Miniaturization in Otothyris Myers, 1927 (Loricariidae: Hypoptopomatinae)

Muitas espécies de peixes de água doce são consideradas miniaturas, entretanto, sua identificação é frequentemente baseada apenas no critério arbitrário que é seu reduzido tamanho corporal. Apesar de algumas espécies de Otothyris terem sido propostas como miniaturas, informações acerca do processo de miniaturização no gênero e suas consequências são escassas. Aqui detalhamos eventos de perda, fusão, modificações em muitos ossos, sistema laterossensorial e no cérebro, que juntos evidenciam a miniaturização em todas as espécies do gênero. Nossos resultados podem ser úteis na identificação de outras espécies miniaturas dentro de Loricariidae.

Chronic Telogen Effluvium And Female Pattern Hair Loss Are Separate And Distinct Forms Of Alopecia: A Histomorphometric And Immunohistochemical Analysis.

Chronic telogen effluvium (CTE), a poorly understood condition, can be confused with or may be a prodrome to female pattern hair loss (FPHL). The pathogenesis of both is related to follicle cycle shortening and possibly to blood supply changes. To analyze a number of histomorphometric and immunohistochemical findings through vascular endothelial growth factor (VEGF), Ki-67, and CD31 immunostaining in scalp biopsies of 20 patients with CTE, 17 patients with mild FPHL and 9 controls. Ki-67 index and VEGF optical density were analyzed at the follicular outer sheath using ImageJ software. CD31 microvessel density was assessed by a Chalkley grid. Significant follicle miniaturization and higher density of nonanagen follicles were found in FPHL, compared with patients with CTE and controls. Ki-67+ index correlated positively with FPHL histological features. The FPHL group showed the highest VEGF optical density, followed by the CTE and control groups. No differences were found in CD31 microvessel density between the three groups. Histomorphometric results establish CTE as a distinct disorder, separate from FPHL from its outset. Its pathogenic mechanisms are also distinct. These findings support the proposed mechanism of 'immediate telogen release' for CTE, leading to cycle synchronization. For FPHL, accelerated anagen follicular mitotic rates and, thus, higher Ki-67 and VEGF values, would leave less time for differentiation, resulting in hair miniaturization.

Design and Characterization of a Biomimetic Piezoelectric Pump Inspired on Group Fish Swimming Effect

Flow pumps are important tools in several engineering areas, such as in the fields of bioengineering and thermal management solutions for electronic devices. Nowadays, many of the new flow pump principles are based on the use of piezoelectric actuators, which present some advantages such as miniaturization potential and lower noise generation. In previous work, authors presented a study of a novel pump configuration based on placing an oscillating bimorph piezoelectric actuator in water to generate flow. It was concluded that this oscillatory behavior (such as fish swimming) yields vortex interaction, generating flow rate due to the action and reaction principle. Thus, following this idea the objective of this work is to explore this oscillatory principle by studying the interaction among generated vortex from two bimorph piezoelectric actuators oscillating inside the same pump channel, which is similar to the interaction of vortex generated by frontal fish and posterior ones when they swim together in a group formation. It is shown that parallel-series configurations of bimorph piezoelectric actuators inside the same pump channel provide higher flow rates and pressure for liquid pumping than simple parallel-series arrangements of corresponding single piezoelectric pumps, respectively. The scope of this work includes structural simulations of bimorph piezoelectric actuators, fluid flow simulations, and prototype construction for result validation.

A biomimetic piezoelectric pump: Computational and experimental characterization

Flow pumps have been developed for classical applications in Engineering, and are important instruments in areas such as Biology and Medicine. Among applications for this kind of device we notice blood pump and chemical reagents dosage in Bioengineering. Furthermore, they have recently emerged as a viable thermal management solution for cooling applications in small-scale electronic devices. This work presents the performance study of a novel principle of a piezoelectric flow pump which is based oil the use of a bimorph piezoelectric actuator inserted in fluid (water). Piezoelectric actuators have some advantages over classical devices, such as lower noise generation and ease of miniaturization. The main objective is the characterization of this piezoelectric pump principle through computational simulations (using finite element software), and experimental tests through a manufactured prototype. Computational data, Such as flow rate and pressure curves, have also been compared with experimental results for validation purposes. (C) 2009 Elsevier B.V. All rights reserved.

