Exploring the association of diary product intake with the fatty acids C15:0 and C17:0 measured from dried blood spots in a multi-population cohort: findings from the Food4Me study

Scope: The use of biomarkers in the objective assessment of dietary intake is a high priority in nutrition research. The aim of this study was to examine pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) as biomarkers of dairy foods intake. Methods and results: The data used in the present study were obtained as part of the Food4me Study. Estimates of C15:0 and C17:0 from dried blood spots and intakes of dairy from an FFQ were obtained from participants (n=1,180) across 7 countries. Regression analyses were used to explore associations of biomarkers with dairy intake levels and receiver operating characteristic (ROC) analyses were used to evaluate the fatty acids. Significant positive associations were found between C15:0 and total intakes of high-fat dairy products. C15:0 showed good ability to distinguish between low and high consumers of high-fat dairy products. Conclusion: C15:0 can be used as a biomarker of high-fat dairy intake and of specific high-fat dairy products. Both C15:0 and C17:0 performed poorly for total dairy intake highlighting the need for caution when using these in epidemiological studies.

Multi-population genetic algorithm to solve the synchronized and integrated two-level lot sizing and scheduling problem

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A hybrid multi-population genetic algorithm applied to solve the multi-level capacitated lot sizing problem with backlogging

The present paper proposes a new hybrid multi-population genetic algorithm (HMPGA) as an approach to solve the multi-level capacitated lot sizing problem with backlogging. This method combines a multi-population based metaheuristic using fix-and-optimize heuristic and mathematical programming techniques. A total of four test sets from the MULTILSB (Multi-Item Lot-Sizing with Backlogging) library are solved and the results are compared with those reached by two other methods recently published. The results have shown that HMPGA had a better performance for most of the test sets solved, specially when longer computing time is given. © 2012 Elsevier Ltd.

FPGA implementation of a multi-population PBIL algorithm

Evolutionary-based algorithms play an important role in finding solutions to many problems that are not solved by classical methods, and particularly so for those cases where solutions lie within extreme non-convex multidimensional spaces. The intrinsic parallel structure of evolutionary algorithms are amenable to the simultaneous testing of multiple solutions; this has proved essential to the circumvention of local optima, and such robustness comes with high computational overhead, though custom digital processor use may reduce this cost. This paper presents a new implementation of an old, and almost forgotten, evolutionary algorithm: the population-based incremental learning method. We show that the structure of this algorithm is well suited to implementation within programmable logic, as compared with contemporary genetic algorithms. Further, the inherent concurrency of our FPGA implementation facilitates the integration and testing of micro-populations.

Evolutionary optimization and game strategies for advanced multi-disciplinary design : applications to aeronautics and UAV design

Many complex aeronautical design problems can be formulated with efficient multi-objective evolutionary optimization methods and game strategies. This book describes the role of advanced innovative evolution tools in the solution, or the set of solutions of single or multi disciplinary optimization. These tools use the concept of multi-population, asynchronous parallelization and hierarchical topology which allows different models including precise, intermediate and approximate models with each node belonging to the different hierarchical layer handled by a different Evolutionary Algorithm. The efficiency of evolutionary algorithms for both single and multi-objective optimization problems are significantly improved by the coupling of EAs with games and in particular by a new dynamic methodology named “Hybridized Nash-Pareto games”. Multi objective Optimization techniques and robust design problems taking into account uncertainties are introduced and explained in detail. Several applications dealing with civil aircraft and UAV, UCAV systems are implemented numerically and discussed. Applications of increasing optimization complexity are presented as well as two hands-on test cases problems. These examples focus on aeronautical applications and will be useful to the practitioner in the laboratory or in industrial design environments. The evolutionary methods coupled with games presented in this volume can be applied to other areas including surface and marine transport, structures, biomedical engineering, renewable energy and environmental problems.

