Manifestacion de las razones, y fundamentos, que tuvo el Dr. Andres Piquer, medico titular desta ilustre ciudad de Valenica, y Cathedratico de Anatomia en su Universidad, para juzgar, y declarar ser hetico Vicente Navarro Escribano .. [Texto impreso]

Pie de imprenta tomado de colofón

Manifestacion de las razones, y fundamentos, que tuvo el Dr. Andres Piquer, medico titular desta ilustre ciudad de Valencia, y Cathedratico de Anatomia en su Universidad, para juzgar, y declarar ser hetico Vicente Navarro Escrivano ...

Mode of access: Internet.

Tino Navarro (MGN Filmes): "A quota nacional do cinema português é um décimo da média europeia. Porquê?"

O projecto “Principais tendências no cinema português contemporâneo” nasceu no Departamento de Cinema da ESTC, com o objectivo de desenvolver investigação especializada a partir de um núcleo formado por alunos da Licenciatura em Cinema e do Mestrado em Desenvolvimento de Projecto Cinematográfico, a que se juntaram professores-investigadores membros do CIAC e convidados. O que agora se divulga corresponde a dois anos e meio de trabalho desenvolvido pela equipa de investigação, entre Abril de 2009 e Novembro de 2011. Dada a forma que ele foi adquirindo, preferimos renomeá-lo, para efeitos de divulgação, “Novas & velhas tendências no cinema português contemporâneo”.

Occurrence and bioaccumulation study of PCDD and PCDF from mineral feed additives

Occurrence of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) was evaluated in sepiolite as a widely employed binder and anti-caking agent for animal feed. Also, naturally contaminated kaolinitic clay was used for comparative purposes. Since sepiolite shows remarkable adsorption properties, particular interest was paid to the extraction steps as they become critical for the final determination of these pollutants in such matrixes. Furthermore, classical Soxhlet extraction using different extracting strategies as well as acid treatment were carried out with simultaneous liquid-liquid extraction. Results obtained depended on the extraction procedure applied. Acid treatment or Soxhlet extraction using a mixture of toluene:ethanol as solvent allowed to reach the minimum requirements of recovery rates. However, Soxhlet extraction using a mixture cyclohexane:toluene as extracting solvent did not allow to comply with minimum specifications for recovery. Significant differences were obtained in TEQ units when acid treatment was applied in comparison to Soxhlet extraction. This fact can be explained because the use of drastic acid conditions allows removing strongly adsorbed analytes which can be uniquely extracted after a total destruction of the crystalline structure of sepiolite. On the contrary, Soxhlet extraction was not able to destroy the structure of sepiolite and as a consequence the PCDDs/Fs were strongly adsorbed in the internal structure of the mineral. From biological point of view the availability of these toxicants constitutes a critical aspect playing an important role in the final decision choosing particular analytical procedures. Then, acid conditions in the digestive tract should be taken into account. In this scenario, a bioaccumulation study was conducted to evaluate the transference of PCDDs/PCDFs from the sepiolite into the animal tissues when fed with feed containing sepiolite. To this end, chickens were used as a model to examine the bioavailability of PCDDs/PCDFs. Four groups of chickens were exposed through their diet to a control feed, feed with 3% w/w sepiolite as additive, feed contaminated with PCDDs/PCDFs at concentration around 2.8 pg WHO-TEQ/g and feed with 2% of a contaminated kaolinitic clay (460 pg TEQ/g mineral). Livers of the four studied groups were analyzed throughout the exposure period. Results of this trial showed that the performance of broilers was not affected by the presence of dioxins at levels tested, and chickens did not show any abnormal behaviour. Dioxins intentionally added to the diet were absorbed and accumulated in the liver in a significant manner, whereas the PCDDs/Fs from sepiolite were not available for chickens since livers from broilers fed 3% sepiolite presented similar WHO-TEQ values than those from broilers fed control diet.

