927 resultados para Neutral axis shift


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Este relatório é elaborado no âmbito do estágio curricular no regime de parceria entre o Instituto Superior de Engenharia do Porto e o gabinete de projetos SE2P – Sociedade de Engenharia, Projetos e Planeamento, Lda. O tema do estágio é o estudo de colunas mistas aço-betão na vertente de projeto, mais concretamente através da criação dum processo de cálculo automático integrado com o modelo estrutural global. Aplicam-se os métodos de dimensionamento dos eurocódigos estruturais na avaliação da segurança dos estados limites. Avaliam-se as propriedades geométricas, determina-se a curva de interação, calcula-se a posição do eixo neutro donde se inferem os estados de tensão em flexão desviada ao nível da secção, necessários às verificações de segurança. O processo de cálculo tem por base uma folha de cálculo desenvolvida em Excel que, com ajuda do Visual Basic for Applications, comunica com o software de modelação e cálculo estrutural Autodesk Robot Professional Analisys. Cria-se fluxos de informação que possibilitam o cálculo iterativo de colunas mistas permitindo ajustar e por esta via otimizar as soluções de dimensionamento. A exportação de relatórios de cálculo detalhados para cada coluna constitui uma mais-valia para gabinetes de engenharia quando comparada com outras soluções de dimensionamento existentes no mercado. A aplicação do processo de cálculo desenvolvido a múltiplas combinações de soluções de colunas mistas permitiu analisar comparativamente os resultados obtidos e a criação de tabelas e ábacos que poderão ser úteis em cenários de pré-dimensionamento e de anteprojeto.

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The aim of this retrospective study was to compare the clinical and radiographic results after TKA (PFC, DePuy), performed either by computer assisted navigation (CAS, Brainlab, Johnson&Johnson) or by conventional means. Material and methods: Between May and December 2006 we reviewed 36 conventional TKA performed between 2002 and 2003 (group A) and 37 navigated TKA performed between 2005 and 2006 (group B) by the same experienced surgeon. The mean age in group A was 74 years (range 62-90) and 73 (range 58-85) in group B with a similar age distribution. The preoperative mechanical axes in group A ranged from -13° varus to +13° valgus (mean absolute deviation 6.83°, SD 3.86), in group B from -13° to +16° (mean absolute deviation 5.35, SD 4.29). Patients with a previous tibial osteotomy or revision arthroplasty were excluded from the study. Examination was done by an experienced orthopedic resident independent of the surgeon. All patients had pre- and postoperative long standing radiographs. The IKSS and the WOMAC were utilized to determine the clinical outcome. Patient's degree of satisfaction was assessed on a visual analogous scale (VAS). Results: 32 of the 37 navigated TKAs (86,5%) showed a postoperative mechanical axis within the limits of 3 degrees of valgus or varus deviation compared to only 24 (66%) of the 36 standard TKAs. This difference was significant (p = 0.045). The mean absolute deviation from neutral axis was 3.00° (range -5° to +9°, SD: 1.75) in group A in comparison to 1.54° (range -5° to +4°, SD: 1.41) in group B with a highly significant difference (p = 0.000). Furthermore, both groups showed a significant postoperative improvement of their mean IKSS-values (group A: 89 preoperative to 169 postoperative, group B 88 to 176) without a significant difference between the two groups. Neither the WOMAC nor the patient's degree of satisfaction - as assessed by VAS - showed significant differences. Operation time was significantly higher in group B (mean 119.9 min.) than in group A (mean 99.6 min., p <0.000). Conclusion: Our study showed consistent significant improvement of postoperative frontal alignment in TKA by computer assisted navigation (CAS) compared to standard methods, even in the hands of a surgeon well experienced in standard TKA implantation. However, the follow-up time of this study was not long enough to judge differences in clinical outcome. Thus, the relevance of computer navigation for clinical outcome and survival of TKA remains to be proved in long term studies to justify the longer operation time. References 1 Stulberg SD. Clin Orth Rel Res. 2003;(416):177-84. 2 Chauhan SK. JBJS Br. 2004;86(3):372-7. 3 Bäthis H, et al. Orthopäde. 2006;35(10):1056-65.

