38 resultados para Magi
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L'ex Palazzo Magi è opera databile attorno al 1773 ed attribuibile al progetto di due importanti architetti di Pesaro, ovvero Gian Andrea Lazzarini e il suo allievo Tommaso Bicciaglia. Quest'ultimo sembra al momento esserne il vero artefice. Commissionato da Francesco Magi sorse su quello che precedentemente era uno spazio pubblico e per questo probabilmente reca lo stemma del Comune di Saludecio nel concio di chiave del portale d'accesso. Negli anni, il Palazzo è stato soggetto a numerosi interventi che ne hanno alterato la percezione e ne hanno occultato parte delle decorazioni. Tramite il progetto, si è intervenuto concettualmente e concretamente in due maniere differenti sul Palazzo e sui due giardini. Per il Palazzo e per il giardino ad esso adiacente, si assumerà un atteggiamento di restauro e conservazione, mentre per il secondo giardino di valorizzazione entrambe volte a rendere possibile la lettura dell’opera nel suo complesso. La galleria del piano nobile, con la sua bellezza e ricchezza, assumerà insieme al giardino adiacente al prospetto secondario, un carattere di rappresentanza differente dal giardino frutteto. Tutti gli interventi di progetto saranno minimi e localizzati contribuendo a far riemergere lo splendore che ha reso il Palazzo degno di esser tutelato. L’intento progettuale è stato quello di inserire i tre nuovi volumi all’interno di un progetto unitario rispettoso della valenza storica dell’edificio preesistente. Per questo si è cercato di stabilire un dialogo tra i nuovi volumi tramite l’utilizzo dei medesimi materiali e del medesimo linguaggio architettonico. Inoltre le nuove costruzioni non alterano in alcun modo l’identità del palazzo cercando piuttosto di diventarne parte integrante.
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Ivory, Spanish, 12C; 1 ft. 2 3/8 in.x 6 19/64 in.x 1 3/8 in.; carved whalebone
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Giotto di Bondone; 1 ft. 5 3/4 in. x 1 ft. 5 1/4 in.; one of a series of six panels, tempera and gold leaf on panel
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Geertgen tot Sint Jans; 3 ft. 1/16 in.x 2 ft. 4 17/64 in.; oil on panel
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Jan Mostaert; 1 ft. 8 5/64 in.x 1 ft. 2 3/8 in.; oil on panel
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8 13/16 in.x 6 3/8 in.x 53/64 in.; elephang ivory
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Mode of access: Internet.
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Mode of access: Internet.
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auctore Carolo Friederico Romano
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Beginning in 1974, the State of Maryland created spatial databases under the MAGI (Maryland's Automated Geographic Information) system. Since that early GIS, other state and local agencies have begun GISs covering a range of applications from critical lands inventories to cadastral mapping. In 1992, state agencies, local agencies, universities, and businesses began a series of GIS coordination activities, resulting in the formation of the Maryland Local Geographic Information Committee and the Maryland State Government Geographic Information Coordinating Committee. GIS activities and system installations can be found in 22 counties plus Baltimore City, and most state agencies. Maryland's decision makers rely on a variety of GIS reports and products to conduct business and to communicate complex issues more effectively. This paper presents the status of Maryland's GIS applications for local and state decision making.
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Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated approximately 2,000, approximately 3,700 and approximately 9,500 SNPs explained approximately 21%, approximately 24% and approximately 29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
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Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases. We report here a genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals. We identified seven loci, including five new loci, associated with mean LTL (P < 5 x 10(-8)). Five of the loci contain candidate genes (TERC, TERT, NAF1, OBFC1 and RTEL1) that are known to be involved in telomere biology. Lead SNPs at two loci (TERC and TERT) associate with several cancers and other diseases, including idiopathic pulmonary fibrosis. Moreover, a genetic risk score analysis combining lead variants at all 7 loci in 22,233 coronary artery disease cases and 64,762 controls showed an association of the alleles associated with shorter LTL with increased risk of coronary artery disease (21% (95% confidence interval, 5-35%) per standard deviation in LTL, P = 0.014). Our findings support a causal role of telomere-length variation in some age-related diseases.