202 resultados para PCT


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Ao falarmos de cidadania, pensamos num projecto de convivência, de pertença e participação plena numa comunidade humana, o que pressupõe uma dimensão social e política e acentua as capacidades de pensamento crítico e de agir consciente e intencional que permita salvaguardar o indivíduo na sua identidade e diversidade. Neste contexto, a Educação para a Cidadania é considerada um aspecto fundamental na educação integral de todos os alunos e está relacionada essencialmente com o desenvolvimento de competências de vida, pelo que as escolas e os professores de todas as áreas deverão assumi-la com significativo empenho, mantendo o propósito de assegurar que todos os conteúdos sejam efectivamente promovidos numa abordagem transdisciplinar, com implicações directas nas metodologias, no trabalho cooperativo, no planeamento curricular, nas práticas pedagógicas e na avaliação. Neste aspecto, o PCT permite que estas abordagens sejam efectivas e eficazes constituindo um óptimo auxiliador do trabalho docente. Foi com esta clara convicção que desenvolvemos o nosso estudo. O objecto em análise sugeriu a aplicação de metodologias de investigação de carácter qualitativo com uma posterior complementação mais quantitativa. Os processos aplicados na recolha de dados incluíram, numa primeira fase, a análise de alguns PCT no âmbito da educação para a cidadania no 1.º CEB e, posteriormente, a utilização de entrevistas semiestruturadas dirigidas aos docentes titulares de turma que colaboraram connosco neste trabalho. Os resultados da investigação permitiram-nos concluir que ainda existem muitos professores que têm dificuldade em operacionalizar a educação para a cidadania no PCT como área transversal, dificuldades que são extensivas à elaboração e concretização do referido documento. No entanto, os docentes são de opinião que o PCT constitui um óptimo recurso para o desenvolvimento de uma prática mais dinâmica e inovadora. A análise dos resultados sugere ainda maior aposta na formação de professores com vista ao esclarecimento e preparação destes profissionais na aplicação correcta dos novos documentos que vão surgindo a nível curricular, de forma a que as suas práticas possam constituir momentos de verdadeira inovação pedagógica condizentes com as pretensões de um novo paradigma educativo.

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Num mundo marcado pela globalização e mundialização dos problemas, um mundo igualmente em busca da preservação das raízes locais e identitárias, novas exigências se impõem à escola, no sentido de esta acompanhar as mudanças ocorridas e se adaptar às novas realidades. Uma adaptação que passa por soluções cada vez mais flexíveis e diferenciadas, pressupondo ou implicando uma mudança igualmente ao nível das políticas educativas, numa sociedade também ela cada vez mais heterogénea, pelo que a resposta está na “diversificação e gestão local do currículo”, em cujo âmbito a “(re)construção do PCT” vai assumir uma importância singular. Assim, o estudo que agora apresentamos propõe-se analisar, de maneira crítica e fundamentada, as conceções e as práticas dos docentes de uma turma do 1.º Ciclo do Ensino Básico do Funchal – RAM, no campo da reorganização curricular para este nível de ensino, estabelecida pelo Decreto-Lei n.º 6/2001, procurando entender “de que forma é que eles (re)constroem o seu PCT”, enquanto ferramenta para uma gestão curricular flexível e adequada à diversidade da turma a que se destina, à sua realidade mais particular ou específica. Nesse sentido, a recolha de dados implicou uma abordagem qualitativa, consubstanciada pela análise de documentos referentes às entrevistas, aos inquéritos por questionário, aos Projetos da escola (PEE e PCE) e ao Projeto da turma dos docentes nele envolvidos (PCT), e ainda às observações levadas a cabo na mesma. Não obstante as limitações que um estudo desta natureza apresenta, os resultados apontam para a urgência de uma mudança ao nível das práticas neste âmbito. Por conseguinte, percebemos que os docentes, de um modo geral, dominam a noção de PCT e as conceções a ele inerentes, e reconhecem as vantagens da sua (re)construção, sobretudo ao nível da oferta educativa e consequente melhoria da aprendizagem dos alunos. No entanto, também percebemos que falta melhorar certos aspetos ao nível da ação, melhor dizendo, da interação e colaboração docente, para uma mudança significativa das práticas, para uma verdadeira (re)construção do PCT. De qualquer modo, ficou patente a necessidade de uma aposta na formação dos professores, de forma a promover e estimular neles uma “cultura de Projeto”, e a dotálos com as devidas competências que lhes permitam práticas colaborativas e os ajudem na (re)construção de PCT com sentido, numa escola para todos.

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The influence of silver additions on the Cu-13 wt. pot. Al alloy hardness was studied for additions in the range 0 to 16 wt. pot Ag. The results indicated a pronounced hardness increase with the silver content and an influence of the quenching temperature. Data obtained from scanning electron microscopy indicated that the formation of silver-rich precipitates, wich change with the quenching temperature, seems to produce the changes on alloys hardness.