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Pós-graduação em Engenharia Mecânica - FEIS

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El principal objetivo de este estudio es evaluar la influencia de las fendas de secado en las propiedades mecánicas de vigas de madera. Para esto, se utilizan 40 vigas de Pino silvestre (Pinus sylvestris L) de 4200 mm de longitud y 150x200 mm de sección que fueron ensayadas según norma EN 408. Las fendas se registran detalladamente atendiendo a su longitud y posición en cada cara de la viga, y midiendo el espesor y la profundidad cada 100mm a lo largo de la viga. Solo el 10% de la muestra es rechazada por las fendas, según los criterios establecidos por la norma española de clasificación visual UNE 56544. Para evaluar la influencia de las fendas en las propiedades mecánicas, se usan tres parámetros globales basados en el área, el volumen o la profundad de la fenda, y dos locales basados en la profundidad máxima y la profundidad en la zona de rotura. Además se determina la densidad de las piezas. Estos parámetros se comparan con las propiedades mecánicas (tensión de rotura, módulo de elasticidad y energía de rotura) y se encuentra escasa relación entre ellos. Las mejores correlaciones se encuentran entre los parámetros relacionados con la profundidad de las fendas, tanto con el módulo de elasticidad como con la tensión de rotura. The aim of this study is the evaluation of the influence of drying fissures on the mechanical properties of timber beams. For that purpose, 40 sawn timber pieces of Scots pine (Pinus sylvestris L.) with 150x200 mm in cross-section and 4200 mm in length have been tested according to EN 408, obtaining MOR and MOE. The fissures were registered in detail measuring their length and position in each face of the beam, and the thickness and depth every 100 mm in length. Only 10 % of the pieces were rejected because fissures, according to UNE 56544 Spanish visual grading standard. To evaluate the influence of fissures in mechanical properties three global parameters: Fissures Area Ratio or ratio between the area occupied by fissures and the total area in the neutral axis plane of the beam; Fissures Volume Ratio or ratio between volume of fissures and the total volume of the beam; Fissures Average Depth and two local parameters were used: Fissures Maximum Depth in the beam, and Fissures Depth in the broken zone of the beam. Also the density of the beams was registered. These parameters were compared with mechanical properties (tensile strength, elasticity modulus, and rupture energy) and the relationship between them had not been founded. The best relationship was founded between the elasticity modulus y the tensile strength with the parameters which included the depth of the fissures.