Sobre los subsistemas input-output en el análisis de emisiones contaminantes. Una aplicación a las emisiones de CH4 en Cataluña

En el presente trabajo se desarrolla un estudio de las emisiones de CH4 relacionadas con el sector agroalimentario catalán a través de un análisis alternativo, o al menos complementario, de subsistemas input-output. Una herramienta de gran utilidad para estudiar la estructura productiva de los diferentes sectores que componen una economía. La aplicación de esta técnica permite las descomposición del subsistema en distintos efectos en función de los vínculos intersectoriales existentes con el conjunto de las ramas productivas de la economía, dentro y fuera del subsistema. De los resultados obtenidos destaca la importancia de las relaciones intrasectoriales del subsistema agroalimentario, que muestra una relevante autonomía en cuanto a este tipo de emisiones respecto al resto de la economía. Esta característica orienta el tipo de políticas medioambientales a implementar con el objetivo de reducir el impacto atmosférico de dicha actividad.

Análisis multi-región input-output (MRIO) de emisiones de gases efecto invernadero (GEI) incorporado en el comercio. Un modelo birregional aplicado a Cataluña y el resto de España

El siguiente trabajo realiza un análisis regional y sectorial para el estudio de la emisiones de gases efecto invernadero (GEI) incorporadas en el comercio entre las regiones de Cataluña y el resto de España para el año 2001, estimando así el Balance Neto en GEI incorporado. El objetivo es el desarrollo de un metodología que nos permita realizar esta estimación de forma rigurosa, con la intención de efectuar un análisis comparativo de ambas estructuras productivas territoriales, en cuanto a la intensidad de emisión y el impacto de la demanda final de las regiones consideradas. Para este propósito se utiliza el marco metodológico del análisis input-output, en particular se aplica dos tipologías de modelos: el modelo básico o single-región y el multi-región, lo que nos permite la comparabilidad entre ambos, demostrando como el modelo MRIO (multi-región input-output) es el método más apropiado para dicho propósito, permitiendo, entre otras ventajas, analizar los vínculos interregionales e intersectoriales de las regiones consideradas. La incorporación de la técnica de la integración vertical o subsistemas, nos permite un enfoque alternativo para el Balance Neto resultante, no tenemos constancia de que este enfoque haya sido utilizado con anterioridad en los análisis MRIO aplicados al estudio de los impactos medioambientales incorporados en el comercio. Tampoco la tenemos sobre la aplicación de los MRIO de forma general para estos impactos a nivel interregional de la economía española. El principal resultado obtenido nos indica que aún teniendo Cataluña un importante superávit comercial con el resto de España, hemos comprobado la existencia de un importante déficit para la primera en cuanto a la polución incorporada en este comercio.

Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.

Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus nephritis. Inbred mouse strains differ in susceptibility to anti-GBM antibody-induced and spontaneous lupus nephritis. This study sought to clarify the genetic and molecular factors that maybe responsible for enhanced immune-mediated renal disease in these models. When the kidneys of 3 mouse strains sensitive to anti-GBM antibody-induced nephritis were compared with those of 2 control strains using microarray analysis, one-fifth of the underexpressed genes belonged to the kallikrein gene family,which encodes serine esterases. Mouse strains that upregulated renal and urinary kallikreins exhibited less evidence of disease. Antagonizing the kallikrein pathway augmented disease, while agonists dampened the severity of anti-GBM antibody-induced nephritis. In addition, nephritis-sensitive mouse strains had kallikrein haplotypes that were distinct from those of control strains, including several regulatory polymorphisms,some of which were associated with functional consequences. Indeed, increased susceptibility to anti-GBM antibody-induced nephritis and spontaneous lupus nephritis was achieved by breeding mice with a genetic interval harboring the kallikrein genes onto a disease-resistant background. Finally, both human SLE and spontaneous lupus nephritis were found to be associated with kallikrein genes, particularly KLK1 and the KLK3 promoter, when DNA SNPs from independent cohorts of SLE patients and controls were compared. Collectively, these studies suggest that kallikreins are protective disease-associated genes in anti-GBM antibody-induced nephritis and lupus.

HLA and non-HLA genes in Behçet's disease: a multicentric study in the Spanish population.

