Construir una alternativa comercial de venta bajo catálogo para ropa interior

El presente trabajo está encaminado a crear una alternativa comercial de venta bajo catálogo de ropa interior; para el que se definirán parámetros que serán útiles en su implantación, los mismos que permitirán que los productos comercializados bajo esta modalidad, sean percibidos por los clientes de manera diferente y favorable. Previo definir dichos parámetros, se realizo un análisis de las necesidades del mercado, para determinar cuales podrían ser los productos que se comercializarían, enfocados a un grupo de compradores específicos y que además se diferencien de los competidores inmediatos, asegurando con ello una ventaja competitiva defendible. Para establecer cuales serían las estrategias que podrían ser utilizadas en la penetración del mercado, se determino cuales son los competidores mas próximos, se analizo sus puntos fuertes y débiles, además se infirieron en las estrategias de mercado utilizadas por estas empresas; basados en esto y previo un análisis PODA de La Comercializadora, se formulo once estrategias que proporcionaran en su momento una guía en el accionar en situaciones diferentes. En cuanto al estudio económico y financiero arroga los siguientes datos en variables como el VAN 87 .931.62, TIR 57.62 % considerando una tasa de descuento del 18%, lo que indica su factibilidad para su posterior ejecución. Al considerar las características que presenta la venta directa se deberán tomar en cuenta ciertos aspectos para la implantación adecuada, en este canal de distribución.

L'Église de Brou, poème, par M. G. de Moyria,... précédé d'une introduction par M. Edgar Quinet, suivi de stances sur le même sujet par MM. L. Bruys et X. Marmier

Comprend : Notre-Dame de Brou ; Stances ; Introduction

Les hormones sexuelles. 2, Ovulation, menstruation, gestation / par E. Allen, G. Hartman, S. Zuckerman... [et al.]

Collection : Actualités scientifiques et industrielles ; 602, 6

Edgar County soils /

Cover title.

Edgar, oder Blätter aus dem leben eines dichters.

Mode of access: Internet.

The complete works of Edgar Allan Poe,/

At head of title: The Monticello edition.

Edgar Allan Poe. Ein beitrag zur kenntnis und würdigung des dichters

Includes bibliographical references.

The works of Edgar Allan Poe /

"Amontillado edition."

Granulocyte Colony-stimulating Factor (g-csf) Positive Effects On Muscle Fiber Degeneration And Gait Recovery After Nerve Lesion In Mdx Mice.

G-CSF has been shown to decrease inflammatory processes and to act positively on the process of peripheral nerve regeneration during the course of muscular dystrophy. The aims of this study were to investigate the effects of treatment of G-CSF during sciatic nerve regeneration and histological analysis in the soleus muscle in MDX mice. Six-week-old male MDX mice underwent left sciatic nerve crush and were G-CSF treated at 7 days prior to and 21 days after crush. Ten and twenty-one days after surgery, the mice were euthanized, and the sciatic nerves were processed for immunohistochemistry (anti-p75(NTR) and anti-neurofilament) and transmission electron microscopy. The soleus muscles were dissected out and processed for H&E staining and subsequent morphologic analysis. Motor function analyses were performed at 7 days prior to and 21 days after sciatic crush using the CatWalk system and the sciatic nerve index. Both groups treated with G-CSF showed increased p75(NTR) and neurofilament expression after sciatic crush. G-CSF treatment decreased the number of degenerated and regenerated muscle fibers, thereby increasing the number of normal muscle fibers. The reduction in p75(NTR) and neurofilament indicates a decreased regenerative capacity in MDX mice following a lesion to a peripheral nerve. The reduction in motor function in the crushed group compared with the control groups may reflect the cycles of muscle degeneration/regeneration that occur postnatally. Thus, G-CSF treatment increases motor function in MDX mice. Nevertheless, the decrease in baseline motor function in these mice is not reversed completely by G-CSF.

Activation Of The Low Molecular Weight Protein Tyrosine Phosphatase In Keratinocytes Exposed To Hyperosmotic Stress.

Herein, we provide new contribution to the mechanisms involved in keratinocytes response to hyperosmotic shock showing, for the first time, the participation of Low Molecular Weight Protein Tyrosine Phosphatase (LMWPTP) activity in this event. We reported that sorbitol-induced osmotic stress mediates alterations in the phosphorylation of pivotal cytoskeletal proteins, particularly Src and cofilin. Furthermore, an increase in the expression of the phosphorylated form of LMWPTP, which was followed by an augment in its catalytic activity, was observed. Of particular importance, these responses occurred in an intracellular milieu characterized by elevated levels of reduced glutathione (GSH) and increased expression of the antioxidant enzymes glutathione peroxidase and glutathione reductase. Altogether, our results suggest that hyperosmostic stress provides a favorable cellular environment to the activation of LMWPTP, which is associated with increased expression of antioxidant enzymes, high levels of GSH and inhibition of Src kinase. Finally, the real contribution of LMWPTP in the hyperosmotic stress response of keratinocytes was demonstrated through analysis of the effects of ACP1 gene knockdown in stressed and non-stressed cells. LMWPTP knockdown attenuates the effects of sorbitol induced-stress in HaCaT cells, mainly in the status of Src kinase, Rac and STAT5 phosphorylation and activity. These results describe for the first time the participation of LMWPTP in the dynamics of cytoskeleton rearrangement during exposure of human keratinocytes to hyperosmotic shock, which may contribute to cell death.