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Aunque las primeras fábricas de tubos de poliéster reforzado con fibra de vidrio en España datan del año 1984, no es sino hasta el año 1996 cuando se comienza su utilización masiva como un sustituto de las tuberías de fribrocemento, que ya habían sido prohibidas por la legislación, debido a los efectos cancerígenos de este material. Desde entonces se ha prodigado la utilización de todas las diferentes tipologías de esta clase de tubería, de conformidad a los procesos de fabricación empleados que se encuentran recopilados en el AWWA Manual M45 (Fiberglass Pipe Design), obteniéndose muy diversos resultados. Durante estos años, ha surgido una creciente preocupación en los usuarios de este tipo de tuberías dadas las continuas y numerosas averías en todo el ámbito geográfico. Esto ha promovido el desarrollo de la presente investigaicón, que se ha dividido en dos partes y que ha concluido con la determinación de un nuevo mecanismo específico de fractura. La primera parte se centró en la obtención y desarrollo del modelo teórico que hemos venido a denominar como "Teoría de la Caja Mecánicamente Contaminada", y que está basado en la contaminación o separación por un impacto de dos de las tres capas que forman la tubería, la capa intermedia de arena y la capa más interna o "inner layer". La consecuencia es la disminución del canto resistente, la rotura del inner layer y la entrada de fluido a la capa de arena. Para la evaluación de la magnitud de esta separación se ha desarrollado un modelo analítico que ha determinado la existencia de una relación cuadrática que la rige, y que ha sido verificado mediante ensayos de impacto sobre probetas de tuberías, alcanzando ajustes de hasta el 92%. Así, se ha determinado que impactos de muy baja intensidad, del entorno de 90 a 160 Julios en tuberías Filament Winding continuo PN 16-20 (de 800 a 1000mm) pueden comprometer seriamente la integridad estructural de la tubería sin dejar, en un principio, muesca o traza alguna que pueda alertar del problema. Los siguientes pasos en el estudio se dirigieron a determinar qué otros mecanismos, aparte del golpe, podrían contaminar la tubería y a estudiar el consiguiente avance de la fractura a las capas externas. Se trataba además de analizar la aparición en el tubo de unas misteriosas manchas en forma de "piel de leopardo" y de otros fenómenos aparecidos en las averías como que algunas de las deformaciones de la rotura por presión interna son hacia el interior del tubo y no al revés, como habría sido de esperar a priori. Se optó entonces por comenzar la que ha constituido la segunda parte de la investigación. Para ello se recurrió a realizar ensayos hidráulicos en banco de pruebas a alta presión, cuyos resultados fueron sorprendentes al descubrir que en el proceso se producía la hidrólisis de la resina de poliéster no catalizada que fluía hacia el exterior del tubo. Como consecuencia se llevaron a cabo nuevos ensayos físicos y químicos para estudiar la migración del material y la hidrólisis producida en el proceso de fractura. En este estudio, resultó muy relevante el hecho de sobrepasar o no la presión que producía el desagarro entre las capas del tubo. En definitiva, en esta investigación, que ha constado de estudios analíticos y estudios experimentales, químicos y numéricos, se ha determinado un nuevo mecanismo de fractura que explica gran parte de los fallos acontecidos en las tuberías de poliéster reforzado con fibra de vidrio. Como aplicación se exponen recomendaciones para mejorar el comportamiento mecánico de esta tipología y evitar así los sobrecostes millonarios producidos por su reposición. Numerous and continuous failures in fiberglass reinforced polyester pipes of different companies and manufacturing processes of the AWWA Manual M45 (Fiberglass Pipe Design), have prompted the development of this research, that has concluded with a specific mechanism describing pipe fractures. This research was carried out via two independent studies. The first one is the development of the hypothesis that turned into the Mechanically Contaminated Layer Theory. This theory describes the fracture mchanism which explains a significant part of massive failures due to the existence of a sand layer placed near the neutral axis in the core making the composite very sensitive to impacts in fibreglass reinforced polyester pipes. These failures create interface delamination and consequently fluid can leak into supporting sand backfill thereby iniating the fracture process. In order to assess the delimination magnitude, an analytic method is developed and a squared root law between delamination and energy applied proposed. Vertical blunt ram testts on samples extracted from complete pipes have been carried out to verify this theory, reaching a goodness of fit up to 92%. It is concluded that low energy impacts, around 90-160J in 800-1000mm diameter PN 16-20 continuous filament winding pipes, can seriously compromise their structural integraty with no external trace. The next step in the study was to determine what other mechanism, apart from the brittle hit, could contaminate the pipe and to analyse the consequente advance of the fracture to the external layers. Another aim was to analyse two phenomena occurred in real pipe failures. The first one is the appearance on the tube of "leopard fur" stains on some of the analysed failures, and the other phenomenon is the "inverse fracture", in which the deformations of the failure due to internal pressure are towards the inside of the tube and not the other way round, as it would be expected. It was then chosen to follow a new branch of the investigation by hydraulic high-pressure bench tests that study seepage and load transmission. The results were very surprising as it was discovered that in the process, hydrolysis of the non-catalysed polyester resin occured, flowing towards the outer of the pipe, which entailed the development of chemical and physical tests of the exuded material to study material migration and hydrolysis of the fracture process. In this particular study it was relevant to exceed or not the pressure that produced the rip between the layers of the tube. In conclusion, a new breakage mechanism in FRP pies with sand-filled layer has been found, which explains a high part of the failure global cases. The whole failure process is justified by the Mechanically Contaminated Layer Theory, which has been corroborated by means of analytical, numerical and experimental studies. Several recommendations are also provided in order to improve the mechanical behaviour of this typology and avoid the millionaire overruns generated by its massive failures.

