Photo [n.d.]

This black and white photograph is believed to be of Albert Sloman (back left), Josephine Sloman (centre) and an unidentified man (right). Iris Sloman, daughter of Albert and Josephine, is thought to be in the front row, centre. The location and date of the photo is unknown, however, it could be in the early 1920s. This photograph was in the possession of Rick Bell, of St. Catharines, son of Iris and Richard Bell. Relatives of the Sloman - Bell family are former Black slaves from the United States.

A Life of John Colet, D.D. : dean of St. Paul's and founder of St. Paul's school ; with an appendix of some of his English writings /

Includes index.

The life of John Sharp, D.D., Lord Archbishop of York, to which are added, select original, and copies of original papers, in three appendixes, collected from his diary, letters, and several other authenic testimonies,

Mode of access: Internet.

Memoirs of the Rev. John McDowell, D.D., and the Rev. William A. McDowell, D.D.

Mode of access: Internet.

The works of John Donne, D.D., Dean of Saint Paul's, 1621-1631 : with a memoir of his life /

Contains selected sermons, letters and poems.

Memoirs of the life, writings, and religious connexions of John Owen, D. D., vice-chancellor of Oxford, and dean of Christ Church during the Commonwealth /

Mode of access: Internet.

Account of the life and writings of John Erskine, D.D., late one of the ministers of Edinburgh.

Mode of access: Internet.

The Hord family of Virginia; a supplement to the Genealogy of the Hord family,

Photocopy.

Recollections of the Rev. John McElhenney, D.D.,

Appendix: Sermon at the opening of Greenbrier Presbytery.--Semicentenary sermon.--Dr. M. L. Lacy's funeral discourse.

A master-builder on the Nile : being a record of the life and aims of John Hogg, D. D., Christian missionary /

Includes index.