A multiple population genetic algorithm and its application in fuzzy controller

Genetic Algorithm is an important optimization technique, though its application in Fuzzy system is usually limited by problems like local optimal and premature convergence. With an aim to improve the performance of simple Genetic Algorithm, we propose a multi-population genetic algorithm MP-GA which uses two populations collaborating with each other, and apply it to fuzzy controller design to optimize its control rules. The simulation results of Inverted Pendulum demonstrate the effectiveness of this proposed method.

Evaluating genetic algorithms with different population structures on a lot sizing and scheduling problem

This paper studies the use of different population structures in a Genetic Algorithm (GA) applied to lot sizing and scheduling problems. The population approaches are divided into two types: single-population and multi-population. The first type has a non-structured single population. The multi-population type presents non-structured and structured populations organized in binary and ternary trees. Each population approach is tested on lot sizing and scheduling problems found in soft drink companies. These problems have two interdependent levels with decisions concerning raw material storage and soft drink bottling. The challenge is to simultaneously determine the lot sizing and scheduling of raw materials in tanks and products in lines. Computational results are reported allowing determining the better population structure for the set of problem instances evaluated. Copyright 2008 ACM.

Methods used in cross-cultural comparisons of vasomotor symptoms and their determinants

Methodological differences among studies of vasomotor symptoms limit rigorous comparison or systematic review. Vasomotor symptoms generally include hot flushes and night sweats although other associated symptoms exist. Prevalence rates vary between and within populations, but different studies collect data on frequency, bothersomeness, and/or severity using different outcome measures and scales, making comparisons difficult. We reviewed only cross-cultural studies of menopausal symptoms that explicitly examined symptoms in general populations of women in different countries or different ethnic groups in the same country. This resulted in the inclusion of nine studies: Australian/Japanese Midlife Women's Health Study (AJMWHS), Decisions At Menopause Study (DAMeS), Four Major Ethnic Groups (FMEG), Hilo Women's Health Survey (HWHS), Mid-Aged Health in Women from the Indian Subcontinent (MAHWIS), Penn Ovarian Aging Study (POAS), Study of Women's Health Across the Nation (SWAN), Women's Health in Midlife National Study (WHiMNS), and Women's International Study of Health and Sexuality (WISHeS). These studies highlight the methodological challenges involved in conducting multi-population studies, particularly when languages differ, but also highlight the importance of performing multivariate and factor analyses. Significant cultural differences in one or more vasomotor symptoms were observed in 8 of 9 studies, and symptoms were influenced by the following determinants: menopausal status, hormones (and variance), age (or actually, the square of age, age2), BMI, depression, anxiety, poor physical health, perceived stress, lifestyle factors (hormone therapy use, smoking and exposure to passive smoke), and acculturation (in immigrant populations). Recommendations are made to improve methodological rigor and facilitate comparisons in future cross-cultural menopause studies.

Hierarchical robust design optimisation of shock control bump devices for airfoil drag reduction

The paper investigates a detailed Active Shock Control Bump Design Optimisation on a Natural Laminar Flow (NLF) aerofoil; RAE 5243 to reduce cruise drag at transonic flow conditions using Evolutionary Algorithms (EAs) coupled to a robust design approach. For the uncertainty design parameters, the positions of boundary layer transition (xtr) and the coefficient of lift (Cl) are considered (250 stochastic samples in total). In this paper, two robust design methods are considered; the first approach uses a standard robust design method, which evaluates one design model at 250 stochastic conditions for uncertainty. The second approach is the combination of a standard robust design method and the concept of hierarchical (multi-population) sampling (250, 50, 15) for uncertainty. Numerical results show that the evolutionary optimization method coupled to uncertainty design techniques produces useful and reliable Pareto optimal SCB shapes which have low sensitivity and high aerodynamic performance while having significant total drag reduction. In addition,it also shows the benefit of using hierarchical robust method for detailed uncertainty design optimization.

