An obituary memoir of Robert F. Mott : read before two literary societies to which he belonged /

Published at the joint request of the Society of Teachers (New York) and the Calliopean Society.

A lecture, on classical & national education; delivered December 28, 1825, in the chapel of Nassau Hall, before the Literary & Philosophical Society of New Jersey. ...

Mode of access: Internet.

Léopold Robert d'après sa correspondance inédite,

Mode of access: Internet.

Therapeutic effects of PPARα agonists on diabetic retinopathy in type 1 diabetes models

Retinal vascular leakage, inflammation, and neovascularization (NV) are features of diabetic retinopathy (DR). Fenofibrate, a peroxisome proliferator-activated receptor a (PPARa) agonist, has shown robust protective effects against DR in type 2 diabetic patients, but its effects on DR in type 1 diabetes have not been reported. This study evaluated the efficacy of fenofibrate on DR in type 1 diabetes models and determined if the effect is PPARa dependent. Oral administration of fenofibrate significantly ameliorated retinal vascular leakage and leukostasis in streptozotocin-induced diabetic rats and in Akita mice. Favorable effects on DR were also achieved by intravitreal injection of fenofibrate or another specific PPARa agonist. Fenofibrate also ameliorated retinal NV in the oxygen-induced retinopathy (OIR) model and inhibited tube formation and migration in cultured endothelial cells. Fenofibrate also attenuated overexpression of intercellular adhesion molecule-1, monocyte chemoattractant protein-1, and vascular endothelial growth factor (VEGF) and blocked activation of hypoxia-inducible factor-1 and nuclear factor-?B in the retinas of OIR and diabetic models. Fenofibrate's beneficial effects were blocked by a specific PPARa antagonist. Furthermore, Ppara knockout abolished the fenofibrate-induced downregulation of VEGF and reduction of retinal vascular leakage in DR models. These results demonstrate therapeutic effects of fenofibrate on DR in type 1 diabetes and support the existence of the drug target in ocular tissues and via a PPARa-dependent mechanism.

Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models

Although Wnt signaling is known to mediate multiple biological and pathological processes, its association with diabetic retinopathy (DR) has not been established. Here we show that retinal levels and nuclear translocation of beta-catenin, a key effector in the canonical Wnt pathway, were increased in humans with DR and in three DR models. Retinal levels of low-density lipoprotein receptor-related proteins 5 and 6, coreceptors of Wnts, were also elevated in the DR models. The high glucose-induced activation of beta-catenin was attenuated by aminoguanidine, suggesting that oxidative stress is a direct cause for the Wnt pathway activation in diabetes. Indeed, Dickkopf homolog 1, a specific inhibitor of the Wnt pathway, ameliorated retinal inflammation, vascular leakage, and retinal neovascularization in the DR models. Dickkopf homolog 1 also blocked the generation of reactive oxygen species induced by high glucose, suggesting that Wnt signaling contributes to the oxidative stress in diabetes. These observations indicate that the Wnt pathway plays a pathogenic role in DR and represents a novel therapeutic target.

A new Greek and English lexicon; principally on the plan of the Greek and German lexicon of Schneider.

Mode of access: Internet.

Historical and descriptive account of British India, from the most remote period to the present time: including a narrative of the early Portuguese and English voyages, the revolutions in the Mogul empire, and the ... establishment of the British power;

Added title-pages, engr.

The unnoticed theories of Servetus, a dissertation addressed to the Medical society of Stockholm.

Dissertation in Latin, with special t.-p.: Dissertatio, quædam de Serveto complectens quam Societati medicæ apud Stockholm subjicit Georgius Sigmond ...

The song of the patriot, sonnets and songs /

List of subscribers: p. [xiii]-xiv.

A collection of fragments illustrative of the history and antiquities of Derby,

Mode of access: Internet.

An attempt to explain from facts the effect of the issues of the Bank of England upon its own interests, public credit, and country banks.

Mode of access: Internet.

Algae britannicae : or, Descriptions of the marine and other inarticulated plants of the British Islands, belonging to the order Algae /

Includes bibliographical references and index

Scottish cryptogamic flora, or Coloured figures and descriptions of cryptogamic plants, belonging chiefly to the order Fungi; and intended to serve as a continuation of English botany.

Mode of access: Internet.

Observations on the structure and affinities of the more remarkable plants : collected by the late Walter Oudney and Major Denham and Captain Clapperton in the years 1822, 1823, and 1824, during their expedition to explore Central Africa.

"Printed as the Botanical appendix to the Narrative of travels and discoveries in Northern and Central Africa."