Näkökulmia nykykulttuurin tutkimukseen

Kirjallisuusarvostelu

Kansan huvituksista kahden puolen ramppia

Kirja-arvio

Hannu ja Henna

Julkaisussa virheellisesti säestäjänä Helsingin Polyphon-orkesteri, joht. Erkki Linko.

Maj Lind 1973 : Alkuerä [Raekallio, Luolajan-Mikkola]

Soitinnus: piano.

Yrittäjyys suomalaisessa yhteiskunnassa

Tässä kandidaatintyössä käsitellään yrittäjyyttä suomalaisessa yhteiskunnassa erityisesti yrityksen perustamisen näkökulmasta. Työn tavoitteena on tutkia yrittäjän ominaisuuksia ja yhteiskunnan tarjoamia mahdollisuuksia yrittäjyyteen sekä yrityksen perustamiseen. Lisäksi työssä käsitellään yrittäjyyteen liittyviä haasteita ja mahdollisuuksia sekä yrittäjyyttä tulevaisuudessa. Tutkimus tehdään ajankohtaisten kirjallisuuslähteiden pohjalta. Yrityksen perustamiseen liittyy paljon byrokratiaa ja henkilökohtaisia riskejä, mikä vaikuttaa yrittäjyyteen liittyviin asenteisiin. Yhteiskunta tarjoaa uusille ja olemassa oleville yrittäjille reilusti tukia, mutta ongelmana on tukijärjestelmän pirstaleisuus. Haasteita luovat myös yrittäjän sisäiset tekijät ja yhteiskunnassa tapahtuvat jatkuvat muutokset. Merkittävämpänä haasteena ja yrittäjyyden esteenä Suomessa voidaan nähdä yrittäjyyteen vaadittavien henkilökohtaisten ominaisuuksien ja motivaation puute yksilötasolla. Yhteiskunnassa vallitsevat trendit vaikuttavat yrittäjyyteen. Tulevaisuudessa yritysten määrän voidaan odottaa kasvavan työrakenteen murroksen myötä, ja väestön ikääntyminen aiheuttaa erityisesti nuorten yrittäjien määrän kasvua. Digitalisoituminen puolestaan luo jatkuvasti uusia liiketoimintamahdollisuuksia, joita yrittäjät voivat hyödyntää.

Henna for brides and gazelles : ritual, women's work, and tourism in Morocco

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Henna for brides and gazelles : ritual, women's work, and tourism in Morocco

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Rede de atenção à saúde mental de base comunitária: a experiência de Santo André

Os distúrbios psiquiátricos constituem um grave problema de saúde pública. Por muitos anos, a única terapêutica disponível ao portador de transtornos mentais era a internação em hospitais psiquiátricos. Hoje a Organização Mundial de Saúde recomenda os serviços de base comunitária como modelo de tratamento em saúde mental. Assim, o objetivo é descrever as características de uma rede de atenção à saúde mental de base comunitária no município de Santo André, SP. Foi realizado um estudo retrospectivo do tipo descritivo, em dados secundários do período de 1987 a 2006. O estudo incidiu sobre o histórico, a infra-estrutura, os recursos humanos, a produção, as práticas e processos de trabalho dos serviços de saúde mental de Santo André. Foram analisados documentos do Programa Municipal de Saúde Mental, da Secretaria Municipal de Saúde, da Prefeitura de Santo André, da Associação José Martins de Araújo Júnior-Organização Social De Volta Para Casa. A Secretaria Municipal de Saúde proveu meios para uma transformação dos serviços de saúde mental no período estudado, partindo de um atendimento exclusivamente manicomial para uma rede de serviços de saúde mental com modelo centrado na comunidade, focando a doença no aspecto psicossocial e com abordagem por equipe multiprofissional. Estas ações no município de Santo André foram corroborativas aos esforços da sociedade civil e o pleno desenvolvimento da mudança do modelo hospitalocêntrico