INTRODUCTION According to genome wide association (GWA) studies as well as candidate gene approaches, Behçet's disease (BD) is associated with human leukocyte antigen (HLA)-A and HLA-B gene regions. The HLA-B51 has been consistently associated with the disease, but the role of other HLA class I molecules remains controversial. Recently, variants in non-HLA genes have also been associated with BD. The aims of this study were to further investigate the influence of the HLA region in BD and to explore the relationship with non-HLA genes recently described to be associated in other populations. METHODS This study included 304 BD patients and 313 ethnically matched controls. HLA-A and HLA-B low resolution typing was carried out by PCR-SSOP Luminex. Eleven tag single nucleotide polymorphisms (SNPs) located outside of the HLA-region, previously described associated with the disease in GWA studies and having a minor allele frequency in Caucasians greater than 0.15 were genotyped using TaqMan assays. Phenotypic and genotypic frequencies were estimated by direct counting and distributions were compared using the χ(2) test. RESULTS In addition to HLA-B*51, HLA-B*57 was found as a risk factor in BD, whereas, B*35 was found to be protective. Other HLA-A and B specificities were suggestive of association with the disease as risk (A*02 and A*24) or protective factors (A*03 and B*58). Regarding the non-HLA genes, the three SNPs located in IL23R and one of the SNPs in IL10 were found to be significantly associated with susceptibility to BD in our population. CONCLUSION Different HLA specificities are associated with Behçet's disease in addition to B*51. Other non-HLA genes, such as IL23R and IL-10, play a role in the susceptibility to the disease.

Vicent Garcia, poeta europeu

Si hi ha un període postmedieval similar al nostre d’avui en la història literària catalana en el qual els nostres escriptors -trencant radicalment amb una tradició ja obsoleta (com era la del cinc-cents en la seva major part)- es posen a l’alçada dels corrents literaris europeus, aquest és el període barroc (cf. Rossich 1984 ). El text que em proposo analitzar i comparar il·lustra perfectament aquesta circumstància

La Obra de Cayetano Garviso: 1807- post. 1871: cirujano vasco-navarro liberal en América

L'autor d'aquest llibre dona a conèixer alguns aspectes de l'exercici de la medicina en la dècada de 1840 a la zona del Río de la Plata, a partir de la figura del metge basc-navarrés Cayetano Garviso, cirurgià que emigrà a Argentina durant la Primera Guerra Carlista. Ara bé, tot i que aquest personatge es va moure per bona part de Sudamèrica, el treball es centra en la part de la seva biografia i el seu exercici professional desenvolupada a Espanya, Montevideo i Buenos Aires.

Vicent Martines, El «Tirant» poliglota. Estudi sobre el «Tirant lo Blanch» a partir de les seues traduccions espanyola, italiana i francesa deIs segles XVI-XVIII

Ressenya de l'obra: Vicent MARTINES, El «Tirant» poliglota. Estudi sobre el «Tirant lo Blanch» a partir de les seues traduccions espanyola, italiana ifrancesa dels segles XVI-XVIII. Barcelona: Curial Edicions Catalanes. Publicacions de l'Abadia de Montserrat, 1997. Col. "Textos i Estudis de Cultura Catalana", 55. 206 p.

De València a Vannes: culte, devoció i relíquies de Sant Vicent Ferrer

Saint Vicent Ferrer’s personality (1350-1419) has been tackled by researchers in different points of view, and this has meant a proliferation of very diverse studies. There isn’t much, however, the works which has done analysis relating to popular piety and devotion. In this sense, the different hagiographic sources puts us faced with a saint with a very widespread cult in some areas, for instance, the Crown of Aragon and Castille, but also in other european places. As for the last, we detect an import focus of devotion in Brittany, where the saint arrived to preach after being called by Jean V. He died at Vannes (1419), the political capital of the duchy of Brittany, and he was buried in Saint Pierre’s cathedral. Previously to his canonization, his fame as a miracle worker during his life was the reason for his tomb became a real locus sanctus, a place where pilgrims arrived to venerate his relics. These relics had healing and prophylactic properties. Apart from these ones, we have many references of “contact relics” with properties of this kind.

Francesc Vicent Garcia i el Barroc hispànic

Sobre la particularietat del Barroc català i de l'obra de Francesc Vicent Garcia dins el panorama de la literatura hispànica i el tractament que n'ha fet la historiografia literària

Poemas de Santa Teresa. Antología a cargo de Rosa Navarro

Teresa de Jesús era una prosista excepcional; su primer editor, el gran humanista fray Luis de León, supo señalar muy bien 'la elegancia desafeitada que deleita en extremo' de su escritura.

Dimorfismo sexual durante el desarrollo del pulmón fetal del ratón albino : estudio morfológico y bioquímico (por) Rosa Patricia Penilla Navarro

Tesis (Maestría en Ciencias, con especialidad en Morfología)U.A.N.L.