Comparison of adsorbent films obtained by plasma polymerization of oxygenated organic compounds

Thin films obtained by plasma polymerization of ethyl ether, methyl or ethyl acetate, acetaldehyde, acetone and 2-propanol were compared. Infrared spectroscopy (FFIR), resistance to chemicals, contact angle measurements, X-ray photoelectron spectroscopy (XPS), optical and scanning electron microscopy (SEM), and quartz crystal microbalance (QCM) were carried out. For all films FTIR showed high intensity for polar bonds yet the films are not resistant to polar solvents. Contact angle measurements revealed hydrophilic and organophilic surfaces and XPS pointed out a high proportion of oxygenated bonds. All films showed good step coverage and peeling was significant only with acetone and 2-propanol. All films are adsorbent for organic compounds in a large scale of polarity but acetaldehyde and 2-propanol act like a selective membrane. Also, deposition of these films on hydrophobic substrates leads to island formation. A possible model to explain the results must consider the hydrogen bridge formation on 2-propanol and acetaldehyde films. Ethyl ether, ethyl and methyl acetate showed good characteristics for development of sensor and sample pretreatment using miniaturized devices. (C) 2007 Elsevier B.V. All rights reserved.

Miniaturized structures for removal or selection of particles from liquid flow

The aim of this work was the development of miniaturized structures useful for retention and/or selection of particles and viscous substances from a liquid flow. The proposed low costs structures are similar to macroscopic wastewater treatment systems, named baffles, and allow disassemble. They were simulated using FEMLAB 3.2b package and manufactured in acrylic with conventional tools. Tests for retention or selection of particles in water or air and viscous fluids in water were carried out. Either in air or water particles with 50 mu m diameter will be retained but not with 13 mu m diameter. In aqueous flow, it is also possible the retention of viscous samples, such as silicone 350 cSt. The simulated results showed good agreement with experimental measurements. These miniaturized structures can be useful in sample pretreatment for chemical analysis and microorganism manipulation. (C) 2007 Elsevier B.V. All rights reserved.

Limiting Internal Supply Voltage Spikes in DC-DC Converters

Implementing monolithic DC-DC converters for low power portable applications with a standard low voltage CMOS technology leads to lower production costs and higher reliability. Moreover, it allows miniaturization by the integration of two units in the same die: the power management unit that regulates the supply voltage for the second unit, a dedicated signal processor, that performs the functions required. This paper presents original techniques that limit spikes in the internal supply voltage on a monolithic DC-DC converter, extending the use of the same technology for both units. These spikes are mainly caused by fast current variations in the path connecting the external power supply to the internal pads of the converter power block. This path includes two parasitic inductances inbuilt in bond wires and in package pins. Although these parasitic inductances present relative low values when compared with the typical external inductances of DC-DC converters, their effects can not be neglected when switching high currents at high switching frequency. The associated overvoltage frequently causes destruction, reliability problems and/or control malfunction. Different spike reduction techniques are presented and compared. The proposed techniques were used in the design of the gate driver of a DC-DC converter included in a power management unit implemented in a standard 0.35 mu m CMOS technology.

Reconfigurable antenna for mobile devices

O trabalho descrito nesta dissertação de mestrado foca-se em geral na investigação de antenas impressas. São apresentados conceitos básicos, em conjunto com alguns exemplos desenvolvidos. No entanto, o principal foco prende-se com técnicas de miniaturização e reconfigurabilidade de antenas. A miniaturização de antenas é um tema de investigação de longa data, no entanto, novas técnicas e soluções são apresentadas regularmente. Nesta tese, é aplicada uma técnica recente, baseada na introdução de indutores encapsulados no elemento ressonante de uma antena, que permite miniaturizar um monopólio impresso com uma frequência de ressonância de 2.5 GHz. Outro assunto abordado neste trabalho é a reconfigurabilidade de antenas. Algumas das técnicas mais comuns na investigação actual são apresentadas e debatidas. Uma solução com recurso a díodos PIN é usada para estudar esta capacidade. Os conceitos e características deste tipo de componentes são apresentadas sendo feito o desenho e fabrico de um possível monopólio impresso reconfigurável para operação em dupla banda. Por fim, são combinadas as técnicas de miniaturização com inductor encapsulado e reconfigurabilidade através de díodos PIN, por forma a projectar uma antena reconfigurável muito pequena, para operação em duas bandas distintas. Os resultados são discutidos e com base nestes, algumas possíveis otimizações são propostas. The work reported in this dissertation is focused in the printed antenna research. Basic concepts of printed antennas are presented, along with a few examples that were developed. The main focus however, is around miniaturization and reconfigurability of antennas. Antenna miniaturization is a long time research subject, however, new techniques and solutions are presented everyday. In this thesis, a recent technique based on the introduction of chip inductors in the resonating element of a printed antenna is used in order to miniaturize a monopole with a resonating frequency at 2.5 GHz. Another issue approached in this work is antenna reconfigurability. Some common techniques used in antenna reconfiguration are presented and debated. A solution with PIN diodes is used to study this capability. The concepts and characteristics of this type of components are presented and an example of a reconfigurable printed monopole for dual-band operation is designed and fabricated. At last, miniaturization with chip inductor and reconfigurability through PIN diodes are used together to create a very small antenna for dual-band operation. The simulated and measured results are discussed and upon these, some possible optimizations are proposed.