Neural activity changes to emotional stimuli in healthy individuals under chronic use of clomipramine

Previous functional magnetic resonance imaging (fMRI) studies examined neural activity responses to emotive stimuli in healthy individuals after acute/subacute administration of antidepressants. We now report the effects of repeated use of the antidepressant clomipramine on fMRI data acquired during presentation of emotion-provoking and neutral stimuli on healthy volunteers. A total of 12 volunteers were evaluated with fMRI after receiving low doses of clomipramine for 4 weeks and again after 4 weeks of washout. Fear-, happiness-, anger-provoking and neutral pictures from the International Affective Picture System (IAPS) were used. Data analysis was performed with statistical parametric mapping (P < 0.05). Paired t-test comparisons for each condition between medicated and unmedicated states showed, to negative valence paradigms, decrease in brain activity in the amygdala when participants were medicated. We also demonstrated, across both positive and negative valence paradigms, consistent decreases in brain activity in the medicated state in the anterior cingulate gyrus and insula. This is the first report of modulatory effects of repeated antidepressant use on the central representation of somatic states in response to emotions of both negative and positive valences in healthy individuals. Also, our results corroborate findings of antidepressant-induced temporolimbic activity changes to emotion-provoking stimuli obtained in studies of subjects treated acutely with such agents.

Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendages.

Organs developing as appendages of the ectoderm are initiated from epithelial thickenings called placodes. Their formation is regulated by interactions between the ectoderm and underlying mesenchyme, and several signalling molecules have been implicated as activators or inhibitors of placode formation. Ectodysplasin (Eda) is a unique signalling molecule in the tumour necrosis factor family that, together with its receptor Edar, is necessary for normal development of ectodermal organs both in humans and mice. We have shown previously that overexpression of the Eda-A1 isoform in transgenic mice stimulates the formation of several ectodermal organs. In the present study, we have analysed the formation and morphology of placodes using in vivo and in vitro models in which both the timing and amount of Eda-A1 applied could be varied. The hair and tooth placodes of K14-Eda-A1 transgenic embryos were enlarged, and extra placodes developed from the dental lamina and mammary line. Exposure of embryonic skin to Eda-A1 recombinant protein in vitro stimulated the growth and fusion of placodes. However, it did not accelerate the initiation of the first wave of hair follicles giving rise to the guard hairs. Hence, the function of Eda-A1 appears to be downstream of the primary inductive signal required for placode initiation during skin patterning. Analysis of BrdU incorporation indicated that the formation of the epithelial thickening in early placodes does not involve increased cell proliferation and also that the positive effect of Eda-A1 on placode expansion is not a result of increased cell proliferation. Taken together, our results suggest that Eda-A1 signalling promotes placodal cell fate during early development of ectodermal organs.

Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB.

Ductal growth of the mammary gland occurs in two distinct stages. The first round of branching morphogenesis occurs during embryogenesis, and the second round commences at the onset of puberty. Currently, relatively little is known about the genetic networks that control the initial phases of ductal expansion, which, unlike pubertal development, proceeds independent of hormonal input in female mice. Here we identify NF-κB downstream of the TNF-like ligand ectodysplasin (Eda) as a unique regulator of embryonic and prepubertal ductal morphogenesis. Loss of Eda, or inhibition of NF-κB, led to smaller ductal trees with fewer branches. On the other hand, overexpression of Eda caused a dramatic NF-κB-dependent phenotype in both female and male mice characterized by precocious and highly increased ductal growth and branching that correlated with enhanced cell proliferation. We have identified several putative transcriptional target genes of Eda/NF-κB, including PTHrP, Wnt10a, and Wnt10b, as well as Egf family ligands amphiregulin and epigen. We developed a mammary bud culture system that allowed us to manipulate mammary development ex vivo and found that recombinant PTHrP, Wnt3A, and Egf family ligands stimulate embryonic branching morphogenesis, suggesting that these pathways may cooperatively mediate the effects of Eda.