A GA-PSO layered encoding evolutionary approach to 0/1 knapsack optimization

This paper presents a layered encoding cascade evolutionary approach to solve a 0/1 knapsack optimization problem. A layered encoding structure is proposed and developed based on the schema theorem and the concepts of cascade correlation and multi-population evolutionary algorithms. Genetic algorithm (GA) and particle swarm optimization (PSO) are combined with the proposed layered encoding structure to form a generic optimization model denoted as LGAPSO. In order to enhance the finding of both local and global optimum in the evolutionary search, the model adopts hill climbing evaluation criteria, feature of strength Pareto evolutionary approach (SPEA) as well as nondominated spread lengthen criteria. Four different sizes benchmark knapsack problems are studied using the proposed LGAPSO model. The performance of LGAPSO is compared to that of the ordinary multi-objective optimizers such as VEGA, NSGA, NPGA and SPEA. The proposed LGAPSO model is shown to be efficient in improving the search of knapsack’s optimum, capable of gaining better Pareto trade-off front.

Evolutionary optimization: a big data perspective

Stochastic search techniques such as evolutionary algorithms (EA) are known to be better explorer of search space as compared to conventional techniques including deterministic methods. However, in the era of big data like most other search methods and learning algorithms, suitability of evolutionary algorithms is naturally questioned. Big data pose new computational challenges including very high dimensionality and sparseness of data. Evolutionary algorithms' superior exploration skills should make them promising candidates for handling optimization problems involving big data. High dimensional problems introduce added complexity to the search space. However, EAs need to be enhanced to ensure that majority of the potential winner solutions gets the chance to survive and mature. In this paper we present an evolutionary algorithm with enhanced ability to deal with the problems of high dimensionality and sparseness of data. In addition to an informed exploration of the solution space, this technique balances exploration and exploitation using a hierarchical multi-population approach. The proposed model uses informed genetic operators to introduce diversity by expanding the scope of search process at the expense of redundant less promising members of the population. Next phase of the algorithm attempts to deal with the problem of high dimensionality by ensuring broader and more exhaustive search and preventing premature death of potential solutions. To achieve this, in addition to the above exploration controlling mechanism, a multi-tier hierarchical architecture is employed, where, in separate layers, the less fit isolated individuals evolve in dynamic sub-populations that coexist alongside the original or main population. Evaluation of the proposed technique on well known benchmark problems ascertains its superior performance. The algorithm has also been successfully applied to a real world problem of financial portfolio management. Although the proposed method cannot be considered big data-ready, it is certainly a move in the right direction.

An equilibrium approach to modelling social interaction

The aim of this work is to put forward a statistical mechanics theory of social interaction, generalizing econometric discrete choice models. After showing the formal equivalence linking econometric multinomial logit models to equilibrium statical mechanics, a multi- population generalization of the Curie-Weiss model for ferromagnets is considered as a starting point in developing a model capable of describing sudden shifts in aggregate human behaviour. Existence of the thermodynamic limit for the model is shown by an asymptotic sub-additivity method and factorization of correlation functions is proved almost everywhere. The exact solution for the model is provided in the thermodynamical limit by nding converging upper and lower bounds for the system's pressure, and the solution is used to prove an analytic result regarding the number of possible equilibrium states of a two-population system. The work stresses the importance of linking regimes predicted by the model to real phenomena, and to this end it proposes two possible procedures to estimate the model's parameters starting from micro-level data. These are applied to three case studies based on census type data: though these studies are found to be ultimately inconclusive on an empirical level, considerations are drawn that encourage further refinements of the chosen modelling approach, to be considered in future work.

Parameter Identification of a Fed-Batch Cultivation of S. Cerevisiae using Genetic Algorithms

Fermentation processes as objects of modelling and high-quality control are characterized with interdependence and time-varying of process variables that lead to non-linear models with a very complex structure. This is why the conventional optimization methods cannot lead to a satisfied solution. As an alternative, genetic algorithms, like the stochastic global optimization method, can be applied to overcome these limitations. The application of genetic algorithms is a precondition for robustness and reaching of a global minimum that makes them eligible and more workable for parameter identification of fermentation models. Different types of genetic algorithms, namely simple, modified and multi-population ones, have been applied and compared for estimation of nonlinear dynamic model parameters of fed-batch cultivation of S. cerevisiae.