Análise e implementação de filtros e controladores num sistema de processamento digital de sinal

Dissertação para obtenção do grau de Mestre em Engenharia Electrotécnica Ramo de Automação e Electrónica Industrial

Enhanced Race-to-halt: a leakage-aware energy management approach for dynamic priority systems

With progressing CMOS technology miniaturization, the leakage power consumption starts to dominate the dynamic power consumption. The recent technology trends have equipped the modern embedded processors with the several sleep states and reduced their overhead (energy/time) of the sleep transition. The dynamic voltage frequency scaling (DVFS) potential to save energy is diminishing due to efficient (low overhead) sleep states and increased static (leakage) power consumption. The state-of-the-art research on static power reduction at system level is based on assumptions that cannot easily be integrated into practical systems. We propose a novel enhanced race-to-halt approach (ERTH) to reduce the overall system energy consumption. The exhaustive simulations demonstrate the effectiveness of our approach showing an improvement of up to 8 % over an existing work.

Compact, frequency reconfigurable, printed monopole antenna

This paper proposes a possible implementation of a compact printed monopole antenna, useful to operate in UMTS and WLAN bands. In order to accomplish that, a miniaturization technique based on the application of chip inductors is used in conjunction with frequency reconfiguration capability. The chip inductors change the impedance response of the monopole, allowing to reduce the resonant frequency. In order to be able to operate the antenna in these two different frequencies, an antenna reconfiguration technique based on PIN diodes is applied. This procedure allows the change of the active form of the antenna leading to a shift in the resonant frequency. The prototype measurements show good agreement with the simulation results.

WeSenseNET - Plataforma de Visualização, Gestão Remota e Agregação Múltipla de Dados

Nos últimos anos, o avanço da tecnologia e a miniaturização de diversos componentes de electrónica associados a novos conceitos têm permitido nascer novas ideias e projectos, que até há alguns anos não passariam de ficção científica. Talvez o exemplo mais acabado seja actualmente o smartphone, um pequeno bloco de hardware e software, com capacidade de processamento que ultrapassa várias vezes o dos computadores com uma dúzia de anos. Estas capacidades têm sido utilizadas em comunicações, blocos de notas, agendas e até entretenimento. No entanto, podem ser reutilizadas para ajudar a resolver algumas limitações/constrangimentos da actualidade. Dentro destes destacam-se a gestão de recursos escassos. Com efeito, o consumo de energia eléctrica tem aumentado como consequência directa do desenvolvimento global e aumento do número de aparelhos eléctricos. Uma percentagem significativa de energia eléctrica tem sido produzida através de recursos não-renováveis de energia. No entanto, a dependência energética, associada à subida de preços e a redução das emissões de gases do efeito estufa, estimula o desenvolvimento de novas soluções que permitam lidar com esta situação. O desempenho energético por sua vez depende não só das características da estrutura, mas também do comportamento do utilizador. O desempenho energético dos edifícios é muito importante, uma vez que os respectivos consumos são responsáveis por mais de metade do total da energia produzida. Desta forma, a fim de alcançar um melhor desempenho é importante não só considerar o desempenho de estrutura, mas também monitorizar o comportamento do utilizador. Esta última questão coloca várias limitações, uma vez que depende muito do tipo de utilizador. Um dos conceitos actuais emergentes são as chamadas redes de sensores sem fio. Com esta tecnologia, pequenos módulos podem ser desenvolvidos com muitas possibilidades de conectividade, com elevado poder de processamento e com grande autonomia, sem serem excessivamente caros. Isto proporciona os meios para implementar vários dispositivos em toda a instalação, para recolher uma variedade de dados, sendo posteriormente armazenados num servidor. Os blocos fundamentais da infra-estrutura de sensores do projecto foram concebidos na Evoleo Technologies em simultâneo com o decorrer do estágio. Estes blocos recolhem dados específicos na instalação, e periodicamente enviam para o servidor central os valores recolhidos, onde são armazenados e colocados à disposição do utilizador. Os dados recolhidos podem então ser apresentados ao utilizador, proporcionando um registo de consumo de energia associado a um dado período de tempo. Uma vez que todos os dados são armazenados no servidor, podem ser efectuados estudos para determinar o uso típico, possíveis problemas em aparelhos, a qualidade da energia eléctrica, etc., permitindo determinar onde a energia está a ser eventualmente desperdiçada e fornecendo dados ao utilizador para que este possa proceder a alterações, tendo por base dados recolhidos num dado período. O objectivo principal deste trabalho passa por estabelecer a ligação entre o nível máquina e o nível de utilizador, isto é, uma plataforma de interacção entre dispositivos e administrador da instalação. Fornecer os dados de uma forma fácil e sem necessidade de instalação de software específico em cada dispositivo que se pretenda utilizar para monitorizar foi uma das principais preocupações das fases de concepção do projecto.