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Arch bridge structural solution has been known for centuries, in fact the simple nature of arch that require low tension and shear strength was an advantage as the simple materials like stone and brick were the only option back in ancient centuries. By the pass of time especially after industrial revolution, the new materials were adopted in construction of arch bridges to reach longer spans. Nowadays one long span arch bridge is made of steel, concrete or combination of these two as "CFST", as the result of using these high strength materials, very long spans can be achieved. The current record for longest arch belongs to Chaotianmen bridge over Yangtze river in China with 552 meters span made of steel and the longest reinforced concrete type is Wanxian bridge which also cross the Yangtze river through a 420 meters span. Today the designer is no longer limited by span length as long as arch bridge is the most applicable solution among other approaches, i.e. cable stayed and suspended bridges are more reasonable if very long span is desired. Like any super structure, the economical and architectural aspects in construction of a bridge is extremely important, in other words, as a narrower bridge has better appearance, it also require smaller volume of material which make the design more economical. Design of such bridge, beside the high strength materials, requires precise structural analysis approaches capable of integrating the combination of material behaviour and complex geometry of structure and various types of loads which may be applied to bridge during its service life. Depend on the design strategy, analysis may only evaluates the linear elastic behaviour of structure or consider the nonlinear properties as well. Although most of structures in the past were designed to act in their elastic range, the rapid increase in computational capacity allow us to consider different sources of nonlinearities in order to achieve a more realistic evaluations where the dynamic behaviour of bridge is important especially in seismic zones where large movements may occur or structure experience P - _ effect during the earthquake. The above mentioned type of analysis is computationally expensive and very time consuming. In recent years, several methods were proposed in order to resolve this problem. Discussion of recent developments on these methods and their application on long span concrete arch bridges is the main goal of this research. Accordingly available long span concrete arch bridges have been studied to gather the critical information about their geometrical aspects and properties of their materials. Based on concluded information, several concrete arch bridges were designed for further studies. The main span of these bridges range from 100 to 400 meters. The Structural analysis methods implemented in in this study are as following: Elastic Analysis: Direct Response History Analysis (DRHA): This method solves the direct equation of motion over time history of applied acceleration or imposed load in linear elastic range. Modal Response History Analysis (MRHA): Similar to DRHA, this method is also based on time history, but the equation of motion is simplified to single degree of freedom system and calculates the response of each mode independently. Performing this analysis require less time than DRHA. Modal Response Spectrum Analysis (MRSA): As it is obvious from its name, this method calculates the peak response of structure for each mode and combine them using modal combination rules based on the introduced spectra of ground motion. This method is expected to be fastest among Elastic analysis. Inelastic Analysis: Nonlinear Response History Analysis (NL-RHA): The most accurate strategy to address significant nonlinearities in structural dynamics is undoubtedly the nonlinear response history analysis which is similar to DRHA but extended to inelastic range by updating the stiffness matrix for every iteration. This onerous task, clearly increase the computational cost especially for unsymmetrical buildings that requires to be analyzed in a full 3D model for taking the torsional effects in to consideration. Modal Pushover Analysis (MPA): The Modal Pushover Analysis is basically the MRHA but extended to inelastic stage. After all, the MRHA cannot solve the system of dynamics because the resisting force fs(u; u_ ) is unknown for inelastic stage. The solution of MPA for this obstacle is using the previously recorded fs to evaluate system of dynamics. Extended Modal Pushover Analysis (EMPA): Expanded Modal pushover is a one of very recent proposed methods which evaluates response of structure under multi-directional excitation using the modal pushover analysis strategy. In one specific mode,the original pushover neglect the contribution of the directions different than characteristic one, this is reasonable in regular symmetric building but a structure with complex shape like long span arch bridges may go through strong modal coupling. This method intend to consider modal coupling while it take same time of computation as MPA. Coupled Nonlinear Static Pushover Analysis (CNSP): The EMPA includes the contribution of non-characteristic direction to the formal MPA procedure. However the static pushovers in EMPA are performed individually for every mode, accordingly the resulted values from different modes can be combined but this is only valid in elastic phase; as soon as any element in structure starts yielding the neutral axis of that section is no longer fixed for both response during the earthquake, meaning the longitudinal deflection unavoidably affect the transverse one or vice versa. To overcome this drawback, the CNSP suggests executing pushover analysis for governing modes of each direction at the same time. This strategy is estimated to be more accurate than MPA and EMPA, moreover the calculation time is reduced because only one pushover analysis is required. Regardless of the strategy, the accuracy of structural analysis is highly dependent on modelling and numerical integration approaches used in evaluation of each method. Therefore the widely used Finite Element Method is implemented in process of all analysis performed in this research. In order to address the study, chapter 2, starts with gathered information about constructed long span arch bridges, this chapter continuous with geometrical and material definition of new models. Chapter 3 provides the detailed information about structural analysis strategies; furthermore the step by step description of procedure of all methods is available in Appendix A. The document ends with the description of results and conclusion of chapter 4.

