Altered brain mechanisms of emotion processing in pre-manifest Huntington's disease.

Huntington's disease is an inherited neurodegenerative disease that causes motor, cognitive and psychiatric impairment, including an early decline in ability to recognize emotional states in others. The pathophysiology underlying the earliest manifestations of the disease is not fully understood; the objective of our study was to clarify this. We used functional magnetic resonance imaging to investigate changes in brain mechanisms of emotion recognition in pre-manifest carriers of the abnormal Huntington's disease gene (subjects with pre-manifest Huntington's disease): 16 subjects with pre-manifest Huntington's disease and 14 control subjects underwent 1.5 tesla magnetic resonance scanning while viewing pictures of facial expressions from the Ekman and Friesen series. Disgust, anger and happiness were chosen as emotions of interest. Disgust is the emotion in which recognition deficits have most commonly been detected in Huntington's disease; anger is the emotion in which impaired recognition was detected in the largest behavioural study of emotion recognition in pre-manifest Huntington's disease to date; and happiness is a positive emotion to contrast with disgust and anger. Ekman facial expressions were also used to quantify emotion recognition accuracy outside the scanner and structural magnetic resonance imaging with voxel-based morphometry was used to assess the relationship between emotion recognition accuracy and regional grey matter volume. Emotion processing in pre-manifest Huntington's disease was associated with reduced neural activity for all three emotions in partially separable functional networks. Furthermore, the Huntington's disease-associated modulation of disgust and happiness processing was negatively correlated with genetic markers of pre-manifest disease progression in distributed, largely extrastriatal networks. The modulated disgust network included insulae, cingulate cortices, pre- and postcentral gyri, precunei, cunei, bilateral putamena, right pallidum, right thalamus, cerebellum, middle frontal, middle occipital, right superior and left inferior temporal gyri, and left superior parietal lobule. The modulated happiness network included postcentral gyri, left caudate, right cingulate cortex, right superior and inferior parietal lobules, and right superior frontal, middle temporal, middle occipital and precentral gyri. These effects were not driven merely by striatal dysfunction. We did not find equivalent associations between brain structure and emotion recognition, and the pre-manifest Huntington's disease cohort did not have a behavioural deficit in out-of-scanner emotion recognition relative to controls. In addition, we found increased neural activity in the pre-manifest subjects in response to all three emotions in frontal regions, predominantly in the middle frontal gyri. Overall, these findings suggest that pathophysiological effects of Huntington's disease may precede the development of overt clinical symptoms and detectable cerebral atrophy.

Manifest de Vallbona: una proposta d’ús de l’aigua per al segle XXI. Convertir un projecte hidràulic (canal Segarra-Garrigues) en un projecte territorial

Pocs saben que el canal Segarra-Garrigues i les obres de transformació en regadiu que l’acompanyen representen avui dia la segona inversió pública més important de Catalunya. Malgrat l’enorme inversió que s’està fent, aquesta obra, que ha d’abastar unes 70.000 ha a les comarques de Lleida, ha estat concebuda a imatge de les grans obres hidràuliques del segle xix i xx, i planteja molts dubtes sobre la incidència econòmica real que tindrà. Des del mateix territori, l’anomenat Manifest de Vallbona posa sobre la taula des del 2004 un nou tipus de canal que respongui a les necessitats reals de desenvolupament del territori i a les sensibilitats de la nova cultura de l’aigua.

« Interruption du sommeil cabalistique, ou Le devoilement des tableaux de l'antiquité. — La Crisologie chimique, divisée en deux liyres, dans laquelle est monstré et manifesté ce qui a esté caché et voilé par l'antiquité, et dans laquelle toutes difficultés de l'art sont elucidées. — Du Genre de l'or et sa genealogie, avec l'anatomie de l'eau, la genealogie et regeneration du fils du soleil ».

Commençant par : « S'il est vray que le testament soit une atestation de l'esprit et de la volonté... » et finissant par : «... partant soyez content, et louez Dieu » .