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The GEANT4 simulations are essential for the development of medical tomography with proton beams pCT. In the case of thin absorbers the latest releases of GEANT4 generate very similar final spectra which agree well with the results of other popular Monte Carlo codes like TRIM/SRIM, or MCNPX. For thick absorbers, however, the disagreements became evident. In a part, these disagreements are due to the known contradictions in the NIST PSTAR and SRIM reference data. Therefore, it is interesting to compare the GEANT4 results with each other, with experiment, and with diverse code results in a reduced form, which is free from this kind of doubts. In this work such comparison is done within the Reduced Calibration Curve concept elaborated for the proton beam tomography. © 2010 IEEE.

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Proton beams in medical applications deal with relatively thick targets like the human head or trunk. Thus, the fidelity of proton computed tomography (pCT) simulations as a tool for proton therapy planning depends in the general case on the accuracy of results obtained for the proton interaction with thick absorbers. GEANT4 simulations of proton energy spectra after passing thick absorbers do not agree well with existing experimental data, as showed previously. Moreover, the spectra simulated for the Bethe-Bloch domain showed an unexpected sensitivity to the choice of low-energy electromagnetic models during the code execution. These observations were done with the GEANT4 version 8.2 during our simulations for pCT. This work describes in more details the simulations of the proton passage through aluminum absorbers with varied thickness. The simulations were done by modifying only the geometry in the Hadrontherapy Example, and for all available choices of the Electromagnetic Physics Models. As the most probable reasons for these effects is some specific feature in the code, or some specific implicit parameters in the GEANT4 manual, we continued our study with version 9.2 of the code. Some improvements in comparison with our previous results were obtained. The simulations were performed considering further applications for pCT development. © 2011 American Institute of Physics.

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Abstract Background Procalcitonin (PCT) is an inflammatory marker that has been used as indicator of severe bacterial infection. We evaluated the concentrations of PCT as a marker for systemic infection compared to C-reactive protein (CRP) in patients neutropenic febrile. Methods 52 adult patients were enrolled in the study. Blood sample was collected in order to determine the serum concentrations of PCT, CRP and other hematological parameters at the onset of fever. The patients were divided into 2 groups, one with severe infection (n = 26) and the other in which the patients did not present such an infection (n = 26). Then PCT and CRP concentrations at the fever onset were compared between groups using non parametric statistical tests, ROC curve, sensitivity, specificity, likelihood ratio, and Spearman's correlation coefficient. Results The mean of PCT was significantly higher in the group with severe infection (6.7 ng/mL versus 0.6 ng/mL – p = 0.0075) comparing with CRP. Serum concentrations of 0.245 ng/mL of PCT displayed 100% de sensitivity and 69.2% specificity. PCT concentrations of 2,145 ng/mL presented a likelihood ratio of 13, which was not observed for any concentration of CRP. Conclusion PCT seems to be an useful marker for the diagnosis of systemic infection in febrile neutropenic patients, probably better than CRP.

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The effect of the applied stress on the deformation and crack nucleation and propagation mechanisms of a c-TiAl intermetallic alloy (Ti-45Al-2Nb-2Mn (at. pct)-0.8 vol. pct TiB2) was examined by means of in situ tensile (constant strain rate) and tensile-creep (constant load) experiments performed at 973 K (700 �C) using a scanning electron microscope. Colony boundary cracking developed during the secondary stage in creep tests at 300 and 400 MPa and during the tertiary stage of the creep tests performed at higher stresses. Colony boundary cracking was also observed in the constant strain rate tensile test. Interlamellar ledges were only found during the tensile-creep tests at high stresses (r>400 MPa) and during the constant strain rate tensile test. Quantitative measurements of the nature of the crack propagation path along secondary cracks and along the primary crack indicated that colony boundaries were preferential sites for crack propagation under all the conditions investigated. The frequency of interlamellar cracking increased with stress, but this fracture mechanism was always of secondary importance. Translamellar cracking was only observed along the primary crack.

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Poster session - The aim of the study was to produce an analysis of the perceived training and professional development needs of strategic level pharmacists in primary care trusts - A survey was carried out in five areas in England of the training needs of PCT strategic level pharmacists on behalf of a West Midlands Workforce Confederation - The results show an increasing recognition by PCT pharmacists of the importance of business and management training - Several key topics of direct relevance to current heath policy were not highly rated by respondents - This study identified gaps in current training provision

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This research was commissioned by the Shropshire and Staffordshire Workforce Development Confederation, to undertake a review of the education and training needs of pharmacists working at a strategic level within primary care trusts.

