Caterina Llull i Çabastida: una mercantessa catalana nella Sicilia del '400

El trabajo se asienta sobre en el estudio y la edición de un libro de contabilidad del siglo XV Libre de la magnifica señora Caterina Llull començat el 2 de jener de 1472 compilado por una mujer catalana Caterina Llull y Çabastida que vivió entre Siracusa y Barcelona y que se conserva en el Archivo del Centro Borja de S. Cugat del Vallès dentro del fondo archivístico privado de la familia Requesens. La investigación de la fuente mencionada se ha completado con otros documentos del mismo archivo familiar y con la documentación de otros archivos catalanes permitiendome, además, profundizar en algunos aspectos económicos y sociales de la Sicilia oriental del siglo XV, y llevar a cabo un análisis más amplio de las características y de los diferentes aspectos del así llamado "Medioevo en femenino". La tesis està dividida en tres partes: estudio paleografico-codocologico, socio-economico y transcripciòn completa del manuscrito con indice onomàstico.

A general history and collection of voyages and travels, arranged in systematic order: forming a complete history of the origin and progress of navigation, discovery, and commerce, by sea and land, from the earliest ages to the present time.

"Catalogue of voyages and travels": v. 18, p. [529]-628.

Yorkshire, past and present: a history and a description of the three ridings of the great county of York, from the earliest ages to the year 1870; with an account of its manufactures, commerce, and civil and mechanical engineering.

Mode of access: Internet.

An historical and descriptive account of China; its ancient and modern history, language, literature, religion, government, industry, manners, and social state; intercourse with Europe from the earliest ages; missions and embassies to the imperial court; British and foreign commerce; directions to navigators; state of mathematics and astronomy; survey of its geography, geology, botany, and zoology.

Added t.p., illustrated.

Le moyen âge et la renaissance, histoire et description des mœurs et usages, du commerce et de l'industrie, des sciences, des arts, des littératures et des beaux-arts en Europe.

Mode of access: Internet.

Evaluation of superficial microhardness in dental enamel with different eruptive ages

This study evaluated the superficial microhardness of enamel in teeth at different posteruptive ages (before eruption in the oral cavity, 2-3 years after eruption, 4-10 years after eruption and more than 10 years after eruption). The study sample was composed of 134 specimens of human enamel. One fragment of each tooth was obtained from the flattest central portion of the crown to produce specimens with 3 x 3 mm. The enamel blocks were minimally flattened out and polished in order to obtain a flat surface parallel to the base, which is fundamental for microhardness testing. Microhardness was measured with a microhardness tester and a Knoop diamond indenter, under a static load of 25 g applied for 5 seconds. Comparison between the superficial microhardness obtained for the different groups was performed by analysis of Student's t test. The results demonstrated that superficial microhardness values have a tendency to increase over the years, with statistically significant difference only between unerupted enamel and that with more than 10 years after eruption. According to the present conditions and methodology, it was concluded that there were differences between the superficial micro-hardness of specimens at different eruptive ages, revealing an increasing mineralization. However, this difference was significant only between unerupted specimens and those with more than 10 years after eruption.

A PCR-based method of screening individuals of all ages, from neonates to the elderly, for familial hyperaldosteronism type I

Aim: Unless specifically treated (glucocorticoids in low doses), Familial Hyperaldosteronism Type I(FH-I) may result in early death from stroke. We report the successful application of a rapid, polymerase chain reaction (PCR)-based method of detecting the 'hybrid' 11 beta-hydroxylase (11 beta-OHase)/aldosterone synthase (AS) gene as a screening test for FH-I. Methods: 'Long-PCR' was used to amplify, concurrently, a 4 kb fragment of AS gene (both primers AS-specific) and a 4 kb fragment of the hybrid gene (5' primer 11 beta-OHase-specific, 3'primer AS-specific) from DNA extracted from blood either collected locally or transported from elsewhere. Sample collection and transport were straightforward. This 4 kb fragment contains all the currently recognised hybrid gene 'crossover' points. Results: Within a single family, long-PCR identified all 21 individuals known to have FH-I. Hypertension was corrected in all 11 treated with glucocorticoids. Nine with normal blood pressure are being closely followed for development of hypertension. Long-PCR cord blood analysis excluded FH-I in three neonates born to affected individuals. Long-PCR newly identified two other affected families: (1) a female (60 years) with a personal and family history of stroke and her normotensive daughter (40 years), and (2) a female (51 years) previously treated for primary aldosteronism with amiloride, her two hypertensive sons (14 and 16 years) and her hypertensive mother (78 years). No false negative or false positive results have yet been encountered. At least seven other centres have successfully performed this test. Conclusion: Long-PCR is a reliable method of screening individuals of all ages for FH-I.

Paternal and maternal ages at conception and risk of bipolar affective disorder in their offspring

Background. A consistent association between paternal age and their offspring`s risk of schizophrenia has been observed, with no independent association with maternal age. The relationship of paternal and maternal ages with risk of bipolar affective disorders (BPAD) in the offspring is less clear. The present study aimed at testing the hypothesis that paternal age is associated with their offspring`s risk of BPAD, whereas maternal age is not. Method. This population-based cohort study was conducted with individuals born in Sweden during 1973-1980 and still resident there at age 16 years. Outcome was first hospital admission with a diagnosis of BPAD. Hazard ratios (HRs) were calculated using Cox`s proportional hazard regression. Results. After adjustment for all potential confounding variables except maternal age, the HR for risk of BPAD for each 10-year increase in paternal age was 1.28 [95% confidence interval (Cl) 1.11-1.48], but this fell to 1.20 (95% CI 0.97-1.48) after adjusting for maternal age. A similar result was found for maternal age and risk of BPAD [HR 1.30 (95% CI 1.08-1.56) before adjustment for paternal age, HR 1.12 (95% Cl 0.86-1.45) after adjustment]. The HR associated with having either parent aged 30 years or over was 1.26 (95% CI 1.01-1.57) and it was 1.45 (95%, CI 1.16-1.81) if both parents were >30 years. Conclusions. Unlike schizophrenia, the risk of BPAD seems to be associated with both paternal and maternal ages.