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BACKGROUND: Endothelial Progenitor Cells (EPC) support neovascularization and regeneration of injured endothelium both by providing a proliferative cell pool capable of differentiation into mature vascular endothelial cells and by secretion of angiogenic growth factors. OBJECTIVE: The aim of this study was to investigate the role of PDGF-BB and PDGFR in EPC-mediated angiogenesis of differentiated endothelial cells. METHODS AND RESULTS: Conditioned medium from human EPC (EPC-CM) cultured in hypoxic conditions contained substantially higher levels of PDGF-BB as compared to normoxic conditions (P<0.01). EPC-CM increased proliferation (1.39-fold; P<0.001) and migration (2.13-fold; P<0.001) of isolated human umbilical vein endothelial cells (HUVEC), as well as sprouting of vascular structures from ex vivo cultured aortic rings (2.78-fold increase; P = 0.01). The capacity of EPC-CM to modulate the PDGFR expression in HUVEC was assessed by western blot and RT-PCR. All the pro-angiogenic effects of EPC-CM on HUVEC could be partially inhibited by inactivation of PDGFR (P<0.01). EPC-CM triggered a distinct up-regulation of PDGFR (2.5±0.5; P<0.05) and its phosphorylation (3.6±0.6; P<0.05) in HUVEC. This was not observed after exposure of HUVEC to recombinant human PDGF-BB alone. CONCLUSION: These data indicate that EPC-CM sensitize endothelial cells and induce a pro-angiogenic phenotype including the up-regulation of PDGFR , thereby turning the PDGF/PDGFR signaling-axis into a critical element of EPC-induced endothelial angiogenesis. This finding may be utilized to enhance EPC-based therapy of ischemic tissue in future.

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We study the existence of global solutions for a class of abstract neutral differential equation defined on the whole real axis. Some concrete applications related to ordinary and partial differential equations are considered. (C) 2009 Elsevier Ltd. All rights reserved.

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We study the existence of mild solutions for a class of impulsive neutral functional differential equation defined on the whole real axis. Some concrete applications to ordinary and partial neutral differential equations with impulses are considered. (C) 2010 Elsevier Ltd. All rights reserved.

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Objective. To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Patients and Methods. 70 patients with early-stage PC were treated with RP and their tumor samples were evaluated for expression of NEP, endothelin-1 (ET-1) and NFκB (p65). Time to PSA recurrence was correlated with the examined parameters and combined with preoperative PSA level, Gleason score, pathological TNM (pT) stage, and surgical margin (SM) assessment. Results and Limitations. Membranous expression of NEP (P < 0.001), cytoplasmic ET-1 (P = 0.002), and cytoplasmic NFκB (P < 0.001) were correlated with time to PSA relapse. NEP was associated with ET-1 (P < 0.001) and NFκB (P < 0.001). ET-1 was also correlated with NFκB (P < 0.001). NEP expression (P = 0.017), pT stage (P = 0.013), and SMs (P = 0.036) were independent predictors of time to PSA recurrence. Conclusions. There seems to be a clinical model of NEP/NPs and NFκB pathways interconnection, with their constituents following inverse patterns of expression in accordance with their biological roles and molecular interrelations.