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There is an increasing demand for DNA analysis because of the sensitivity of the method and the ability to uniquely identify and distinguish individuals with a high degree of certainty. But this demand has led to huge backlogs in evidence lockers since the current DNA extraction protocols require long processing time. The DNA analysis procedure becomes more complicated when analyzing sexual assault casework samples where the evidence contains more than one contributor. Additional processing to separate different cell types in order to simplify the final data interpretation further contributes to the existing cumbersome protocols. The goal of the present project is to develop a rapid and efficient extraction method that permits selective digestion of mixtures. ^ Selective recovery of male DNA was achieved with as little as 15 minutes lysis time upon exposure to high pressure under alkaline conditions. Pressure cycling technology (PCT) is carried out in a barocycler that has a small footprint and is semi-automated. Typically less than 10% male DNA is recovered using the standard extraction protocol for rape kits, almost seven times more male DNA was recovered from swabs using this novel method. Various parameters including instrument setting and buffer composition were optimized to achieve selective recovery of sperm DNA. Some developmental validation studies were also done to determine the efficiency of this method in processing samples exposed to various conditions that can affect the quality of the extraction and the final DNA profile. ^ Easy to use interface, minimal manual interference and the ability to achieve high yields with simple reagents in a relatively short time make this an ideal method for potential application in analyzing sexual assault samples.^

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There is an increasing demand for DNA analysis because of the sensitivity of the method and the ability to uniquely identify and distinguish individuals with a high degree of certainty. But this demand has led to huge backlogs in evidence lockers since the current DNA extraction protocols require long processing time. The DNA analysis procedure becomes more complicated when analyzing sexual assault casework samples where the evidence contains more than one contributor. Additional processing to separate different cell types in order to simplify the final data interpretation further contributes to the existing cumbersome protocols. The goal of the present project is to develop a rapid and efficient extraction method that permits selective digestion of mixtures. Selective recovery of male DNA was achieved with as little as 15 minutes lysis time upon exposure to high pressure under alkaline conditions. Pressure cycling technology (PCT) is carried out in a barocycler that has a small footprint and is semi-automated. Typically less than 10% male DNA is recovered using the standard extraction protocol for rape kits, almost seven times more male DNA was recovered from swabs using this novel method. Various parameters including instrument setting and buffer composition were optimized to achieve selective recovery of sperm DNA. Some developmental validation studies were also done to determine the efficiency of this method in processing samples exposed to various conditions that can affect the quality of the extraction and the final DNA profile. Easy to use interface, minimal manual interference and the ability to achieve high yields with simple reagents in a relatively short time make this an ideal method for potential application in analyzing sexual assault samples.

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O presente estudo partiu de preocupações da prática relacionadas com o papel do PCT no desenvolvimento pedagógico e curricular sobretudo de alunos com dislexia. No sentido de se responder à pergunta de partida: “de que forma a diferenciação pedagógica e curricular dos alunos com DEA/Dislexia, é contemplada no PCT?” elaborou-se um quadro teórico onde se começou por discutir o papel da escola recorrendo inclusivamente à sua perspectivação histórica. Esta permitiu perceber a escola actual nomeadamente nas tensões entre os processos de massificação escolar conducentes a uma hegemonia do currículo e os processos de flexibilização curricular. O nosso interesse principal situou-se nestes últimos pela sua importância para a diferenciação curricular e pedagógica na sala de aula necessária para os alunos com dislexia. A formação dos professores desempenha neste contexto uma grande relevância, pelo que lhe atribuímos elevada importância. Utilizando como instrumentos de recolha inquéritos por questionário articulados com a análise dos PCTs inquirimos uma amostra de vinte e oito professores de um agrupamento de escolas do distrito de Santarém sobre a sua percepção face à dislexia e à importância dada à utilização do PCT. Os dados recolhidos e tratados permitiram verificar que nem os PCT são encarados como um instrumento de diferenciação curricular e pedagógica, resultando em algumas contradições entre o que se diz fazer e o que se faz efectivamente, nem a DEA/Dislexia é encarada como um problema, que apesar de real não se vê contemplada, de forma explícita nos PCT. Desta forma, consideramos que o estudo realizado (embora limitado no tempo e espaço) permite desvendar algumas das suas representações mostrando uma forte relação entre a ausência de formação e o impacto que esta lacuna tem nas práticas docentes.

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Background: Thrombocytopenia has been shown to predict mortality. We hypothesize that platelet indices may be more useful prognostic indicators. Our study subjects were children one month to 14 years old admitted to our hospital. Aim: To determine whether platelet count, plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) and their ratios can predict mortality in hospitalised children. Methods: Children who died during hospital stay were the cases. Controls were age matched children admitted contemporaneously. The first blood sample after admission was used for analysis. Receiver operating characteristic (ROC) curve was used to identify the best threshold for measured variables and the ratios studied. Multiple regression analysis was done to identify independent predictors of mortality. Results: Forty cases and forty controls were studied. Platelet count, PCT and the ratios of MPV/Platelet count, MPV/PCT, PDW/Platelet count, PDW/PCT and MPV x PDW/Platelet count x PCT were significantly different among children who survived compared to those who died. On multiple regression analysis the ratio of MPV/PCT, PDW/Platelet count and MPV/ Platelet count were risk factors for mortality with an odds ratio of 4.31(95% CI, 1.69-10.99), 3.86 (95% CI, 1.53-9.75), 3.45 (95% CI, 1.38-8.64) respectively. In 67% of the patients who died MPV/PCT ratio was above 41.8 and PDW/Platelet count was above 3.86. In 65% of patients who died MPV/Platelet count was above 3.45. Conclusion: The MPV/PCT, PDW/Platelet count and MPV/Platelet count, in the first sample after admission in this case control study were predictors of mortality and could predict 65% to 67% of deaths accurately.