Contuse lesion of the rat spinal cord of moderate intensity leads to a higher time-dependent secondary neurodegeneration than severe one - An open-window for experimental neuroprotective interventions

Secondary neurodegeneration takes place in the surrounding tissue of spinal cord trauma and modifies substantially the prognosis, considering the small diameter of its transversal axis. We analyzed neuronal and glial responses in rat spinal cord after different degree of contusion promoted by the NYU Impactor. Rats were submitted to vertebrae laminectomy and received moderate or severe contusions. Control animals were sham operated. After 7 and 30 days post surgery, stereological analysis of Nissl staining cellular profiles showed a time progression of the lesion volume after moderate injury, but not after severe injury. The number of neurons was not altered cranial to injury. However, same degree of diminution was seen in the caudal cord 30 days after both severe and moderate injuries. Microdensitometric image analysis demonstrated a microglial reaction in the white matter 30 days after a moderate contusion and showed a widespread astroglial reaction in the white and gray matters 7 days after both severities. Astroglial activation lasted close to lesion and in areas related to Wallerian degeneration. Data showed a more protracted secondary degeneration in rat spinal cord after mild contusion, which offered an opportunity for neuroprotective approaches. Temporal and regional glial responses corroborated to diverse glial cell function in lesioned spinal cord. (C) 2007 Elsevier Ltd. All rights reserved.

Time-related effects of general functional training in spinal cord-injured rats

OBJECTIVES: This prospective, randomized, experimental study with rats aimed to investigate the influence of general treatment strategies on the motor recovery of Wistar rats with moderate contusive spinal cord injury. METHODS: A total of 51 Wistar rats were randomized into five groups: control, maze, ramp, runway, and sham (laminectomy only). The rats underwent spinal cord injury at the T9-T10 levels using the NYU-Impactor. Each group was trained for 12 minutes twice a week for two weeks before and five weeks after the spinal cord injury, except for the control group. Functional motor recovery was assessed with the Basso, Beattie, and Bresnahan Scale on the first postoperative day and then once a week for five weeks. The animals were euthanized, and the spinal cords were collected for histological analysis. RESULTS: Ramp and maze groups showed an earlier and greater functional improvement effect than the control and runway groups. However, over time, unexpectedly, all of the groups showed similar effects as the control group, with spontaneous recovery. There were no histological differences in the injured area between the trained and control groups. CONCLUSION: Short-term benefits can be associated with a specific training regime; however, the same training was ineffective at maintaining superior long-term recovery. These results might support new considerations before hospital discharge of patients with spinal cord injuries.

Ṿi azoy lebn Poylishe Yidn in di geṭos : geleyenṭ oyf der 16ṭer yoriḳer ḳonferenz fun Yidishn Ṿisenshaftlekhn Insṭiṭuṭ, Nyu-Yorḳ, dem 11ṭn Yanuʾar 1942

Shloyme Mendelson

A non-deformable crabbed impactor into a 1990 Honda Civic SI in support of CRASH3 damage algorithm reformulation. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

A non-deformable crabbed impactor into a 1988 Ford Taurus 4-door sedan in support of CRASH3 damage algorithm reformulation. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Side impact sub-system test development: MVMA thoracic impactor test procedure and evaluation. Final report.

Mode of access: Internet.

Direct support and general support maintenance manual for tractor, wheeled, DED, loader backhoe, with hydraulic impact tool and with hydraulic earth auger attachment, John Deere model JD410 (CCE), with bucket, impactor, and earth drill (NSN 2420-00-567-0135).

"August 1992."

Operator's manual : tractor, wheeled (DED) loader backhoe w/hydraulic impact tool and w/hydraulic earth auger attachment, John Deere model JD410 (CCE), w/Wain-Roy Bucket, Hughes Impactor and Danuser Earth Drill, (NSN 2420-00-567-0135).

Includes index.

Organizational maintenance manual : tractor, wheeled (DED) loader backhoe w/hydraulic impact tool and w/hydraulic earth auger attachment, John Deere model JD410 (CCE), w/Wain-Roy Bucket, Hughes Impactor and Danuser Earth Drill, (NSN 2420-00-567-0135).

Includes indexes.

Organizational maintenance, repair parts and special tools lists : tractor, wheeled, DED, loader backhoe w/hydraulic impact tool and w/hydraulicearth auger attachment w/Wain-Roy bucket, Hughs impactor and Danuser earth drillNSN 2420-00-567-0135.

Includes index.

Unit maintenance, repair parts, and special tools lists : tractor, wheeled, DED, loader backhoe with hydraulic impact tool and with hydraulic earth auger attachment, John Deere model JD410 (CCE), with bucket, impactor, and earth drill, NSN 2420-00-567-0135.

"February 1992."

NYU law students reply with hangers to Secretary of Health, Education, and Welfare Joseph A. Califano's stance on "Medicaid for Abortions"

General note: Title and date provided by Bettye Lane.