Letter to Robert Nelles from John McLelland

Letter to Robert Nelles from John McLelland saying that he is sending 3 pounds and to please let him know when the next payment is due, May 29, 1850.

Bioavailability study of oral and intravenous OGT 719, a novel nucleoside analogue with preferential activity in the liver

Purpose: Although oral fluoropyrimidine pro-drugs are increasingly being administered in preference to intravenous nucleoside analogues in cancer chemotherapy, their activation in malignant liver tissue may be insufficient. OGT 719 (1-galactopyranosyl-5-fluorouracil) is a novel nucleoside analogue, preferentially localized in hepatocytes and hepatoma cells via the asialoglycoprotein receptor. The aim of this study was to assess the systemic bioavailability of this rationally designed drug in 16 patients with advanced solid cancers. Method: Crossover pharmacokinetic study of oral (400 or 800 mg) and intravenous (250 mg/m 2) OGT 719. Results: Linear pharmacokinetics and oral bioavailability of approximately 25% were observed at the dose levels used in this study. Like other 5-FU prodrugs, considerable interpatient variability was observed in bioavailability following oral dosing. The mean half-life for oral doses was 4 h. OGT 719 was well tolerated. No objective tumour responses were demonstrated. Conclusion: The systemic bioavailability and half-life of oral OGT 719 are sufficient to merit dose escalation studies with frequent daily dosing. Subsequent efficacy studies should be performed in patients with primary and secondary liver malignancies.

Bioavailability study of oral and intravenous OGT 719, a novel nucleoside analogue with preferential activity in the liver

Purpose: Although oral fluoropyrimidine pro-drugs are increasingly being administered in preference to intravenous nucleoside analogues in cancer chemotherapy, their activation in malignant liver tissue may be insufficient. OGT 719 (1-galactopyranosyl-5-fluorouracil) is a novel nucleoside analogue, preferentially localized in hepatocytes and hepatoma cells via the asialoglycoprotein receptor. The aim of this study was to assess the systemic bioavailability of this rationally designed drug in 16 patients with advanced solid cancers. Method: Crossover pharmacokinetic study of oral (400 or 800 mg) and intravenous (250 mg/m 2) OGT 719. Results: Linear pharmacokinetics and oral bioavailability of approximately 25% were observed at the dose levels used in this study. Like other 5-FU prodrugs, considerable interpatient variability was observed in bioavailability following oral dosing. The mean half-life for oral doses was 4 h. OGT 719 was well tolerated. No objective tumour responses were demonstrated. Conclusion: The systemic bioavailability and half-life of oral OGT 719 are sufficient to merit dose escalation studies with frequent daily dosing. Subsequent efficacy studies should be performed in patients with primary and secondary liver malignancies.

Conjunctivitis associated with Chlamydia pecorum in three koalas (Phascolarctos cinereus) in the Mount Lofty Ranges, South Australia

Chlamydiosis is a significant factor contributing to the decline of koala (Phascolarctos cinereus) populations in Australia but has not previously been reported in South Australia. We describe conjunctivitis in three wild koalas from South Australia, with Chlamydia pecorum identified by quantitative PCR.

Stilus – calamus – griffel – stift. Zur metonymischen Metaphorik des Stilbegriffs in der mittellateinischen und mittelhochdeutschen Literatur

„Die Übertragung der Bezeichnung für den Schreibgriffel auf die Verfasstheit geschriebener Texte“ scheint bis zum Ende der Antike, ja bis ins 14. Jahrhundert „noch als Metapher erfahren worden zu sein“ (H.-U. Gumbrecht zur Geschichte des Stilbegriffs in ders./K. Ludwig Pfeiffer (Hg.), Stil. Geschichte und Funktionen eines kulturwissenschaftlichen Diskurselements, Frankfurt/M. 1986 [stw 633], S. 735 und 741). Der angebotene Beitrag verifiziert diese These am Beispiel aussagekräftiger Textstellen der mittellateinischen und der mittelhochdeutschen Literatur, in denen Schreibgeräte (wie stilus, calamus, griffel, stift) im Kontext inszenierter Schreib- und Lebens-‚Stile’ stehen. Als Werkzeug des Schreibens ist der stilus eine Verlängerung der Hand, des Körpers, aber auch des Habitus, der Lebensart seines Besitzers oder seiner Besitzerin. Die herangezogenen Textbeispiele stammen aus Alanus’ ab Insulis ›Anticlaudianus‹ (Anrufung des Phoebus), aus Konrad Flecks ›Flore und Blanscheflur‹ (der Griffel als Minnebote) sowie aus Heinrichs von Mügeln Spruchdichtung und Johannes’ von Tepl ›Ackermann‹ (stift und stipulus als Operatoren dichterischer Gestaltung).