Manifest per la coeducació contra la LOCE. 'Manifiesto por la coeducación contra la LOCE'.

Resumen tomado de la revista

El manifest del col.legi Aguamansa en contra dels algoritmes tradicionals de les operacions aritmètiques (ATOA). 'El manifiesto del colegio Aguamansa en contra de los algoritmos tradicionales de las operaciones aritméticas (ATOA)'.

Monográfico con el título: 'Enterrem els algoritmes aritmètics!'. Resumen basado en el de la publicación

Latent or manifest observers : two dichotomous approaches of surveillance in mental health nursing

Background. Surveillance is a central activity among mental health nursing, but it is also questioned for its therapeutic value and considered to be custodial. Aim. The aim of this study was to describe how mental health nurses use different approaches to observe patients in relation to the practice of surveillance in psychiatric nursing care. Methods. In this study, Spradley's twelve-step ethnographic method was used. Results. Mental health nurses use their cultural knowing to observe patients in psychiatric care in various ways. Two dichotomous approaches were identified: the latent and the manifest approach. Discussion. Different strategies and techniques for observing patients are structured along two dichotomies. The underlying relationships between these two different dichotomous positions transform the act of observing into surveillance. This is further developed in a theoretical model called the powerful scheme of observation and surveillance (PSOS).

Portugal: manifest for the republic education or teacher education under scrutiny

Starting from the analysis of a Manifest placed in the World Wide Web in order to gather signatures, the paper discusses the arousal of a wide spread movement of scepticism in the so called Portuguese “civil socie ty” against the overall result of almost forty years of uninterrupted educational reform that has taken place in Portugal since the late sixties and has lead to an increasing percentage of illiteracy and innumeracy. That Manifest is presented as part of a broader movement, deeply rooted in the Portuguese society, and silent so far, which is becoming stronger and has now strength enough to be part of the political agenda. It is also our concern to unveil an emerging trend of blaming sciences of education and badly trained teachers as responsible for the poor outcome of our schooling system.

One-loop N-point superstring amplitudes with manifest d=4 supersymmetry

The hybrid formalism for the superstring is used to compute one-loop amplitudes with an arbitrary number of external d = 4 supergravity states. These one-loop N-point amplitudes are expressed as Koba-Nielsen-like formulas with manifest d = 4 supersymmetry. (C) 2002 Published by Elsevier B.V. B.V.

Manifest electromagnetic duality in closed superstring field theory

The free action for massless Ramond-Ramond fields is derived from closed superstring field theory using the techniques of Siegel and Zwiebach. For the uncompactified Type IIB superstring, this gives a manifestly Lorentz-covariant action for a self-dual five-form field strength. Upon compactification to four dimensions, the action depends on a U(1) field strength from 4D N = 2 supergravity. However, unlike the standard Maxwell action, this action is manifestly invariant under the electromagnetic duality transformation which rotates F-mn into epsilon(mnpq)F(pq).

Super-Maxwell actions with manifest duality

Superstring field theory was recently used to derive a four-dimensional Maxwell action with manifest duality. This action is related to the McClain-Wu-Yu Hamiltonian and can be locally coupled to electric and magnetic sources. In this letter, the manifestly dual Maxwell action is supersymmetrized using N = 1 and N = 2 superspace. The N = 2 version may be useful for studying Seiberg-Witten duality. © 1997 Elsevier Science B.V.

Conformal compensators and manifest type IIB S-duality

Using the conformal compensator superfields of N = 2 D = 4 supergravity, the Type IIB S-duality transformations are expressed as a linear rotation which mixes the compensator and matter superfields. The classical superspace action for D = 4 compactifications of Type IIB supergravity is manifestly invariant under this transformation. Furthermore, the introduction of conformal compensators allows a Fradkin-Tseytlin term to be added to the manifestly SL(2,Z)-covariant sigma model action of Townsend and Cederwall. © 1998 Published by Elsevier Science B.V.