RPA-1 from Leishmania amazonensis (LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Graecia Foederata sub Agamemnone, ob Helenae Raptum in Troiam coniurans / ex Homero collecta geographicis Gulielmi Sanson, Nicolai filii, Christianissimi Regis Geographi ; Lud[ovicus] Cordier sculpsit

Échelle(s) : [1:2 700 000 environ]

Reliure de : Georgii Agricolae de Re metallica libri XII, quibus officia, instrumenta, machinae ac omnia... ad metallicam spectantia non modo... describuntur, sed et per effigies... ob oculos ponuntur... Ejusdem de animantibus subterraneis liber...

Numérisation partielle de reliure

Nova mappa geographica Sueciae ac Gothiae regna ut et Finlandiae ducatum ac Lapponiam, cum provinciis minoribus, ob oculos ponens, cura et sumtibus Tobiae Conradi Lotter, chalcogr et geogr: Augustae Vindel.

Alareunassa privilegiomerkintä: Cum gratia et privil. s. r. i. vicariatq, in partibq Rheni, Sveviae, et juris Franconici.

Ob quas Hieromonachus Stephanus Presbytovitsch ingentem in Russia passus est persecutionem, ad verbi divini canonem examinatas

Nimekettä edeltää hepreankielinen invokaatio.

Ob quas Hieromonachus Stephanus Presbytovitsch ingentem in Russia passus est persecutionem, ad verbi divini canonem examinatas

Nimekettä edeltää hepreankielinen invokaatio.

1.° Comoedia Marabei, Mendici : authoris nomen non comparet. — 2.° Comoedia Licocorduli ; sive, relictor cuculli, comoedia : authore anonymo. — 3.° Anonymi opusculum cujus titulus : Dialogus longè facetissimus de temporum ac scientiarum mutatione, disputationem praesertim Sophistici et Logodaedali complectens : est autem de abjiciendis praecipuè Sophistarum gerris ; similiter et de matrimonio Praeceptoribus minùs convenienti, ob uxoris gravitatem et pondus. — 4.° Institutiones rhetoricae in tabulas distributae : authore Philippo Boisotio Rollando.

Colbertinus

Motus proprius S.D.N. Pii Papae V : in quo confirmantur constitutiones diuersoru. Rom. Pont super annatis communibus & alijs iuribus ob vniones beneficiorum soluendis...

Inicial grab. xil

Gadicensium luctus ob hispaniarum reginae infantisque serenissimae discessum [Texto impreso] ...]

Probablemente impreso en 1868, año en que Isabel II es derrocada y parte hacia el exilio

Constitutive and impaired signaling of leptin receptors containing the Gln → Pro extracellular domain fatty mutation

Leptin (OB), an adipocyte-secreted circulating hormone, and its receptor (OB-R) are key components of an endocrine loop that regulates mammalian body weight. In this report we have analyzed signal transduction activities of OB-R containing the fatty mutation [OB-R(fa)], a single amino acid substitution at position 269 (Gln → Pro) in the OB-R extracellular domain that results in the obese phenotype of the fatty rat. We find that this mutant receptor exhibits both ligand-independent transcriptional activation via interleukin 6 and hematopoietin receptor response elements and ligand-independent activation of signal transducer and activator of transcription (STAT) proteins 1 and 3. However, OB-R(fa) is unable to constitutively activate STAT5B and is highly impaired for ligand induced activation of STAT5B compared with OB-R(wt). Introduction of the fatty mutation into a OB-R/G-CSF-R chimera generates a receptor with constitutive character that is similar but distinct from that of OB-R(fa). Constitutive mutant OB-R(fa) receptor signaling is repressed by coexpression of OB-R(wt). The implications of an extracellular domain amino acid substitution generating a cytokine receptor with a partially constitutive phenotype are discussed both in terms of the mechanism of OB-R triggering and the biology of the fatty rat.

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Leptin is an adipocyte-derived cytokine that regulates food intake and body weight via interaction with its Ob receptor (ObR). Serum leptin levels are chronically elevated in obese humans, suggesting that obesity may be associated with leptin resistance and the inability to generate an adequate ObR response. Evidence suggests that transcriptional activation of target genes by STAT3 (signal transducer and activator of transcription) in the hypothalamus is a critical pathway that mediates leptin’s action. Herein we report that activation of ObR induces the tyrosine phosphorylation of the tyrosine phosphatase SH2-containing phosphatase 2 (SHP-2) and demonstrate that Tyr986 within the ObR cytoplasmic domain is essential to mediate phosphorylation of SHP-2 and binding of SHP-2 to ObR. Surprisingly, mutation of Tyr986 to Phe, which abrogates SHP-2 phosphorylation and binding to the receptor, dramatically increases gene induction mediated by STAT3. Our findings indicate that SHP-2 is a negative regulator of STAT3-mediated gene induction after activation of ObR and raise the possibility that blocking the interaction of SHP-2 with ObR could overcome leptin resistance by boosting leptin’s weight-reducing effects in obese individuals.

Ueber colonieen. Ob und wie solche in cultivirten staaten noch einführbar und nützlich seyn möchten.

Mode of access: Internet.

Zwey Abhandlungen über Frachtwägen und Strassen und über die Frage, ob, und in welchen Fällen der Bau schiffbarer Kanäle, Eisenwege, oder gemachter Strassen vorzuziehen sey : nach einer Untersuchung, ob die Moldau mit der Donau durch einen Schiffahrtkanal zu vereinigen sey /

Errata: 2 p. (at end).

Die Religionsphilosophie des Als-ob : eine Nachprüfung Kants und des idealistischen Positivismus /

Mode of access: Internet.