Epicures delight /

Mode of access: Internet.

School of Nursing Class of 2007

Top Row: Alexis Adamjee, Jennifer Ahlquist, Crista Andress, Dawn Arringdale, Freda Ayensu, Genevieve Balangero, Maureen Berlucchi, Amanda Bevier, Nina Bibicoff, Rachel Black, Denise Black, Jackie Braun, Kristen Bryant, Betty Burgner, Julie Butchart, Nicholas Cameron, Jessica Carver, Christine Cha, Kelly Clement

Row 2: Lauren Cochran, Kathleen Connell, Amanada Cooperwasser, Lindsay Cousino, Lindsey Evans, Stephen Kilijanczyk, Kathryn Evans, Kathryn Bucrek, Ida Elise Broadwater, Renee Havey, Sharon Warner, Katie Darnell, Katrina DeWitt, Kolleen Kowalske, Keather Rechtweg, Kristen Cowan, Alison Damioli, Dinah Denton, Melinda Dobie

Row 3: Rosemarie Donnelly, Kelly Doyle, Deanna Dusseau, Jacqueline Elegant, Ashley Faulk, Kristin Ferszt, Christine Catalan, Sarah Borgstadt-Smith, Paul Holtz, Tracy Jakubiec, Chemari Justice, Patricia Oppenheim, Kelly Fleming, Melissa Foster, Emily French, Tracy Gallo, Kathie Garrett, Jacqueline Garry

Row 4: Monique Gennari, Megan Gerlinger, Deborah Glazer, Terah Griggs, Edward Grosser, Kristy Haigh, Amanda Halbert, Jennifer Hammer, Emily Harris, Erin Harris, Elizabeth Hassenrik, Elizabeth Heinbeck

Row 5: Brianna Hirsch, Jessica Hoffman, Heather Hoffner, Bridget Holtz, Melissa Housefield, Sarah Hudson, Kathy Huffnagle, Hilary Hunt, Ashley Jannesen, Lauren Jarvis, Sarah Jarvis, Younhee Jee

Row 6: Ruth Jensen, Janet Wilson Johnston, Brandi Josephs, Amy Kangwankij, Julie Kramb, Dianna Krankurs, Allan Kucab, Kimberly Lai, Sarah Layher, Erin Layher, Dung Le, Hedy Leiter

Row 7: Lauren Loftus, Michael Long, Caroline Loukotka, Shoshana Love, Norma Martinez, Kristen McElreath, Lindsi McErlean, Renee McGlone, Lynne McIntosh, Ian McLelland, Ashley Mester, Anika Meyers

Row 8: Elizabeth Miles, Sarah Miller, Juliana Moore, Nicole Nastanski, Sarah Neighbours, Emily Newman, Judith Lynch-Sauer, Patricia Coleman-Burns, Judith Wismont, Kathleen Potempa, Carol Loveland-Cherry, Carolyn Sampselle, Joanne Pohl, Katie Pace, Bethany Panyard, sejal Patel, Chelsea Patnoude, Amy Jo Perry, Joseph Piotrowski

Row 9: Kate Pittel, Natalie Podolsky, Jessica Pollman, Nicole Pratt, Laura Ready, Amanda Retzbach, Katie Richards, Nicole Rico, April Robertson, Meighan Robinson, Stephanie Robinson, Talia Roesner, Autumn Romanowski, Anne Sage, Sally Scharg, Melissa Schultz, Renee Shelton, Natalie Sherry

Row 10: Rebecca Siereveld, Karen Simon, Emily Sosnowski, Elissa Stier, Darcy Stoll, Nicole Sukich, Erin Sykes-Miller, Tami Szuba, John Tallman, Michelle Taylor, Ashley Thelen, Gina Thomas, Rachel Tovian, Yuanyuan Wan, Nicole Young

Posthumous papers, bequeathed to the honourable the East India company,.

Mode of access: Internet.