Catalogs of Michigan-based motor truck companies.

Mode of access: Internet.

Transport coefficients of air to 8000° K /

"29 September 1958."

Corporation José R. Lindley: Balanced Scorecard Implementation.

La Corporación José R. Lindley es una de las organizaciones más importantes que operan en el país, con una prestigiosa trayectoria en el mercado de gaseosas a través de su marca líder Inca Kola. Esta empresa se ha caracterizado por mantenerse a la vanguardia del sector, el cual en los últimos años se ha mostrado altamente competitivo. Con la fi nalidad de mantener su liderazgo, hacer frente con éxito al difícil entorno del mercado local e incursionar en nuevos mercados internacionales, la Corporación José R. Lindley se ha preocupado constantemente por incorporar fi losofías y herramientas de gestión que le permitan asegurar su sostenibilidad en el tiempo, con una visión de futuro. En este sentido, decidió implementar un Balanced Scorecard (BSC), como una herramienta para medir y mejorar su productividad y efi ciencia, en el marco de su estrategia corporativa. En otras palabras, el BSC le facilitó monitorear el grado de acierto en la puesta en marcha de su estrategia. En este contexto, el caso ilustra cómo se realizó el proceso de implementación de un BSC en la Corporación José R. Lindley, mostrando la complejidad del proceso que involucró recursos fi nancieros y una dedicación importante de la organización, en especial provenientes de la Alta Dirección y del área de Sistemas de Información para el Soporte Tecnológico. Asimismo, el caso muestra cómo es posible traducir una estrategia en un grupo de objetivos y medidas concretas, a través del BSC. En función a la relación causa-efecto, vincula los objetivos, con sus respectivos indicadores, iniciativas estratégicas y planes de acción correspondientes.

Corporation laws of Virginia (being an Act concerning corporations, which became a law May 21, 1903; with amendments contained in acts 1904, 1906, and 1908; and other general acts relating to corporations) together with abstracts of the decisions of the courts, and a full collection of forms,

Mode of access: Internet.

Insetos em presépios e as "formigas vestidas" de Jules Martin (1832-1906): uma curiosa manufatura paulistana do final do século XIX

Encontrados no Brasil desde os primórdios da colonização portuguesa, os presépios logo tiveram de adaptar-se à realidade local, circunstância muito propícia ao aparecimento de concepções heterodoxas e ao emprego de elementos exóticos da fauna e flora de cada região. Como registros envolvendo insetos são muito pouco comuns, chama a atenção que fêmeas de saúva, Atta sp. (Hymenoptera, Formicidae), tenham sido aproveitadas na composição de presépios no estado de São Paulo. Tendo subsistido pelo menos até a década 1960, os "presépios de formigas" existentes em cidades como Embu das Artes poderiam estar relacionados às "formigas vestidas" criadas por Jules Martin, curiosa manufatura paulistana do último quartel do século XIX.

Changes in Glucose and Glutamine Lymphocyte Metabolisms Induced by Type I Interferon alpha

In lymphocytes (LY), the well-documented antiproliferative effects of IFN-alpha are associated with inhibition of protein synthesis, decreased amino acid incorporation, and cell cycle arrest. However, the effects of this cytokine on the metabolism of glucose and glutamine in these cells have not been well investigated. Thus, mesenteric and spleen LY of male Wistar rats were cultured in the presence or absence of IFN-alpha, and the changes on glucose and glutamine metabolisms were investigated. The reduced proliferation of mesenteric LY was accompanied by a reduction in glucose total consumption (35%), aerobic glucose metabolism (55%), maximal activity of glucose-6-phosphate dehydrogenase (49%), citrate synthase activity (34%), total glutamine consumption (30%), aerobic glutamine consumption (20.3%) and glutaminase activity (56%). In LY isolated from spleen, IFN alpha also reduced the proliferation and impaired metabolism. These data demonstrate that in LY, the antiproliferative effects of IFN alpha are associated with a reduction in glucose and glutamine metabolisms.

Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase

Structures of free, substrate-bound and product-bound forms of Escherichia coli xanthine-guanine phosphoribosyltransferase (XGPRT) have been determined by X-ray crystallography. These are compared with the previously determined structure of magnesium and sulphate-bound XPRT. The structure of free XGPRT at 2.25 Angstrom resolution confirms the flexibility of residues in and around a mobile loop identified in other PRTases and shows that the cis-peptide conformation of Arg37 at the active site is maintained in the absence of bound ligands. The structures of XGPRT complexed with the purine base substrates guanine or xanthine in combination with cPRib-PP, an analog of the second substrate PRib-PP, have been solved to 2.0 Angstrom resolution. In these two structures the disordered phosphate-binding loop of uncomplexed XGPRT becomes ordered through interactions with the 5'-phosphate group of cPRib-PP. The cyclopentane ring of cPRib-PP has the C3 exo pucker conformation, stabilised by the cPRib-PP-bound Mg2+. The purine base specificity of XGPRT appears to be due to water-mediated interactions between the 2-exocyclic groups of guanine or xanthine and side-chains of Glu136 and Asp140, as well as the main-chain oxygen atom of Ile135. Asp92, together with Lys115, could help stabilise the N7-protonated tautomer of the incoming base and could act as a general base to remove the proton from N7 .when the nucleotide product is formed. The 2.6 Angstrom resolution structure of XGPRT complexed with product GMP is similar to the substrate-bound complexes. However, the ribose ring of GMP is rotated by similar to 24 degrees compared with the equivalent ring in cPRib-PP. This rotation results in the loss of all interactions between the ribosyl group and the enzyme in the product complex. (C) 1998 Academic Press.