1916 University of Michigan Freshman Football team

[scanned from photo album loaned to library]

University of Michigan Football Team, 1913

[scanned from photo album loaned to library]

Catalytic components of proteasomes and the regulation of proteinase activity

The proteasome (multicatalytic proteinase complex) is a large multimeric complex which is found in the nucleus and cytoplasm of eukaryotic cells. It plays a major role in both ubiquitin-dependent and ubiquitin-independent nonlysosomal pathways of protein degradation. Proteasome subunits are encoded by members of the same gene family and can be divided into two groups based on their similarity to the c~ and /3 subunits of the simpler proteasome isolated from Thermoplasma acidophilum. Proteasomes have a cylindrical structure composed of four rings of seven subunits. The 26S form of the proteasome, which is responsible for ubiquitin-dependent proteolysis, contains additional regulatory complexes. Eukaryotic proteasomes have multiple catalytic activities which are catalysed at distinct sites. Since proteasomes are unrelated to other known proteases, there are no clues as to which are the catalytic components from sequence alignments. It has been assumed from studies with yeast mutants that /3-type subunits play a catalytic role. Using a radiolabelled peptidyl chloromethane inhibitor of rat liver proteasomes we have directly identified RC7 as a catalytic component. Interestingly, mutants in Prel, the yeast homologue of RC7, have already been reported to have defective chymotrypsin-like activity. These results taken together confirm a direct catalytic role for these/3-type subunits. Proteasome activities are sensitive to conformational changes and there are several ways in which proteasome function may be modulated in vivo. Our recent studies have shown that in animal cells at least two proteasome subunits can undergo phosphorylation, the level of which is likely to be important for determining proteasome localization, activity or ability to form larger complexes. In addition, we have isolated two isoforms of the 26S proteinase.

Neuromarketing: qu�� sabe de ti, que los dem��s no

En este documento se describe la forma en la que el neuromarketing hace que la segmentaci��n de g��nero, sea una herramienta funcional para poder conocer al cliente y sus deseos. Se explorar�� el mercadeo desde sus inicios, mostrando c��mo evoluciona hasta enfocarse en el cliente como su principal objetivo. Al llegar a este punto el mercadeo se encuentra con un nuevo aliado, la neurociencia, la cual le muestra que por medio de diversas t��cnicas tiene la capacidad de medir las reacciones de su consumidor, a los distintos est��mulos que le env��a para cautivarlo. En este proceso se dan a conocer las tecnolog��as m��s usadas por el neuromarketing para este fin; adem��s se expondr�� parte de la anatom��a del consumidor con la que interact��a el mercadeo: sus sentidos y su cerebro. Posteriormente se explica c��mo a trav��s del entendimiento de las percepciones y comportamiento del cliente, puede beneficiarse el mercadeo en sus prop��sitos y su vez, satisfacer al mercado en lo que realmente quiere.