From the Hill

Q&A: Desiree Shayer '12, studying in Amman, Jordan, talks about presenting her research, Jan Plan in Israel, and witnessing one part of the Middle East revolution A Natural Writer: With carefully chosen words, Blair Braverman '11 sets out to raise environmental awareness Sixty Years, One Musical Language: Colbyettes from across generations compare notes, sing again The Whole Truth: Foreign correspondent Gerry Hadden tells the stories behind his radio reports from Latin America and Haiti Writing the Final Chapter Kennebec Highlands Vista Handwriting on the Wall To Timbuktu--and Back: Steven Weinberg and Casey Scieszka turn exploration into a charming and informative collaboration Turning Experience Into Success Ultimate Goes National Family Matters: Women's lacrosse coach Karen MacCrate Henning ties success to team unity, unselfishness One Fast Mule Sports Shorts

Biological monitoring of exposure to solvents using the chemical itself in urine: application to toluene

Objective Biomonitoring of solvents using the unchanged substance in urine as exposure indicator is still relatively scarce due to some discrepancies between the results reported in the literature. Based on the assessment of toluene exposure, the aim of this work was to evaluate the effects of some steps likely to bias the results and to measure urinary toluene both in volunteers experimentally exposed and in workers of rotogravure factories. Methods Static headspace was used for toluene analysis. o-Cresol was also measured for comparison. Urine collection, storage and conservation conditions were studied to evaluate possible loss or contamination of toluene in controlled situations applied to six volunteers in an exposure chamber according to four scenarios with exposure at stable levels from 10 to 50 ppm. Kinetics of elimination of toluene were determined over 24 h. A field study was then carried out in a total of 29 workers from two rotogravure printing facilities. Results Potential contamination during urine collection in the field is confirmed to be a real problem but technical precautions for sampling, storage and analysis can be easily followed to control the situation. In the volunteers at rest, urinary toluene showed a rapid increase after 2 h with a steady level after about 3 h. At 47.1 ppm the mean cumulated excretion was about 0.005% of the amount of the toluene ventilated. Correlation between the toluene levels in air and in end of exposure urinary sample was excellent (r = 0.965). In the field study, the median personal exposure to toluene was 32 ppm (range 3.6-148). According to the correlations between environmental and biological monitoring data, the post-shift urinary toluene (r = 0.921) and o-cresol (r = 0.873) concentrations were, respectively, 75.6 mu g/l and 0.76 mg/g creatinine for 50 ppm toluene personal exposure. The corresponding urinary toluene concentration before the next shift was 11 mu g/l (r = 0.883). Conclusion Urinary toluene was shown once more time a very interesting surrogate to o-cresol and could be recommended as a biomarker of choice for solvent exposure. [Authors]

The hope for an HIV vaccine based on induction of CD8+ T lymphocytes: a review

The only long-term and cost-effective solution to the human immunodeficiency virus (HIV) epidemic in the developing world is a vaccine that prevents individuals from becoming infected or, once infected, from passing the virus on to others. There is currently little hope for an AIDS vaccine. Conventional attempts to induce protective antibody and CD8+ lymphocyte responses against HIV and simian immunodeficiency virus (SIV) have failed. The enormous diversity of the virus has only recently been appreciated by vaccinologists, and our assays to determine CD8+ lymphocyte antiviral efficacy are inadequate. The central hypothesis of a CTL-based vaccine is that particularly effective CD8+ lymphocytes directed against at least five epitopes that are derived from regions under functional and structural constraints will control replication of pathogenic SIV. This would be somewhat analogous to control of virus replication by triple drug therapy or neutralizing antibodies.

Never the twain shall meet: A memetic analysis of poverty perceptions

Poverty, as defined within development discourse, does not fully capture the reality in which the poor live, which is formed also by values and beliefs specific to a given culture and setting. This article uses a memetic approach to investigating the reality of poverty among pastoralists and urban dwellers in Kenya. By distinguishing the semantic space and the cultural context in which the definitions are framed, it enables the researcher to make sufficient generalisations while also recognising the differences between cultures. The results demonstrate how pastoralists and urban dwellers conceptualise poverty differently particularly in regard to causes. Further, the article suggests that development actors often utilise a Western construct which does not entirely reflect the values and beliefs of the poor.

The cell cycle and drug discovery: The promise and the hope

In recent years, there have been major developments in the understanding of the cell cycle. It is now known that normal cellular proliferation is tightly regulated by the activation and deactivation of a series of proteins that constitute the cell cycle machinery. The expression and activity of components of the cell cycle can be altered during the development of a variety of diseases where aberrant proliferation contributes to the pathology of the illness. Apart from yielding a new source of untapped therapeutic targets, it is likely that manipulating the activity of such proteins in diseased states will provide an important route for treating proliferative disorders, and the opportunity to develop a novel class of future medicines.

Leaving the Court, But Never the Team: Legendary coach Dick Whitmore retires after 40 years, but his relationship with his "basketball people" endures

Legendary coach Dick Whitmore retires after 40 years, but his relationship with his “basketball people” endures.

You are the hope of the world! : an appeal to the girls and boys of America /

Mode of access: Internet.

A course of lectures on the figurative language of the Holy Scripture : and the interpretation of it from the Scripture itself /

Mode of access: Internet.

Outlines of English grammar as evolved from the language itself /

Mode of access: Internet.

Catalogue of the celebrated collection of Greek, Roman & Egyptian sculpture and ancient Greek vases : being a portion of the Hope heirlooms removed from Deepdene, Dorking, the property of Lord Francis Pelham Clinton Hope, which will be sold by auction by Christie, Manson & Woods... London, on Monday, July 23, 1917...

Mode of access: Internet.

The hope of the future : the management of children in health and disease /

Includes index.

Forest ecology ; the forest environment, the forest community and the forest itself.

Includes bibliography.

Nature of the country itself.

Caption title.