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We consider noncentered vortices and their arrays in a cylindrically trapped Bose-Einstein condensate at zero temperature. We study the kinetic energy and the angular momentum per particle in the Thomas-Fermi regime and their dependence on the distance of the vortices from the center of the trap. Using a perturbative approach with respect to the velocity field of the vortices, we calculate, to first order, the frequency shift of the collective low-lying excitations due to the presence of an off-center vortex or a vortex array, and compare these results with predictions that would be obtained by the application of a simple sum-rule approach, previously found to be very successful for centered vortices. It turns out that the simple sum-rule approach fails for off-centered vortices.

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The electronic structure of an isolated oxygen vacancy in SrTiO3 has been investigated with a variety of ab initio quantum mechanical approaches. In particular we compared pure density functional theory (DFT) approaches with the Hartree-Fock method, and with hybrid methods where the exchange term is treated in a mixed way. Both local cluster models and periodic calculations with large supercells containing up to 80 atoms have been performed. Both diamagnetic (singlet state) and paramagnetic (triplet state) solutions have been considered. We found that the formation of an O vacancy is accompanied by the transfer of two electrons to the 3d(z2) orbitals of the two Ti atoms along the Ti-Vac-Ti axis. The two electrons are spin coupled and the ground state is diamagnetic. New states associated with the defect center appear in the gap just below the conduction band edge. The formation energy computed with respect to an isolated oxygen atom in the triplet state is 9.4 eV.

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The electronic structure of an isolated oxygen vacancy in SrTiO3 has been investigated with a variety of ab initio quantum mechanical approaches. In particular we compared pure density functional theory (DFT) approaches with the Hartree-Fock method, and with hybrid methods where the exchange term is treated in a mixed way. Both local cluster models and periodic calculations with large supercells containing up to 80 atoms have been performed. Both diamagnetic (singlet state) and paramagnetic (triplet state) solutions have been considered. We found that the formation of an O vacancy is accompanied by the transfer of two electrons to the 3d(z2) orbitals of the two Ti atoms along the Ti-Vac-Ti axis. The two electrons are spin coupled and the ground state is diamagnetic. New states associated with the defect center appear in the gap just below the conduction band edge. The formation energy computed with respect to an isolated oxygen atom in the triplet state is 9.4 eV.

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We report on a first search for resonant pair production of neutral long-lived particles (NLLP) which each decay to a bb̄ pair, using 3.6fb-1 of data recorded with the D0 detector at the Fermilab Tevatron collider. We search for pairs of displaced vertices in the tracking detector at radii in the range 1.6-20cm from the beam axis. No significant excess is observed above background, and upper limits are set on the production rate in a hidden-valley benchmark model for a range of Higgs boson masses and NLLP masses and lifetimes. © 2009 The American Physical Society.

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We study the spatial and temporal distribution of hydrogen energetic neutral atoms (ENAs) from the heliosheath observed with the IBEX-Lo sensor of the Interstellar Boundary EXplorer (IBEX) from solar wind energies down to the lowest available energy (15 eV). All available IBEX-Lo data from 2009 January until 2013 June were included. The sky regions imaged when the spacecraft was outside of Earth's magnetosphere and when the Earth was moving toward the direction of observation offer a sufficient signal-to-noise ratio even at very low energies. We find that the ENA ribbon—a 20° wide region of high ENA intensities—is most prominent at solar wind energies whereas it fades at lower energies. The maximum emission in the ribbon is located near the poles for 2 keV and closer to the ecliptic plane for energies below 1 keV. This shift is an evidence that the ENA ribbon originates from the solar wind. Below 0.1 keV, the ribbon can no longer be identified against the globally distributed ENA signal. The ENA measurements in the downwind direction are affected by magnetospheric contamination below 0.5 keV, but a region of very low ENA intensities can be identified from 0.1 keV to 2 keV. The energy spectra of heliospheric ENAs follow a uniform power law down to 0.1 keV. Below this energy, they seem to become flatter, which is consistent with predictions. Due to the subtraction of local background, the ENA intensities measured with IBEX agree with the upper limit derived from Lyα observations.