Pulseira inteligente para aplicações industriais e de lazer

Nos últimos anos, o avanço da tecnologia e a miniaturização de diversos componentes têm permitido o aparecimento de novos conceitos, ideias e projetos, que até aqui não passariam de filmes de ficção científica. Com a tecnologia atual, podem ser desenvolvidos pequenos dispositivos wearable com diversas interfaces, múltiplas conectividades, poder de processamento e autonomia. Permitindo desta forma, dar resposta à crescente necessidade de interação com os mais diversos equipamentos eletrónicos do dia-a-dia, melhorando o acesso e o fornecimento de informação. O principal objetivo deste trabalho passa assim por demonstrar e implementar um conceito que permita estreitar e facilitar a interação entre o utilizador e o mundo que o rodeia, quer em ambientes domésticos quer industriais. Para isso foi projetado e implementado um dispositivo wearable (para utilização no pulso) baseado numa arquitetura de hardware e software capaz de correr diferentes aplicações, tais como extensão de alertas de um smartphone, crowdsourcing de informações meteorológicas, manutenção e inspeção industrial e monitorização remota de forças de segurança. Os resultados obtidos demonstram que este conceito é viável tanto do ponto de vista técnico como funcional, evidenciando boas hipóteses para que estes conceitos, métodos e tecnologias possam ser integradas em plataformas robóticas desenvolvidas no âmbito de projetos do Laboratório de Sistemas Autónomos (LSA) bem como nos contextos industrial e de lazer.

Novel LTCC-potentiometric microfluidic device for biparametric analysis of organic compounds carrying plastic antibodies as ionophores: Application to sulfamethoxazole and trimethoprim

Monitoring organic environmental contaminants is of crucial importance to ensure public health. This requires simple, portable and robust devices to carry out on-site analysis. For this purpose, a low-temperature co-fired ceramics (LTCC) microfluidic potentiometric device (LTCC/μPOT) was developed for the first time for an organic compound: sulfamethoxazole (SMX). Sensory materials relied on newly designed plastic antibodies. Sol–gel, self-assembling monolayer and molecular-imprinting techniques were merged for this purpose. Silica beads were amine-modified and linked to SMX via glutaraldehyde modification. Condensation polymerization was conducted around SMX to fill the vacant spaces. SMX was removed after, leaving behind imprinted sites of complementary shape. The obtained particles were used as ionophores in plasticized PVC membranes. The most suitable membrane composition was selected in steady-state assays. Its suitability to flow analysis was verified in flow-injection studies with regular tubular electrodes. The LTCC/μPOT device integrated a bidimensional mixer, an embedded reference electrode based on Ag/AgCl and an Ag-based contact screen-printed under a micromachined cavity of 600 μm depth. The sensing membranes were deposited over this contact and acted as indicating electrodes. Under optimum conditions, the SMX sensor displayed slopes of about −58.7 mV/decade in a range from 12.7 to 250 μg/mL, providing a detection limit of 3.85 μg/mL and a sampling throughput of 36 samples/h with a reagent consumption of 3.3 mL per sample. The system was adjusted later to multiple analyte detection by including a second potentiometric cell on the LTCC/μPOT device. No additional reference electrode was required. This concept was applied to Trimethoprim (TMP), always administered concomitantly with sulphonamide drugs, and tested in fish-farming waters. The biparametric microanalyzer displayed Nernstian behaviour, with average slopes −54.7 (SMX) and +57.8 (TMP) mV/decade. To demonstrate the microanalyzer capabilities for real applications, it was successfully applied to single and simultaneous determination of SMX and TMP in aquaculture waters.